Abstract: Systems and methods for analyzing micro-ribonucleic acid (miRNA) signature profiles in a biological sample to identify profiles of a subject to biotic and abiotic agents are disclosed. A system comprises an extractor unit and a nucleic acid amplifying unit that communicate with one or more hardware processors. Extracted miRNA concentrations using extractor unit are amplified by nucleic acid amplifying unit, using a plurality of primers, and statistical modeling-based techniques. The one or more hardware processors analyze miRNA profiling data using statistical modeling-based techniques to identify a plurality of miRNA signature sequences and profiles indicative of exposure to various biotic and abiotic agents. The processors compare sequences and profiles with pre-defined miRNA signature sequences and profiles in a database and on a display, indicating the subject's response to each biotic or abiotic agent.

Abstract: Provided is an analytical device including: a self-flowing microfluidic system, having a sample extraction location, at least one sample preparation location, and at least one sample analytical chamber; wherein the sample extraction location, the sample preparation location, and the at least one sample analytical chamber are interconnected by at least one microfluidic channel on a first substrate; and a signal readout system, having at least one sample analysis elements, and a data gathering and processing element.

Abstract: A spatially selective surface functionalization device configured to generate a pattern of micro plasmas and functionalize a substrate surface may include: a pattern management system, a patterning head, and a gas delivery system, wherein the gas delivery system provides a primed gas mixture for forming a plasma between the patterning head and a target substrate below the patterning head. A patterning head may generate a distribution of micro plasmas from individual directed beams of electrons with spatial separation. A pattern management system may store and manipulate information about a pattern of surface functionalization and generate instructions for regulating a distribution of micro plasmas that functionalize a substrate surface.

Abstract: A self-flowing microfluidic analytical chip may undergo spontaneous flow of a fluidic sample through microfluidic channels without an internal or external pump or corresponding pumping support hardware for fluid pumping. A self-flowing microfluidic analytical device includes sample preparation locations, sample analysis locations, and sample extraction locations connected by a network of microfluidic channels. Self-flowing characteristics of a microfluidic analytical chip result from maskless patterning of a substrate surface, where sequential passes of a patterning head preserve, rather than destroy, a pattern of surface functionalization. Self-flowing properties may be preserved by avoiding use of mask-removing solvents common to mask-removal steps in traditional microfluidic chip manufacturing processes.

Abstract: A self-flowing microfluidic analytical chip may undergo spontaneous flow of a fluidic sample through microfluidic channels without an internal or external pump or corresponding pumping support hardware for fluid pumping. A self-flowing microfluidic analytical device includes sample preparation locations, sample analysis locations, and sample extraction locations connected by a network of microfluidic channels. Self-flowing characteristics of a microfluidic analytical chip result from maskless patterning of a substrate surface, where sequential passes of a patterning head preserve, rather than destroy, a pattern of surface functionalization. Self-flowing properties may be preserved by avoiding use of mask-removing solvents common to mask-removal steps in traditional microfluidic chip manufacturing processes.

Abstract: Provided is an analytical device including: a self-flowing microfluidic system, having a sample extraction location, at least one sample preparation location, and at least one sample analytical chamber; wherein the sample extraction location, the sample preparation location, and the at least one sample analytical chamber are interconnected by at least one microfluidic channel on a first substrate; and a signal readout system, having at least one sample analysis elements, and a data gathering and processing element.

Abstract: A spatially selective surface functionalization device configured to generate a pattern of micro plasmas and functionalize a substrate surface may include: a pattern management system, a patterning head, and a gas delivery system, wherein the gas delivery system provides a primed gas mixture for forming a plasma between the patterning head and a target substrate below the patterning head. A patterning head may generate a distribution of micro plasmas from individual directed beams of electrons with spatial separation. A pattern management system may store and manipulate information about a pattern of surface functionalization and generate instructions for regulating a distribution of micro plasmas that functionalize a substrate surface.

Abstract: A spatially selective surface functionalization device configured to generate a pattern of micro plasmas and functionalize a substrate surface may include: a pattern management system, a patterning head, and a gas delivery system, wherein the gas delivery system provides a primed gas mixture for forming a plasma between the patterning head and a target substrate below the patterning head. A patterning head may generate a distribution of micro plasmas from individual directed beams of electrons with spatial separation. A pattern management system may store and manipulate information about a pattern of surface functionalization and generate instructions for regulating a distribution of micro plasmas that functionalize a substrate surface.

Abstract: Provided is an analytical device including: a self-flowing microfluidic system, having a sample extraction location, at least one sample preparation location, and at least one sample analytical chamber; wherein the sample extraction location, the sample preparation location, and the at least one sample analytical chamber are interconnected by at least one microfluidic channel on a first substrate; and a signal readout system, having at least one sample analysis elements, and a data gathering and processing element.

Abstract: An electron-beam induced plasma is utilized to establish a non-mechanical, electrical contact to a device of interest. This plasma source may be referred to as atmospheric plasma source and may be configured to provide a plasma column of very fine diameter and controllable characteristics. The plasma column traverses the atmospheric space between the plasma source into the atmosphere and the device of interest and acts as an electrical path to the device of interest in such a way that a characteristic electrical signal can be collected from the device. Additionally, by controlling the gases flowing into the plasma column the probe may be used for surface modification, etching and deposition.

Abstract: An electron-beam induced plasmas is utilized to establish a non-mechanical, electrical contact to a device of interest. This plasma source may be referred to as atmospheric plasma source and may be configured to provide a plasma column of very fine diameter and controllable characteristics. The plasma column traverses the atmospheric space between the plasma source into the atmosphere and the device of interest and acts as an electrical path to the device of interest in such a way that a characteristic electrical signal can be collected from the device. Additionally, by controlling the gases flowing into the plasma column the probe may be used for surface modification, etching and deposition.

Abstract: Various embodiments include computer-implemented methods, computer program products and systems for generating an integrated circuit (IC) library for use in a scatterometry analysis. In some cases, approaches include: obtaining chip design data about at least one IC chip; obtaining user input data about the at least one IC chip; and running an IC library defining program using the chip design data in its original format and the user input data in its original format, the running of the IC library defining program including: determining a process variation for the at least one IC chip based upon the chip design data and the user input data; converting the process variation into shape variation data; and providing the shape variation data in a text format to a scatterometry modeling program for use in the scatterometry analysis.

Abstract: Various embodiments include computer-implemented methods, computer program products and systems for generating an integrated circuit (IC) library for use in a scatterometry analysis. In some cases, approaches include: obtaining chip design data about at least one IC chip; obtaining user input data about the at least one IC chip; and running an IC library defining program using the chip design data in its original format and the user input data in its original format, the running of the IC library defining program including: determining a process variation for the at least one IC chip based upon the chip design data and the user input data; converting the process variation into shape variation data; and providing the shape variation data in a text format to a scatterometry modeling program for use in the scatterometry analysis.