Patents by Inventor Neal L. First

Neal L. First has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Culture of totipotent embryonic inner cells mass cells and production of bovine animals
    Patent number: 6107543
    Abstract: The use of totipotent embryonic stem cells to provide substantially identical cells for embryo cloning techniques is described. The method includes the culture of loose suspensions of inner cell mass cells of bovine animals to retrieve large populations of stem cells. The invention also describes the use of stem cells in various genetic manipulation techniques.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: August 22, 2000
    Assignee: Infigen, Inc.
    Inventors: Michelle M. Sims, Neal L. First
  • In vitro culture of bovine embryos
    Patent number: 5213979
    Abstract: The disclosure herein describes a bovine embryo culture medium which includes epithelial cells from the oviduct of a donor animal. Additionally, a process for maturing immature bovine oocytes in an in vitro bovine culture medium containing epithelial cells from a donor oviduct is described. As an alternative to co-culture of the embryos with the epithelial cells, it is described how a culture medium can be conditioned for the culture of bovine embryos by the culture of epithelial cells therein which are later removed.
    Type: Grant
    Filed: December 30, 1987
    Date of Patent: May 25, 1993
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Neal L. First, Willard Eyestone
  • Multiplying bovine embryos
    Patent number: 4994384
    Abstract: A method of multiplying bovine embryos by transfer of nuclei is described. The method includes enucleating a recipient oocyte, transferring the donor embryo nucleus to the enucleated recipient oocyte, and fusing the donor nucleus to the recipient oocyte by dielectrophoresis. The method is intended to allow the generation of multiplied genetically identical cattle.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: February 19, 1991
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Randall S. Prather, Frank Barnes, James Robl, Neal L. First, Vincent F. Simmon