Patents by Inventor Neelakandha S. Mani

Neelakandha S. Mani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR SYNTHESIZING PHOSPHONIC AND PHOSPHINIC ACID COMPOUNDS
    Publication number: 20120259130
    Abstract: The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
    Type: Application
    Filed: June 19, 2012
    Publication date: October 11, 2012
    Inventors: Luigi Anzalone, Daniel J. Pippel, Neelakandha S. Mani, Penina Feibush, IIias K. Dorziotis, Stefan Horns, Frank J. Villani, JR.
  • Substituted pyrrolidine amides as modulators of the histamine Hreceptor
    Patent number: 8236792
    Abstract: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: August 7, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nicholas I Carruthers, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, Daniel J. Pippel, Chandravadan R. Shah, Akinola Soyode-Johnson, Emily M. Stocking, Lana Young
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20120184740
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for synthesizing phosphonic and phosphinic acid compounds
    Patent number: 8222431
    Abstract: The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: July 17, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Luigi Anzalone, Daniel J. Pippel, Neelakandha S. Mani, Penina Feibush, Ilias K. Dorziotis, Stefan Horns, Frank J. Villani, Jr.
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatgives
    Publication number: 20120178932
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 12, 2012
    Inventors: Sergio CESCO-CANCIAN, Jeffrey S. GRIMM, Neelakandha S. MANI, Christopher M. MAPES, David C. PALMER, Daniel J. PIPPEL, Tong XIAO, Diego BROGGINI, Susanne LOCHNER
  • PROCESS FOR THE PREPARATION OF CATHEPSIN S INHIBITORS
    Publication number: 20120142928
    Abstract: Inhibitors of Cathepsin S enzyme and their synthetic processes.
    Type: Application
    Filed: August 11, 2010
    Publication date: June 7, 2012
    Applicant: Janssen Pharmaceutica NV
    Inventors: Jimmy T. Liang, Neelakandha S. Mani
  • PROCESS FOR THE PREPARATION OF HISTAMINE H3 RECEPTOR MODULATORS
    Publication number: 20120029189
    Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
    Type: Application
    Filed: March 17, 2010
    Publication date: February 2, 2012
    Inventors: Diego Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
  • NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
    Publication number: 20120029191
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 2, 2012
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles
    Patent number: 8071782
    Abstract: This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: December 6, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Xiaohu Deng, Neelakandha S. Mani
  • Processes for the preparation of cyclopropyl-amide derivatives
    Patent number: 8063206
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: November 22, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
    Publication number: 20110218338
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
    Type: Application
    Filed: April 11, 2011
    Publication date: September 8, 2011
    Inventors: Hui Cai, Frank Chavez, James P. Edwards, Anne E. Fitzgerald, Jing Liu, Neelakandha S. Mani, Danielle K. Neff, Michele C. Rizzolio, Brad M. Savall, Deborah M. Smith, Jennifer D. Venable, Jianmei Wei, Ronald L. Wolin
  • Synthesis of unsaturated piperidines from piperidones with a silyl reagent
    Patent number: 8013157
    Abstract: Syntheses of unsaturated piperidines from piperidones through a silyl piperidine reagent via the Shapiro reaction and palladium-catalyzed cross-coupling reactions with organo halides.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 6, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, Christie Morrill
  • Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
    Publication number: 20110190503
    Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
    Type: Application
    Filed: March 2, 2011
    Publication date: August 4, 2011
    Inventors: Genesis M. BACANI, Diego BROGGINI, Eugene Y. CHEUNG, Christa C. CHROVIAN, Xiaohu DENG, Anne M. FOURIE, Laurent GOMEZ, Cheryl A. GRICE, Aaron M. KEARNEY, Adrienne M. LANDRY-BAYLE, Alice LEE-DUTRA, Jimmy T. LIANG, Susanne LOCHNER, Neelakandha S. MANI, Alejandro SANTILLÁN, JR., Kathleen SAPPEY, Kia SEPASSI, Virginia M. TANIS, Alvah T. WICKBOLDT, John J. M. WIENER, Hartmut ZINSER
  • 2-Aminopyrimidine modulators of the histamine H4 receptor
    Publication number: 20110160452
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: March 8, 2011
    Publication date: June 30, 2011
    Inventors: Hui Cai, Frank Chavez, James P. Edwards, Anne E. Fitzgerald, Jing Liu, Neelakandha S. Mani, Danielle K. Neff, Michele C. Rizzolio, Brad M. Savall, Deborah M. Smith, Jennifer D. Venable, Jianmai Wei, Ronald L. Wolin
  • Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
    Publication number: 20110159563
    Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
    Type: Application
    Filed: March 2, 2011
    Publication date: June 30, 2011
    Inventors: Genesis M. Bacani, Diego Broggini, Eugene Y. Cheung, Christa C. Chrovian, Xiaohu Deng, Anne M. Fourie, Laurent Gomez, Cheryl A. Grice, Aaron M. Kearney, Adrienne M. Landry-Bayle, Alice Lee-Dutra, Jimmy T. Liang, Susanne Lochner, Neelakandha S. Mani, Alejandro Santillán, JR., Kathleen Sappey, Kia Sepassi, Virginia M. Tanis, Alvah T. Wickboldt, John J. M. Wiener, Hartmut Zinser
  • 2-Aminopyrimidine modulators of the histamine H4 receptor
    Publication number: 20110160451
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: March 8, 2011
    Publication date: June 30, 2011
    Inventors: Hui CAI, Frank CHAVEZ, James P. EDWARDS, Anne E. FITZGERALD, Jing LIU, Neelakandha S. MANI, Danielle K. NEFF, Michele C. RIZZOLIO, Brad M. SAVALL, Deborah M. SMITH, Jennifer D. VENABLE, Jianmei WEI, Ronald L. WOLIN
  • Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
    Patent number: 7939527
    Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: May 10, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Genesis M. Bacani, Diego Broggini, Eugene Y. Cheung, Christa C. Chrovian, Xiaohu Deng, Laurent Gomez, Cheryl A. Grice, Aaron M. Kearney, Adrienne M. Landry-Bayle, Alice Lee-Dutra, Jimmy T. Liang, Susanne Lochner, Neelakandha S. Mani, Alejandro Santillán, Jr., Kathleen Sappey, Kia Sepassi, Virginia M. Tanis, Alvah T. Wickboldt, John J. M. Wiener, Hartmut Zinser
  • NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
    Publication number: 20100286391
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: July 20, 2010
    Publication date: November 11, 2010
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20100267701
    Abstract: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 21, 2010
    Inventors: John M. Keith, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, John E. Mills, Chennagiri R. Pandit, Frank J. Villani, Hua Zhong
  • Processes for the preparation of cyclopropyl-amide derivatives
    Patent number: 7795426
    Abstract: The present invention relates to processes for the preparation of cyclopropyl-amine derivatives of formula (II), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: September 14, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian