Patents by Inventor Neal R. Pellis

Neal R. Pellis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mineralized three-dimensional bone constructs
    Patent number: 8557576
    Abstract: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: October 15, 2013
    Assignees: The United States of America as represented by the National Aeronautics and Space Administration, University of Houston, Universities Space Research Association
    Inventors: Mark S. F. Clarke, Alamelu Sundaresan, Neal R. Pellis
  • Mineralized Three-Dimensional Bone Constructs
    Publication number: 20120058557
    Abstract: The present disclosure provides ex-vivo derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
    Type: Application
    Filed: November 11, 2011
    Publication date: March 8, 2012
    Inventors: Mark S.F. Clarke, Alamelu Sundaresan, Neal R. Pellis
  • Mineralized three-dimensional bone constructs
    Patent number: 8076136
    Abstract: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: December 13, 2011
    Assignees: The United States of America as represented by the United States National Aeronautics and Space Administration, University of Houston, Universities Space Research Association
    Inventors: Mark S. F. Clarke, Alamelu Sundaresan, Neal R. Pellis
  • MINERALIZED THREE-DIMENSIONAL BONE CONSTRUCTS
    Publication number: 20100227358
    Abstract: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
    Type: Application
    Filed: May 17, 2010
    Publication date: September 9, 2010
    Applicant: OSTEOSPHERE, LLC
    Inventors: Mark S.F. Clarke, Alamelu Sundaresan, Neal R. Pellis
  • MINERALIZED THREE-DIMENSIONAL BONE CONSTRUCTS
    Publication number: 20090061479
    Abstract: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
    Type: Application
    Filed: March 29, 2007
    Publication date: March 5, 2009
    Inventors: Mark S.F. Clarke, Alamelu Sundaresan, Neal R. Pellis