Abstract: The invention features methods of treating a SARS-CoV-2 infection in a subject, the method comprising administering to the subject an effective amount of sepiapterin or a pharmaceutically acceptable salt thereof.

Abstract: A military vehicle includes an engine, an energy storage system, an accessory drive coupled to the engine and including an air compressor and a first motor, a second motor coupled to an axle, and a clutch positioned between the engine and the second motor. The clutch is spring-biased into engagement with the engine and pneumatically disengaged by an air supply selectively provided thereto based on operation of the air compressor. In an engine mode, (i) the clutch does not receive the air supply such that the engine is coupled to the second motor and (ii) the engine drives (a) the accessory drive and (b) the axle through the second motor. In the electric mode, (i) the first motor drives the air compressor to compress air to facilitate supplying the air supply to the clutch to disengage the clutch and decouple the engine from the second motor and (ii) the second motor drives the axle.

Abstract: The invention features methods of treating glioblastoma in a subject, the method comprising administering to the subject an effective amount of sepiapterin or a pharmaceutically acceptable salt thereof.

Abstract: An audio filtering and power extraction apparatus for filtering out audio signal and extracting power from a combined signal and direct-current power line, with an input configured to couple to a combined signal and direct-current power line, a filtering extractor system functionally coupled to the input, a DC sensing switch circuit, and a second order low-pass filter functionally coupled to the DC sensing switch circuit, the second order low-pass filter including, an inductor, a capacitor and resistor in series with each other, and an output functionally coupled to an output of the filtering extractor system and through which output extracted power is provided.

Abstract: Techniques for displaying workflow responses based on determining topics associated with user requests are discussed herein. In some examples, a user may post a request (e.g., question) to a virtual space (e.g., a channel, thread, board, etc.) of a communication platform. The communication platform may input the request into a machine learning model trained to identify topics associated with the request and confidence levels associated with topics. In such examples, the communication platform may associate a topic with the user request based on the confidence level of the topic. In some examples, the communication platform may determine that the topic is associated with a graphical identifier (e.g., emoji). The communication platform may cause the graphical identifier to be displayed to the virtual space within which the user request was posted. In response to displaying the graphical identifier, the communication platform may display a workflow response to the virtual space.

Abstract: A refuse vehicle includes a chassis, a body coupled to the chassis, the body defining a refuse compartment, a tailgate detachably coupled to the body, and an electrical energy system, and a detachable electrical connection. A first portion of the electrical energy system is coupled to the tailgate. A second portion of the electrical energy system is coupled to the body. The detachable electrical connection is between the first portion and the second portion of the electrical energy system.

Abstract: An electrical assembly including a grounding mechanism and an electrical device, the grounding mechanism including a support longitudinal member and a switch contact member, the switch contact member arranged in or on the support longitudinal member, the switch contact member configured to be connected in use to ground, the electrical device including an electrical terminal, wherein the support longitudinal member is configured to be slidable between: a first position in which the switch contact member is separated from the electrical terminal so that the switch contact member is electrically disconnected from the electrical device and a second position in which the switch contact member is in contact with the electrical terminal so that the switch contact member is electrically connected to the electrical device.

Abstract: A method of data transfer from a tenant to a service provider comprises encrypting the data with a public key of a key pair generated by a secure device within the service provider system. The data thus cannot be accessed by the service provider during transmission. The data is generated with a corresponding access control list, which specifies that a valid certificate must be presented in order to grant a particular use of the data once stored. The tenant can thus retain control of the use of the data even though it has been transferred out of the tenant system. A method of controlling use of data securely stored in the service provider system comprises issuing a use certificate having an expiry time to the party requesting use of the data. The use certificate must be validated before use of the stored data is granted. This enables the tenant to grant use of the stored data for a limited time period.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: The derail warning system may include a solar-powered LED indicator for derail or switch. The derail warning system may also include an orientation sensor that automatically turns on depending on the orientation of the derail (up or down), derail metal flag, or switch indicator flag. The derail warning system may bring more visibility with a 360-degree LED that is solar powered and may detect orientation and turn on based on the position of the derail, switch, or flag. The derail warning system may use a unique acceleration sensor or g-sensor that can detect orientation movement and automatically turn on or off and be fully charged to operate day or night. The derail warning system may also include a data-logging microprocessor to determine a time stamp of position and location.

Abstract: The present invention features methods for treating Parkinson's disease using sepiapterin, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: A frangible shunt link assembly includes a frangible link configured to conductively couple a current collector coupled with a vehicle and one or more components of the vehicle. The frangible link is configured to break responsive to the current collector being at least partially separated from the vehicle to interrupt a conductive connection between the current collector and the one or more components of the vehicle.

Abstract: Trajectory estimate for a sub-sonic projectile can be derived from sampling a wake contribution of an acoustic signal detected at a multi-detector array. The wake contribution is sampled, in time, and the samples are processed to determine a bearing estimate for the projectile from which the acoustic wake derives.

Abstract: The invention features methods of reducing the blood phenylalanine concentration in a subject by administering sepiapterin, or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments and methods relate to pulling and installing a product line along an underground arcuate path beneath an obstacle, including pulling the product line for an extended length (i.e. a length that might otherwise be deemed impracticable) along the underground arcuate path beneath the obstacle. Embodiments also relate to a pulling apparatus for installing a product line using a casing along an underground arcuate path beneath an obstacle, having a casing pull head connected to the casing, a product line pull head assembly connected to the product line, and a pull bracket connected to the product line pull head assembly and to the casing pull head sleeve frame.

Abstract: In one embodiment, the invention discloses a method for adapting educational content. The method comprises generating data for each of a plurality of students, the data pertaining to an aspect of the student's interaction with an educational system; combining the generated data to form a combined data set; analyzing the combined data set to identify clusters, each representing similar students according to a mathematical model; and adapting the educational system to provide a customized learning experience for a particular student based on an identified cluster.

Abstract: The invention provides methods for treating radiation exposure in a subject by administering sepiapterin, tetrahydrobiopterin, or dihydrobiopterin.

Abstract: A shunt apparatus includes a mounting bracket assembly configured for connection to a vehicle, an actuator connected to the mounting bracket assembly, and a shoe unit connected to the actuator. The actuator is controllable to move the shoe unit to an extended position where a conductive shoe of the shoe unit is positioned to contact a conductive first running surface on which the vehicle travels. The shoe unit includes a resilient biasing assembly that is configured to exert a force on the shoe, to press the shoe against the running surface during movement of the vehicle. Two of the shunt apparatuses may be attached to opposite sides of the vehicle. The shoes of the two shunt apparatuses are electrically connected to one another by an electrical cable. When the shoes are brought into contact with respective running surfaces, the running surfaces are electrically shunted for vehicle signaling purposes or otherwise.

Abstract: The derail warning system may include a solar-powered LED indicator for derail or switch. The derail warning system may also include an orientation sensor that automatically turns on depending on the orientation of the derail (up or down), derail metal flag, or switch indicator flag. The derail warning system may bring more visibility with a 360-degree LED that is solar powered and may detect orientation and turn on based on the position of the derail, switch, or flag. The derail warning system may use a unique acceleration sensor or g-sensor that can detect orientation movement and automatically turn on or off and be fully charged to operate day or night. The derail warning system may also include a data-logging microprocessor to determine a time stamp of position and location.