Patents by Inventor Neil A. Feldstein

Neil A. Feldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
    Patent number: 4667043
    Abstract: The present invention provides compounds having the structure: ##STR1## wherein R.sup.1 represents alkoxy or aralkoxy, R.sup.2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R.sup.1 and R.sup.2 taken together represent the group --O--CH.sub.2 --O--, R.sup.3 represents hydrogen, alkyl, aralkyl, acyl or a protecting group, Y represents Cl, Br, I or a leaving group, and X represents Cl, Br or I.
    Type: Grant
    Filed: January 19, 1982
    Date of Patent: May 19, 1987
    Assignee: The University of Rochester
    Inventors: Andrew S. Kende, Dennis P. Curran, Margaret L. King, Neil A. Feldstein
  • Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
    Patent number: 4391982
    Abstract: The present invention provides compounds having the structure: ##STR1## wherein R.sup.1 represents alkoxy or aralkoxy, R.sup.2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R.sup.1 and R.sup.2 taken together represent the group --O--CH.sub.2 --O--, R.sup.3 represents hydrogen, alkyl, aralkyl, acyl or a protecting group, Y represents Cl, Br, I or a leaving group; and X represents Cl, Br or I.The present invention also provides a process for preparation of compounds VI in a single step wherein X and Y are the same and represent Cl, Br, ,or I, and R.sup.3 is as previously defined except that in this instance, it does not represent a protecting group.According to another aspect of the present invention there are provided compounds VII-a and VII-b having the structure: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as previously defined, j is an integer having a value of 0 or 1, Z.sup.1 represents a non-reacting electron withdrawing group, and Z.sup.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: July 5, 1983
    Assignee: The University of Rochester
    Inventors: Andrew S. Kende, Dennis P. Curran, Margaret L. King, Neil A. Feldstein
  • Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
    Patent number: 4294763
    Abstract: The present invention provides compounds having the structure: ##STR1## wherein R.sup.1 represents alkoxy or aralkoxy, R.sup.2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R.sup.1 and R.sup.2 taken together represent the group --O--CH.sub.2 --O--, R.sup.3 represents hydrogen, alkyl, aralkyl, acyl or a protecting group, Y represents Cl, Br, I or a leaving group; and X represents Cl, Br or I.The present invention also provides a process for preparation of compounds VI in a single step wherein X and Y are the same and represent Cl, Br, or I, and R.sup.3 is as previously defined except that in this instance, it does not represent a protecting group.According to another aspect of the present invention there are provided compounds VII-a and VII-b having the structure: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as previously defined, j is an integer having a value of 0 or 1, Z.sup.1 represents a non-reacting electron withdrawing group, and Z.sup.
    Type: Grant
    Filed: March 5, 1980
    Date of Patent: October 13, 1981
    Assignee: University of Rochester
    Inventors: Andrew S. Kende, Dennis P. Curran, Margaret L. King, Neil A. Feldstein