Abstract: Methods and systems are provided for generating and utilizing a genetically engineered bacterium comprising a modification in glnD, wherein said modification is selected from the group consisting of: deletion of the entire gene, deletion of substantially the entire gene, deletion of an ACT domain, deletion of more than 50% of an ACT domain, deactivation of an ACT domain, and deactivation of an UTase domain.

Abstract: A computing system locating system includes a computing system having a computing system light emitting device that is configured to emit light to provide a computing system locating signal, and a vibration-based location indication system. The vibration-based location indication system includes a light detection subsystem that is configured to detect the computing system locating signal via the light emitted from the computing system light emitting device on the computing system, and a vibration subsystem that is configured to vibrate. A location indication subsystem in the vibration-based location indication system that is coupled to the light detection subsystem and the vibration subsystem determines that the light detection subsystem has detected the computing system locating signal via the light emitted from the computing system light emitting device on the computing system and, in response, drives the vibration subsystem to produce a vibration to indicate the location of the computing system.

Abstract: A vibration-based location indication system includes a computing system that is coupled to a management system via a network. The computing system includes a computing system vibration device, and a computing system location indication subsystem that is coupled to the network and the computing system vibration device. The computing system location indication subsystem receives a computing system location indication instruction to indicate a location of the computing system from the management system via the network and, based on the computing system location indication instruction, drives the computing system vibration device to produce a vibration that is configured to indicate the location of the computing system.

Abstract: This disclosure is directed to methods of treating or inhibiting mitochondrial dysfunction or mitochondrial disease in a subject comprising administration of and effective amount of one or more of (+) Epicatechin (?) epicatechin, 11-hydroxyprogesterone, and 11-?-hydroxypregnenolone and other efficacious agents in a pharmaceutically acceptable carrier. Agents can be administered alone or in certain synergistic combinations. The compositions and methods described effectively reduce or alleviate primary respiratory chain dysfunction symptoms, and have efficacy for improving cellular resiliency, stress resistance, and symptoms associated with primary, secondary, or acute respiratory chain dysfunction.

Abstract: Methods and systems are provided for generating and utilizing a genetically engineered bacterium comprising a modification in glnD, wherein said modification is selected from the group consisting of: deletion of the entire gene, deletion of substantially the entire gene, deletion of an ACT domain, deletion of more than 50% of an ACT domain, deactivation of an ACT domain, and deactivation of an UTase domain.

Abstract: A system comprising a first expired drug usability device is provided. The first expired drug usability device comprises a first spectrometer and one or more first processors. The first processors are configured to: obtain at least one expired drug machine learning-artificial intelligence (ML-AI) model associated with a pharmaceutical drug; obtain drug expiration information of a sample of the pharmaceutical drug, wherein the drug expiration information comprises spectrometer data associated with using the first spectrometer on the sample; input the drug expiration information into the at least one expired drug ML-AI model to determine usability information associated with the sample of the pharmaceutical drug; and perform one or more actions based on the usability information.

Abstract: Methods and systems are provided for generating and utilizing a genetically engineered bacterium comprising a modification in a gene regulating nitrogen fixation or assimilation, wherein the modification in the gene regulating nitrogen fixation or assimilation results in one or more of: constitutive expression of a nifA gene in nitrogen limiting and non-nitrogen limiting conditions, activity of nifA in non-nitrogen limiting conditions, decreased uridylyl-transferase activity of GlnD, decreased adenylyl-removing activity of GlnE, and increased ammonium excretion.

Abstract: The present disclosure provides consortia of microbes that are functionally optimized for nitrogen fixation and deliver such to plants in a targeted, efficient, and environmentally sustainable manner. The microbes within the consortium differ in nutrient utilization, temporal occupation, oxygen adaptability, and/or spatial occupation, which enables the microbes to deliver nitrogen to a cereal plant in a spatially targeted (e.g. rhizospheric) and temporally targeted (e.g. during advantageous stages of plant's life cycle) manner. The present disclosure also provides methods of creating a synthetic composition of microbes and methods of using compositions of microbes to fix atmospheric nitrogen and deliver such to a crop.

Abstract: A genetically engineered bacterium with a modification in one or more genes selected from: NAC, ptsH, iaaA, gltA, pga, sdiA, fimA1, fimA2, fimA3, fimA4, wzxE, bolA, iscR, fhuF, sodA, sodB, sodC, FNR, arcA, arcB, rpoS, sbnA, treA, treB, phoP, phoQ, yjjPB, ychM, dauA, actP, yusV1, yieL1, yieL2, yieL3, yieL4, pgaB, rafA, melA, uidA, manA, abfA, abnA, lacZ, and yusV2 is disclosed. Methods of use of the genetically engineered bacterium to provide fixed nitrogen to plants, and compositions including the bacterium are also provided.

Abstract: Methods of predicting in planta phenotypes of microbial strains are provided. The methods can include culturing microbial strains in a plant exudate medium and assaying in vitro phenotypes of the microbial strains. The methods may also include using the in vitro phenotypes to predict in planta phenotypes of the microbial strains. Methods of using the microbial strains in field trials are also provided.

Abstract: A stage apparatus is disclosed for supporting and positioning a body tissue sample in a microscope. The stage apparatus has (a) an elongated base mount having a longitudinal body extending between a first end and a second end, (b) means for attaching the first end of the base to a mount or platform associated with the microscope, (c) a tissue mount having a tissue well attached to an elongated mount stem, the tissue well of sufficient size and shape to store the body tissue sample, and (d) means for attaching the second end of the base mount and the tissue mount, the tissue mount being removable and separable from the base mount.

Abstract: Methods and systems are provided for generating and utilizing a genetically engineered bacterium comprising a modification in glnD, wherein said modification is selected from the group consisting of: deletion of the entire gene, deletion of substantially the entire gene, deletion of an ACT domain, deletion of more than 50% of an ACT domain, deactivation of an ACT domain, and deactivation of an UTase domain.

Abstract: The present application concerns automated optimization, customization or production methods for the design of a solar photovoltaic array, involving one or more or all components in a photovoltaic array, in which the products include system designs, production drawings, permitting and construction drawings, layouts for the mechanical and electrical systems, bill of materials and financial return analyses of such a photovoltaic array.

Abstract: A stage apparatus is disclosed for supporting and positioning a body tissue sample in a microscope. The stage apparatus has (a) an elongated base mount having a longitudinal body extending between a first end and a second end, (b) means for attaching the first end of the base to a mount or platform associated with the microscope, (c) a tissue mount having a tissue well attached to an elongated mount stem, the tissue well of sufficient size and shape to store the body tissue sample, and (d) means for attaching the second end of the base mount and the tissue mount, the tissue mount being removable and separable from the base mount.

Abstract: The present application concerns automated optimization, customization or production methods for the design of a solar photovoltaic array, involving one or more or all components in a photovoltaic array, in which the products include system designs, production drawings, permitting and construction drawings, layouts for the mechanical and electrical systems, bill of materials and financial return analyses of such a photovoltaic array.