Patents by Inventor Ned Porter

Ned Porter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 10675285
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: June 9, 2020
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9545385
    Abstract: Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: January 17, 2017
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Pharmaceutical composition comprising bicyclic pyridinol derivatives for preventing or treating diseases caused by angiogenesis
    Patent number: 9505757
    Abstract: Disclosed is a pharmaceutical composition including a bicyclic pyridinol derivative as an active ingredient for preventing or treating diseases caused by angiogenesis. The bicyclic pyridinol derivative expressed by Chemical Formula 1 can be effectively used as a drug for preventing and treating diseases caused by angiogenesis since it inhibits neovascularization in a chorioallantoic membrane model.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: November 29, 2016
    Assignee: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY
    Inventors: Byeong Seon Jeong, Jung Ae Kim, You Ra Kang, Tae Gyu Nam, Jin Mo Ku, Ned A. Porter
  • Inhibitors of Hemeprotein-Catalyzed Lipid Peroxidation
    Publication number: 20160067256
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 10, 2016
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
    Publication number: 20150368241
    Abstract: Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
    Type: Application
    Filed: February 5, 2014
    Publication date: December 24, 2015
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter
  • PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC PYRIDINOL DERIVATIVES FOR PREVENTING OR TREATING DISEASES CAUSED BY ANGIOGENESIS
    Publication number: 20150320729
    Abstract: Disclosed is a pharmaceutical composition including a bicyclic pyridinol derivative as an active ingredient for preventing or treating diseases caused by angiogenesis. The bicyclic pyridinol derivative expressed by Chemical Formula 1 can be effectively used as a drug for preventing and treating diseases caused by angiogenesis since it inhibits neovascularization in a chorioallantoic membrane model.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 12, 2015
    Inventors: Byeong Seon JEONG, Jung Ae KIM, You Ra KANG, Tae Gyu NAM, Jin Mo KU, Ned A. PORTER
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9133212
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 15, 2015
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC PYRIDINOL DERIVATIVES FOR PREVENTING OR TREATING DISEASES CAUSED BY ANGIOGENESIS
    Publication number: 20150031890
    Abstract: There is provided a pharmaceutical composition comprising a bicyclic pyridinol derivative as an active ingredient for preventing or treating diseases caused by angiogenesis. The bicyclic pyridinol derivative expressed by Chemical Formula 1 can be effectively used as a drug for preventing and treating diseases caused by angiogenesis since it inhibits neovascularization in a chorioallantoic membrane model.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 29, 2015
    Inventors: Byeong Seon Jeong, Jung Ae Kim, You Ra Kang, Tae Gyu Nam, Jin Mo Ku, Ned A. Porter
  • Cleavable surfactants and methods of use thereof
    Patent number: 8697447
    Abstract: The present invention includes a cleavable surfactant/detergent compound of the following formula: wherein the variables are defined herein. Embodiments of the cleavable surfactant/detergent compound are useful, for example, in methods for isolating a hydrophobic molecule that include providing a plasma comprising a hydrophobic molecule, applying the cleavable surfactant to the plasma so that the surfactant engages the hydrophobic molecule, cleaving the surfactant from the hydrophobic molecule, and analyzing said hydrophobic molecule.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: April 15, 2014
    Assignee: Vanderbilt University
    Inventors: Richard M Caprioli, Ned A. Porter, Jeremy L. Norris
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 8367669
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: February 5, 2013
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, II, Ned A. Porter, Olivier Boutaud
  • CLEAVABLE SURFACTANTS AND METHODS OF USE THEREOF
    Publication number: 20110217783
    Abstract: Cleavable compositions that comprise a polar head, cleavable linker, and a hydrophobic tail; and methods for using them to isolate hydrophobic molecules.
    Type: Application
    Filed: November 15, 2010
    Publication date: September 8, 2011
    Inventors: Richard M. Caprioli, Ned A. Porter, Jeremy L. Norris
  • MS based peptide and protein sequencing via reactions of lysine residues with peroxycarbonate compounds
    Patent number: 7858388
    Abstract: A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: December 28, 2010
    Assignee: Vanderbilt University
    Inventors: Ned A. Porter, Douglas S. Masterson, Huiyong Yin, Richard M. Caprioli, Jeremy L. Norris
  • INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
    Publication number: 20080227776
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Application
    Filed: March 26, 2008
    Publication date: September 18, 2008
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • MOLECULAR DETECTION BY MATRIX FREE DESORPTION IONIZATION MASS SPECTROMETRY
    Publication number: 20080113875
    Abstract: The present invention provides methods for obtaining information of a plurality of target molecules by matrix free LDI MS. Mass tagged complexes for detection of target molecules comprise a target molecule binding domain, and a mass tag separated by a cleavable linker. Methods of the invention may be used for example to analyze the distribution of a multiple target molecules in a complex sample, such as a tissue section.
    Type: Application
    Filed: September 7, 2007
    Publication date: May 15, 2008
    Inventors: Pierre Chaurand, Jeremy L. Norris, Ned A. Porter, Junhai Yang, Richard M. Caprioli
  • Peptide and Protein Fragmentation by Lysine Residue Originated Reactions
    Publication number: 20070249056
    Abstract: A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.
    Type: Application
    Filed: October 14, 2004
    Publication date: October 25, 2007
    Inventors: Ned Porter, Douglas Masterson, Huiyong Yin, Richard Caprioli, Jeremy Norris
  • CLEAVABLE SURFACTANTS AND METHODS OF USE THEREOF
    Publication number: 20060240562
    Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
    Type: Application
    Filed: July 6, 2006
    Publication date: October 26, 2006
    Inventors: Richard Caprioli, Ned Porter, Jeremy Norris
  • Cleavable surfactants and methods of use thereof
    Patent number: 7074936
    Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: July 11, 2006
    Assignee: Vanderbilt University
    Inventors: Richard M. Caprioli, Ned A. Porter, Jeremy L. Norris
  • Cleavable surfactants and methods of use thereof
    Publication number: 20040152913
    Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
    Type: Application
    Filed: December 1, 2003
    Publication date: August 5, 2004
    Inventors: Richard M Caprioli, Ned A Porter, Jeremy L Norris
  • Light activated acyl-enzymes
    Patent number: 5218137
    Abstract: Light activated acyl-enzymes of the formula: ##STR1## are disclosed. In the compounds of Formula (III), ENZ is an enzyme, X is O or S, Y is --NR.sub.3 R.sub.4, --OR.sub.5, or --SR.sub.5, and Z is a nucleophile. m is 0 to 3 and n is 1 or 2. Y is substituted on the ring at either or both of the 4 and 6 position.R.sub.1 and R.sub.2 are each independently H, C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl.R.sub.3 and R.sub.4 are each independently H, C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl, except that R.sub.3 and R.sub.4 are not simultaneously both H. R.sub.5 is C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl.Methods of using the acyl-enzymes and intermediates for making the acyl-enzymes are disclosed.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: June 8, 1993
    Assignee: Duke University
    Inventors: Ned A. Porter, John D. Bruhnke
  • Light activated acyl-enzymes
    Patent number: 5114851
    Abstract: Light activated acyl-enzymes of the formula: ##STR1## are disclosed. In the compounds of Formula (III), ENZ is an enzyme, X is O or S, Y is --NR.sub.3 R.sub.4, --OR.sub.5, or --SR.sub.5, and Z is a nucleophile. m is 0 to 3 and n is 1 or 2. Y is substituted on the ring at either or both of the 4 and 6 position.R.sub.1 and R.sub.2 are each independently H, C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl.R.sub.3 and R.sub.4 are each independently H, C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl, except that R.sub.3 and R.sub.4 are not simultaneously both H. R.sub.5 is C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl.Methods of using the acyl-enzymes and intermediates for making the acyl-enzymes are disclosed.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: May 19, 1992
    Assignee: Duke University
    Inventors: Ned A. Porter, John D. Bruhnke