Patents by Inventor Negin Mokhtari

Negin Mokhtari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED BONE MARROW MODEL
    Publication number: 20220238042
    Abstract: The present invention provides engineered models that recapitulate bone marrow, including the endosteal and vascular niches, and bone marrow diseases. The models can be implemented in many ways including, but not limited to, on a microfluidic device or microfluidic chip, a culture model in vitro, and as an implantable model in vivo. Also provided are methods of using these models, including high-throughput systems and in personalized medicine analysis. Also provided are devices for use in the provided bone marrow models, and kits that include at least one such device.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 28, 2022
    Applicant: Oregon Health & Science University
    Inventors: Negin Mokhtari, Danielle Konetski, Keith Beadle, Anthony Tahayeri, Elie Traer, Luiz Bertassoni, Yu-Jui Chiu, Jesus Bueno Alvarez, Raviraj Thakur
  • Nano-scale delivery device and uses thereof
    Patent number: 11357830
    Abstract: Disclosed is a delivery device for delivering a payload, including a biological, chemical or biochemical substance, to a subject. The delivery device has a nanoparticle loaded with the payload, and porous coating structure over the loaded nanoparticle to prevent the payload from escaping the delivery device, while also preserving the activity of the payload and increasing effective utilization of the payload. Also disclosed is a delivery device for delivering a payload, including a natural virus, recombinant virus, or engineered virus. Also disclosed is a delivery device that has a liposome loaded with the payload and a biocompatible surface coating over the loaded liposome. Also disclosed are methods of fabricating the delivery devices and methods of using the delivery devices in treating health conditions, such as cancer, or in diagnostic applications.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: June 14, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TROGENEX, INC.
    Inventors: Sadik Esener, Negin Mokhtari, Mukanth Vaidyanathan, Ya-San Yeh, Ajay Sapre, Bartu Ahiska
  • NANO-SCALE DELIVERY DEVICE AND USES THEREOF
    Publication number: 20170252413
    Abstract: Disclosed is a delivery device for delivering a payload, including a biological, chemical or biochemical substance, to a subject. The delivery device has a nanoparticle loaded with the payload, and porous coating structure over the loaded nanoparticle to prevent the payload from escaping the delivery device, while also preserving the activity of the payload and increasing effective utilization of the payload. Also disclosed is a delivery device for delivering a payload, including a natural virus, recombinant virus, or engineered virus. Also disclosed is a delivery device that has a liposome loaded with the payload and a biocompatible surface coating over the loaded liposome. Also disclosed are methods of fabricating the delivery devices and methods of using the delivery devices in treating health conditions, such as cancer, or in diagnostic applications.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 7, 2017
    Inventors: Sadik Esener, Negin Mokhtari, Mukanth Vaidyanathan, Ya-San Yeh, Ajay Sapre, Bartu Ahiska