Abstract: A spinal implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body defines a cavity. A plate is connectable with the implant body via a coupling member adjacent the cavity and is translatable relative thereto. The coupling member has a portion including a frangible torque limit. The plate defines at least one opening oriented to implant a fastener with tissue. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: Provided herein are peptide amphiphiles (PAs). In some embodiments, provided herein are targeting PAs comprising a PA backbone and a targeting moiety. In some embodiments, provided herein are therapeutic PAs comprising a PA backbone and a therapeutic agent. In some embodiments, the peptide amphiphiles are co-assembled into nanofibers. In some embodiments, the nanofibers may be used for the treatment of atherosclerosis or related disease.

Abstract: A spinal implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body defines a cavity. A plate is connectable with the implant body via a coupling member adjacent the cavity and is translatable relative thereto. The coupling member has a portion including a frangible torque limit. The plate defines at least one opening oriented to implant a fastener with tissue. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: The present application discloses methods for treating spinal deformities. One embodiment includes inserting an elongated corrective member into the patient. During insertion, the corrective member is operatively attached to a first vertebral member that applies a first corrective force to correct a first vertebral member alignment. The corrective member is further inserted into the patient and subsequently operatively attached to a second vertebral member that applies a second corrective force to correct a second vertebral member alignment. The corrective member is further inserted and subsequently operatively attached to a third vertebral member that applies a third corrective force to correct a third vertebral member alignment. The embodiment may further include operatively attaching the corrective member to additional vertebral members to correct further misalignment. In one embodiment, a second member is attached to the vertebral members after they have been aligned to maintain the alignment.

Abstract: A spinal implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body defines a cavity. A plate is connectable with the implant body via a coupling member adjacent the cavity and is translatable relative thereto. The coupling member has a portion including a frangible torque limit. The plate defines at least one opening oriented to implant a fastener with tissue. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A spinal implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body defines a cavity. A plate is connectable with the implant body via a coupling member adjacent the cavity and is translatable relative thereto. The coupling member has a portion including a frangible torque limit. The plate defines at least one opening oriented to implant a fastener with tissue. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A method for treating a spine, comprises the steps of fastening a first fastener to a first portion of vertebrae, a second fastener to a second portion of vertebra, and a third fastener to a third portion of vertebrae, wherein the second portion of vertebra is between the first and third vertebra; providing a longitudinal element having a first portion and a second portion; passing the first portion of the longitudinal element through the second and third fasteners such that the second portion of the longitudinal element extends from the second fastener through the third fastener; bending the first portion of the longitudinal element to a selected curvature; and moving the second portion of the longitudinal element through the second fastener to the first fastener after the first portion of the longitudinal element has been passed through the second and third fasteners. Systems and instruments are disclosed.

Abstract: A spinal implant includes an implant body extending between an anterior surface and a posterior surface. The implant body includes a first vertebral engaging surface and a second vertebral engaging surface. The implant body defines a cavity. A plate is connectable with the implant body via a coupling member adjacent the cavity and is translatable relative thereto. The coupling member has a portion including a frangible torque limit. The plate defines at least one opening oriented to implant a fastener with tissue. Systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A method for treating a spine comprises the steps of: fastening a plurality of fasteners with a lateral portion of vertebrae, each of the fasteners including a first element that defines an implant cavity and a second element configured for penetrating the vertebrae; providing a longitudinal element including a portion having a selected curvature; disposing the longitudinal element with the implant cavities such that the portion is disposed in a selected orientation relative to the vertebrae; and moving a first element of at least one of the fasteners relative to the portion such that a second element of the at least one of the fasteners derotates the vertebrae while maintaining the portion in the selected orientation. Systems and implants are disclosed.

Abstract: A method for treating a spine, comprises the steps of fastening a first fastener to a first portion of vertebrae, a second fastener to a second portion of vertebra, and a third fastener to a third portion of vertebrae, wherein the second portion of vertebra is between the first and third vertebra; providing a longitudinal element having a first portion and a second portion; passing the first portion of the longitudinal element through the second and third fasteners such that the second portion of the longitudinal element extends from the second fastener through the third fastener; bending the first portion of the longitudinal element to a selected curvature; and moving the second portion of the longitudinal element through the second fastener to the first fastener after the first portion of the longitudinal element has been passed through the second and third fasteners. Systems and instruments are disclosed.

Abstract: The present application discloses methods for treating spinal deformities. One embodiment includes inserting an elongated corrective member into the patient. During insertion, the corrective member is operatively attached to a first vertebral member that applies a first corrective force to correct a first vertebral member alignment. The corrective member is further inserted into the patient and subsequently operatively attached to a second vertebral member that applies a second corrective force to correct a second vertebral member alignment. The corrective member is further inserted and subsequently operatively attached to a third vertebral member that applies a third corrective force to correct a third vertebral member alignment. The embodiment may further include operatively attaching the corrective member to additional vertebral members to correct further misalignment. In one embodiment, a second member is attached to the vertebral members after they have been aligned to maintain the alignment.

Abstract: A method for treating a spine comprises the steps of: fastening a plurality of fasteners with a lateral portion of vertebrae, each of the fasteners including a first element that defines an implant cavity and a second element configured for penetrating the vertebrae; providing a longitudinal element including a portion having a selected curvature; disposing the longitudinal element with the implant cavities such that the portion is disposed in a selected orientation relative to the vertebrae; and moving a first element of at least one of the fasteners relative to the portion such that a second element of the at least one of the fasteners derotates the vertebrae while maintaining the portion in the selected orientation. Systems and implants are disclosed.

Abstract: A dynamic stabilization system including a dynamic rod with a first and second coupler assemblies, a pre-tensioned central cord and a flexible bumper, which are coupled to the bony structures of the spine by way of pedicle screws for use in spinal fixation surgery.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.

Abstract: Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

Abstract: The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.