Patents by Inventor Nebojsa Avdalovic
Nebojsa Avdalovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210389289Abstract: Systems and methods for inhibiting translocation of ions across ion exchange barriers include an eluent generator having an ion source reservoir with a first electrode, an eluent generation chamber with a second electrode, an ion exchange barrier disposed therebetween, and means for reversing the polarity of a voltage or current applied across the first and second electrodes. A first polarity voltage or current applied across the electrodes generates an electric field that promotes translocation of eluent counter ions from the reservoir across the barrier, where the counter ions combine with eluent ions electrolytically generated in the chamber. By reversing the polarity of the voltage or current across the electrodes, the resulting electric field inhibits translocation of counter ions across the barrier from the reservoir into the chamber. Reverse voltage or current bias reduces counter ion concentration in the resting chamber to prevent exhaustion of ion suppressor capacity during start up.Type: ApplicationFiled: August 27, 2021Publication date: December 16, 2021Inventors: Kannan Srinivasan, Mrinal Sengupta, Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic
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Patent number: 11105782Abstract: Systems and methods for inhibiting translocation of ions across ion exchange barriers include an eluent generator having an ion source reservoir with a first electrode, an eluent generation chamber with a second electrode, an ion exchange barrier disposed therebetween, and means for reversing the polarity of a voltage or current applied across the first and second electrodes. A first polarity voltage or current applied across the electrodes generates an electric field that promotes translocation of eluent counter ions from the reservoir across the barrier, where the counter ions combine with eluent ions electrolytically generated in the chamber. By reversing the polarity of the voltage or current across the electrodes, the resulting electric field inhibits translocation of counter ions across the barrier from the reservoir into the chamber. Reverse voltage or current bias reduces counter ion concentration in the resting chamber to prevent exhaustion of ion suppressor capacity during start up.Type: GrantFiled: October 10, 2017Date of Patent: August 31, 2021Assignee: Dionex CorporationInventors: Kannan Srinivasan, Mrinal Sengupta, Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic
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Publication number: 20190107518Abstract: Systems and methods for inhibiting translocation of ions across ion exchange barriers include an eluent generator having an ion source reservoir with a first electrode, an eluent generation chamber with a second electrode, an ion exchange barrier disposed therebetween, and means for reversing the polarity of a voltage or current applied across the first and second electrodes. A first polarity voltage or current applied across the electrodes generates an electric field that promotes translocation of eluent counter ions from the reservoir across the barrier, where the counter ions combine with eluent ions electrolytically generated in the chamber. By reversing the polarity of the voltage or current across the electrodes, the resulting electric field inhibits translocation of counter ions across the barrier from the reservoir into the chamber. Reverse voltage or current bias reduces counter ion concentration in the resting chamber to prevent exhaustion of ion suppressor capacity during start up.Type: ApplicationFiled: October 10, 2017Publication date: April 11, 2019Inventors: Kannan SRINIVASAN, Mrinal SENGUPTA, Yan LIU, Christopher A. POHL, Nebojsa AVDALOVIC
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Patent number: 9645124Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.Type: GrantFiled: January 10, 2013Date of Patent: May 9, 2017Assignee: DIONEX CORPORATIONInventors: Yan Liu, Hamish Small, Nebojsa Avdalovic
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Patent number: 9283495Abstract: An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.Type: GrantFiled: March 6, 2013Date of Patent: March 15, 2016Assignee: DIONEX CORPORATIONInventors: Yan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
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Patent number: 8784655Abstract: A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.Type: GrantFiled: September 22, 2011Date of Patent: July 22, 2014Assignee: Dionex CorporationInventors: Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic, John M. Riviello, Archava Siriraks
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Patent number: 8647576Abstract: An acid or base is generated in an aqueous solution by the steps of: (a) providing a source of first ions adjacent an aqueous liquid in a first acid or base generation zone, separated by a first barrier (e.g., anion exchange membrane) substantially preventing liquid flow and transporting ions only of the same charge as said first ions, (b) providing a source of second ions of opposite charge adjacent an aqueous liquid in a second acid or base generation zone, separated by a second barrier transporting ions only of the same charge as the second ions, and (c) transporting ions across the first barrier by applying an electrical potential through said first and second zones to generate an acid-containing aqueous solution in one of said first or second zones and a base-containing aqueous solution in the other one which may be combined to form a salt. Also, electrolytic apparatus for performing the above method.Type: GrantFiled: June 15, 2010Date of Patent: February 11, 2014Assignee: Dionex CorporationInventors: Yan Liu, Nebojsa Avdalovic
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Publication number: 20140004001Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.Type: ApplicationFiled: January 10, 2013Publication date: January 2, 2014Inventors: Yan LIU, Hamish SMALL, Nebojsa AVDALOVIC
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Publication number: 20130180922Abstract: An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Inventors: Yan LIU, Victor Manuel Berber BARRETO, Christopher A. POHL, Nebojsa AVDALOVIC
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Patent number: 8425778Abstract: The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.Type: GrantFiled: May 4, 2012Date of Patent: April 23, 2013Assignee: Dionex CorporationInventors: Xiadong Liu, Christopher A. Pohl, Andrei V. Bordunov, Nebojsa Avdalovic
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Patent number: 8415168Abstract: An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.Type: GrantFiled: May 23, 2012Date of Patent: April 9, 2013Assignee: Dionex CorporationInventors: Yan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
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Patent number: 8367423Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.Type: GrantFiled: February 17, 2010Date of Patent: February 5, 2013Assignee: Dionex CorporationInventors: Yan Liu, Hamish Small, Nebojsa Avdalovic
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Publication number: 20130026099Abstract: The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.Type: ApplicationFiled: May 4, 2012Publication date: January 31, 2013Applicant: Dionex CorporationInventors: Xiadong Liu, Christopher A. Pohl, Andrei V. Bordunov, Nebojsa Avdalovic
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Patent number: 8308952Abstract: A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.Type: GrantFiled: May 25, 2012Date of Patent: November 13, 2012Assignee: Dionex CorporationInventors: Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic, John M. Riviello, Arachava Siriraks
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Publication number: 20120255910Abstract: A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.Type: ApplicationFiled: May 25, 2012Publication date: October 11, 2012Applicant: DIONEX CORPORATIONInventors: Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic, John M. Riviello, Archava Siriraks
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Publication number: 20120228227Abstract: An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.Type: ApplicationFiled: May 23, 2012Publication date: September 13, 2012Applicant: DIONEX CORPORATIONInventors: Yan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
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Patent number: 8216515Abstract: An apparatus for capillary ion chromatography having a suppressor having flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.Type: GrantFiled: September 16, 2004Date of Patent: July 10, 2012Assignee: Dionex CorporationInventors: Yan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
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Patent number: 8182679Abstract: The present invention, provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.Type: GrantFiled: April 28, 2008Date of Patent: May 22, 2012Assignee: Dionex CorporationInventors: Xiaodong Liu, Christopher A. Pohl, Andrei V. Bordunov, Nebojsa Avdalovic
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Publication number: 20120024793Abstract: A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.Type: ApplicationFiled: September 22, 2011Publication date: February 2, 2012Applicant: Dionex CorporationInventors: Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic, John M. Riviello, Archava Siriraks
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Patent number: 8043507Abstract: A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.Type: GrantFiled: December 12, 2007Date of Patent: October 25, 2011Assignee: Dionex CorporationInventors: Yan Liu, Christopher A. Pohl, Nebojsa Avdalovic, John M. Riviello, Archava Siriraks