Patents by Inventor Neel Satish Joshi

Neel Satish Joshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11098133
    Abstract: Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: August 24, 2021
    Inventors: Anna M. Duraj-Thatte, Noémie-Manuelle Dorval Courchesne, Neel Satish Joshi
  • Publication number: 20210163558
    Abstract: Disclosed herein are engineered bacteria that manufacture biofilms from bacterial amyloid structures. These biofilms and biofilm matrices are capable of generating fibrous proteinaceous networks and being used as 3D-printing inks.
    Type: Application
    Filed: June 21, 2019
    Publication date: June 3, 2021
    Inventors: Arjirios Sourlis, Anna Duraj-Thatte, Avinash Manjula Basavanna, Neel Satish Joshi
  • Publication number: 20210128790
    Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
    Type: Application
    Filed: September 15, 2020
    Publication date: May 6, 2021
    Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander Stafford
  • Patent number: 10995114
    Abstract: Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers thing films by, for example, disassembly and re-assembly, are disclosed herein.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: May 4, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne, Anna M. Duraj-Thatte, Peter Q. Nguyen
  • Patent number: 10821208
    Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: November 3, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander G. Stafford
  • Publication number: 20200291078
    Abstract: Methods of making recombinant secretion of silk and silk-amyloid proteins using bacteria are provided.
    Type: Application
    Filed: November 18, 2016
    Publication date: September 17, 2020
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen
  • Publication number: 20200255480
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Application
    Filed: December 13, 2019
    Publication date: August 13, 2020
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Publication number: 20200248190
    Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
    Type: Application
    Filed: February 10, 2020
    Publication date: August 6, 2020
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Anna M. Duraj-Thatte, Pichet Praveschotinunt
  • Publication number: 20200197526
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: December 6, 2019
    Publication date: June 25, 2020
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Alexandre Barros E Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel Satish Joshi, David J. Mooney
  • Patent number: 10550160
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: February 4, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Publication number: 20190315799
    Abstract: Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers thing films by, for example, disassembly and re-assembly, are disclosed herein.
    Type: Application
    Filed: May 16, 2017
    Publication date: October 17, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne, Anna M. Duraj-Thatte, Peter Q. Nguyen
  • Publication number: 20190201457
    Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
    Type: Application
    Filed: August 31, 2017
    Publication date: July 4, 2019
    Inventors: Peter Q. Nguyen, Neel Satish Joshi
  • Publication number: 20190127490
    Abstract: Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.
    Type: Application
    Filed: May 19, 2017
    Publication date: May 2, 2019
    Inventors: Anna M. Duraj-Thatte, Noémie-Manuelle Dorval Courchesne, Neel Satish Joshi
  • Publication number: 20180334483
    Abstract: Methods of making engineered protein-based materials, nanofibers, and biofilms from bacterial amyloid-based structures that are capable of mediating long-range electron transport are provided.
    Type: Application
    Filed: November 18, 2016
    Publication date: November 22, 2018
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne
  • Publication number: 20180186840
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Application
    Filed: November 9, 2017
    Publication date: July 5, 2018
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Patent number: 9815871
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 14, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen, Zsofia Magarian
  • Publication number: 20170189581
    Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
    Type: Application
    Filed: April 6, 2015
    Publication date: July 6, 2017
    Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander G. Stafford
  • Patent number: 9682168
    Abstract: The disclosed subject matter can provide a nanotube-reinforced polymer composite material comprising a plurality of nanotubes, each nanotube being formed of a plurality of cyclic peptide molecules, disposed within a polymer matrix, such as a biodegradable polymer matrix. A cyclic polymer, such as a cyclic 8-mer, composed of amino acid residues of alternating absolute configurations (D/L, R/S), can self-assemble into nanotubes useful for preparation of the composite polymer material of the invention. For example, the cyclic peptide (QL)4, wherein the glutamine and leucine residues are of opposite absolute configuration, self-assembles into nanotubes, which when formed into a reinforced polymer composite including poly(caprolactone), provides a biocompatible material of greater tensile strength and Young's modulus compared to the poly(caprolactone) material alone. The nanotubes can be prepared by a vapor equilibration technique or by a solvent-nonsolvent precipitation technique.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: June 20, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Daniel James Rubin
  • Publication number: 20160185828
    Abstract: Described herein are methods and compositions relating to engineered curii fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms. In one aspect, described herein is an engineered CsgA polypeptide, comprising a CsgA polypeptide with a C-terminal display tag flanking the CsgA polypeptide; wherein the display tag comprises an activity polypeptide and a linker sequence. In some embodiments, the display tag and/or the activity polypeptide comprises a polypeptide selected from the group consisting of metal binding domain (MBD); Spy Tag; graphene binding (GBP); carbon nanotube binding (CBP); gold binding (A3); CT43; FLAG; Z8; E14; QBP1; CLP12; and AFP8.
    Type: Application
    Filed: April 23, 2014
    Publication date: June 30, 2016
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen, Zsofia Botyanszki
  • Publication number: 20140369954
    Abstract: The disclosed subject matter can provide a nanotube-reinforced polymer composite material comprising a plurality of nanotubes, each nanotube being formed of a plurality of cyclic peptide molecules, disposed within a polymer matrix, such as a biodegradable polymer matrix. A cyclic polymer, such as a cyclic 8-mer, composed of amino acid residues of alternating absolute configurations (D/L, R/S), can self-assemble into nanotubes useful for preparation of the composite polymer material of the invention. For example, the cyclic peptide (QL)4, wherein the glutamine and leucine residues are of opposite absolute configuration, self-assembles into nanotubes, which when formed into a reinforced polymer composite including poly(caprolactone), provides a biocompatible material of greater tensile strength and Young's modulus compared to the poly(caprolactone) material alone. The nanotubes can be prepared by a vapor equilibration technique or by a solvent-nonsolvent precipitation technique.
    Type: Application
    Filed: November 26, 2012
    Publication date: December 18, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Daniel James Rubin