Patents by Inventor Neeraj J. Agrawal

Neeraj J. Agrawal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific antibodies with cleavable C-terminal charge-paired tags
    Patent number: 12384849
    Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: August 12, 2025
    Assignee: AMGEN INC.
    Inventors: John K. Kawooya, Alex W. Jacobitz, Christopher Mohr, Stephen Smith, Kevin Graham, Ray Lieh Yoon Low, Oliver Thiel, Dante Romanini, Victoria Wagner, Neeraj J. Agrawal
  • BISPECIFIC ANTIBODIES WITH CLEAVABLE C-TERMINAL CHARGE-PAIRED TAGS
    Publication number: 20250197518
    Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
    Type: Application
    Filed: January 15, 2025
    Publication date: June 19, 2025
    Applicant: AMGEN INC.
    Inventors: John K. KAWOOYA, Alex W. JACOBITZ, Christopher MOHR, Stephen SMITH, Kevin GRAHAM, Ray Lieh Yoon LOW, Oliver THIEL, Dante ROMANINI, Victoria WAGNER, Neeraj J. AGRAWAL
  • BISPECIFIC ANTIBODIES WITH CLEAVABLE C-TERMINAL CHARGE-PAIRED TAGS
    Publication number: 20220089756
    Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
    Type: Application
    Filed: May 8, 2019
    Publication date: March 24, 2022
    Inventors: John K. KAWOOYA, Alex W. JACOBITZ, Christopher MOHR, Stephen SMITH, Kevin GRAHAM, Ray Lieh Yoon LOW, Oliver THIEL, Dante ROMANINI, Victoria WAGNER, Neeraj J. AGRAWAL
  • MUTATED PIGGYBAC TRANSPOSASE
    Publication number: 20220064610
    Abstract: PiggyBac transposases engineered to increase stability in a cell. The engineered piggyBac transposases are useful for stably transforming cells, cell line development, genome modification, and improving titer of recombinant proteins, among other uses.
    Type: Application
    Filed: December 9, 2019
    Publication date: March 3, 2022
    Applicant: AMGEN INC.
    Inventors: Neeraj J. AGRAWAL, Kristine M. DARIS, Jennitte L. STEVENS, Huong Thi Ngoc LE, Noelia Blanco TALAVAN
  • Methods to identify amino acid residues involved in macromolecular binding and uses therefor
    Patent number: 10431325
    Abstract: The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: October 1, 2019
    Assignees: NOVARTIS AG, MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)
    Inventors: Neeraj J. Agrawal, Bernhard Helk, Bernhardt L. Trout
  • METHODS TO IDENTIFY AMINO ACID RESIDUES INVOLVED IN MACROMOLECULAR BINDING AND USES THEREFOR
    Publication number: 20150205912
    Abstract: The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 23, 2015
    Applicants: NOVARTIS AG, MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)
    Inventors: Neeraj J. Agrawal, Bernhard Helk, Bernhardt L. Trout