Abstract: The present invention relates to antibody-drug conjugates comprising (i) an antibody or antigen-binding fragment thereof, (ii) a polymer comprising a particular repeat unit comprising an amino acid derivative, which is covalently bound to one or more biologically active moieties, such as small molecule drugs, optionally via a linker, and (iii) a polymer-antibody linker moiety which is covalently bound to both the polymer and the antibody or antigen-binding fragment thereof. Additionally, the present invention relates to pharmaceutical compositions comprising the antibody-drug conjugates and to use of the antibody-drug conjugates in medicine.

Abstract: A system is provided for automatically removing deceased fish from an aquaculture cage. The system may include an underwater robotic vehicle configured to traverse the aquaculture cage to collect mortalities. The mortalities, once collected, may be brought to a system dock and then removed from the cage.

Abstract: A system and method for automatically harvesting fish from an aquaculture cage is provided. Underwater robotic rovers draw out a large net from a protective enclosure. The net is manipulated to corral or concentrate the fish into a smaller volume. Transponders installed at strategic locations throughout the cage facilitate navigation of the rovers.

Abstract: A system is provided for automatically removing deceased fish from an aquaculture cage. The system may include an underwater robotic vehicle configured to traverse the aquaculture cage to collect mortalities. The mortalities, once collected, may be brought to a system dock and then removed from the cage.

Abstract: A system and method for automatically harvesting fish from an aquaculture cage is provided. Underwater robotic rovers draw out a large net from a protective enclosure. The net is manipulated to corral or concentrate the fish into a smaller volume. Transponders installed at strategic locations throughout the cage facilitate navigation of the rovers.

Abstract: A fish-growing cage, of the type having a central spar or other buoyancy chamber for deploying surrounding cage netting attached thereto, has a central spar configured in an elongated shape with at least two enclosed sections at opposite ends thereof in which buoyancy is altered by changes of air and water therein so as to cause a shift of center of balance of the cage that enables the central spar with the cage netting to be rotated and inverted. The cage can be raised from its normal submerged position to an emergent position where the top half can be subject to a maintenance operation, then submerged, inverted, and raised to the emergent position again so that the bottom half can be treated. The inverting cage facilitates cleaning of the netting and air-drying, and also allows for bath-treatment, crowding harvesting, or other handling of the fish.

Abstract: An internal net in an inverted cone shape is provided inside a fish-growing cage of the type having a central spar for deploying surrounding outside cage netting attached thereto. The internal net has netting with an open mouth suspended between a higher point on the outer netting of the cage and an apex of the netting attached to a lower point on the central spar. The fish become concentrated in the internal net when the cage is raised from a normal, submerged position to at least a partly emergent position from the water, thereby allowing the fish to be harvested from the apex with a harvest pipe or for or other management operations, such as grading or bath treating.