Abstract: A method and apparatus for maintaining data consistency between a subject and an observer. In one embodiment, an observer configures an aspect with a desired update type indicator, and then instructs the aspect to attach itself to a subject. The subject sends an update to the aspect when it changes state. The aspect interrogates the update, generates a update type indication, and selectively communicates an update based on a comparison between the desired type indication and the update type indicator. Some embodiments may also selectively modify and accumulate the update.

Abstract: The present inventon relates generally to genetic polymorphisms in the Van Buchem-scierosteosis disease region. In particular, the present invention relates to genetic polymorphisms in the Van Buchem-sclerosteosis disease region that are associated with disorders resulting in either net excess bone formation or insufficient bone formation in humans. Furthermore, isolated nucleic acid molecules encoding human osteolevin are provided. Osteolevin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.

Abstract: A method and apparatus for maintaining data consistency between a subject and an observer. In one embodiment, an observer configures an aspect with a desired update type indicator, and then instructs the aspect to attach itself to a subject. The subject sends an update to the aspect when it changes state. The aspect interrogates the update, generates a update type indication, and selectively communicates an update based on a comparison between the desired type indication and the update type indicator. Some embodiments may also selectively modify and accumulate the update.