Patents by Inventor Ned D. Reimer

Ned D. Reimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3? end tagged oligonucleotides
    Patent number: 7582436
    Abstract: The present invention provides compositions comprising oligonucleotides that have 3? end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3? end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: September 1, 2009
    Assignee: Third Wave Technologies, Inc.
    Inventors: Jeff G. Hall, Zbigniev Skrzypczynski, Sarah Wayland, Ned D. Reimer, Luis P. Reynaldo, Joerg Baier, Victor Lyamichev, Bruce P. Neri
  • 3' end tagged oligonucleotides
    Publication number: 20080293930
    Abstract: The present invention provides compositions comprising oligonucleotides that have 3? end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3? end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.
    Type: Application
    Filed: April 18, 2007
    Publication date: November 27, 2008
    Inventors: Jeff G. Hall, Zbigniev Skrzypczynski, Sarah Wayland, Ned D. Reimer, Luis P. Reynaldo, Joerg Baier, Victor Lyamichev, Bruce P. Neri
  • Nucleic acid synthesizers
    Patent number: 6932943
    Abstract: The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis, as well as methods of modifying pre-existing synthesizers to improve efficiency, reliability, and safety.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: August 23, 2005
    Assignee: Third Wave Technologies
    Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer, Rocky Ganske
  • 3' end tagged oligonucleotides
    Publication number: 20040161749
    Abstract: The present invention provides compositions comprising oligonucleotides that have 3′ end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3′ end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.
    Type: Application
    Filed: January 24, 2003
    Publication date: August 19, 2004
    Inventors: Jeff G. Hall, Zbigniev Skrzypczynski, Sarah Wayland, Ned D. Reimer, Luis P. Reynaldo, Joerg Baier, Victor Lyamichev, Bruce P. Neri
  • Polymer synthesizer
    Publication number: 20030124526
    Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.
    Type: Application
    Filed: August 15, 2001
    Publication date: July 3, 2003
    Applicant: Third Wave Technologies, Inc.
    Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
  • Polymer synthesizer
    Publication number: 20030113237
    Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.
    Type: Application
    Filed: August 15, 2001
    Publication date: June 19, 2003
    Applicant: Third Wave Technologies, Inc.
    Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
  • Polymer synthesizer
    Publication number: 20030113236
    Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.
    Type: Application
    Filed: August 15, 2001
    Publication date: June 19, 2003
    Applicant: Third Wave Technologies, Inc.
    Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
  • Polymer synthesizer
    Publication number: 20030072689
    Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.
    Type: Application
    Filed: August 15, 2001
    Publication date: April 17, 2003
    Applicant: Third Wave Technologies, Inc.
    Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
  • Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
    Patent number: 5986086
    Abstract: A chemical compound of the following formula: ##STR1## wherein R.sup.1 is selected from the group consisting of alkyl, aralkyl, and substituted alkyl groups; R.sup.3 is selected from the group consisting of H, PO.sub.3.sup.-2, P.sub.2 O.sub.6.sup.-3 ; P.sub.3 O.sub.9.sup.-4, and .alpha.-thio phoshates (PSO.sub.2.sup.-2 ; P.sub.2 SO.sub.5.sup.-3 ; P.sub.3 O.sub.8.sup.-4); and .alpha.BH.sub.3.sup.- phosphates (P(BH.sub.3)O.sub.2.sup.-2, P.sub.2 (BH.sub.3)O.sub.5.sup.-3, P.sub.3 (BH.sub.3)O.sub.8.sup.-4); R.sup.4 is selected from the group consisting of H, lower alkyl, acyl, (CH.sub.2).sub.p COO(CH.sub.2).sub.q CH.sub.3 wherein p is an integer from 0 to 4 and q is an integer from 0 to 4, and 5,6; 6,7; or 7,8-butadienyl; R.sup.5 is selected from the group consisting of H lower alkyl, acyl, (CH.sub.2).sub.p COO(CH.sub.2).sub.q CH.sub.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: November 16, 1999
    Assignee: Amersham Pharmacia Biotech Inc.
    Inventors: Charles K. Brush, Ned D. Reimer