Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: An automated vehicle jack includes an upper plate and a lower plate with a lifting mechanism disposed therebetween. The upper plate is fixedly attached to a lower side of the vehicle chassis, near each of the front and rear tires. The lifting mechanism is a scissor jack formed of a pair of upper arms pivotally connected to the upper plate and a pair of lower arms pivotally coupled with the lower plate. A motorized drive screw operates the lifting mechanism upon receipt of a predetermined command from a control panel in the vehicle passenger compartment or a portable electronic device.

Abstract: A device and method for baiting a hook with bait, such as a worm. The device is a band engageable body with a rod extending from one end. The distal end of the rod has a hook engaging notch and the other end of the body has a leader engaging notch. In use, a hook is placed in the rod notch, and tension is applied to the leader to secure the hook in place and the leader is placed in said leader engaging notch to maintain such tension. Bait is then forced over the entire hook to generally encapsulate the same. Tension on the leader is released and the encapsulated hook is removed from the hook notch.

Abstract: An exhaust diverter nozzle used in seawater cooling of the exhaust of marine engines, particularly diesel, without added back pressure the nozzle diverts the seawater in the exhaust at low engine rpm (1600-2000 rpm) in a manner which greatly enhances the vaporization of the water producing an evaporative cooling which extends the life of the exhaust tubes.

Abstract: An exhaust diverter nozzle used in seawater cooling of the exhaust of marine engines, particularly diesel, without added back pressure the nozzle diverts the seawater in the exhaust at low engine rpm (1600–2000 rpm) in a manner which greatly enhances the vaporization of the water producing an evaporative cooling which extends the life of the exhaust tubes.

Abstract: This invention is directed to a staged process for producing liquids from coal or similar carbonaceous feeds combining a pretreatment stage and a liquefaction stage. In the process, the feed is dispersed in an organic solvent and reacted with carbon monoxide at an elevated temperature and pressure. The so pretreated coal is sent to a liquefaction reactor, wherein the coal is reacted in the presence of hydrogen and catalyst to produce valuable liquid fuels or feedstocks.