Patents by Inventor Neil B. Graham

Neil B. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5439966
    Abstract: A temperature- and/or polar fluid-sensitive device which comprises a mechanically strained semi-crystalline hydrophilic polymer.
    Type: Grant
    Filed: January 7, 1993
    Date of Patent: August 8, 1995
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Marion E. McNeill
  • Patent number: 5382270
    Abstract: The invention provides a method of plant growing in which method one or more plants are grown in a growing medium comprising hydrogel particles charged with aqueous nutrient solution for the plant and plants, the growing medium being housed in a substantially water-impermeable container and the plants extending out of the container, and, when the water content within the hydrogel particles falls below a predetermined level, introducing further nutrient solution into the container.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: January 17, 1995
    Assignee: University of Strathclyde
    Inventors: Neil B. Graham, Robert A. K. Szmidt, Ralph C. Kirkwood
  • Patent number: 5273066
    Abstract: Control valves are known which incorporate moisture sensitive material to control the flow of fluid through the valve. Described herein is control valve (1) which incorporates a moisture sensitive material (4) in contact with and responsive to increasing environment moisture levels. The material (4) acts on a moisture impermeable flexible film (5) to shut off a fluid flow connection between an inlet (6) and an outlet (7), the material (4) being sealed from the inlet (6) and outlet (7) by the film (5). Also the invention provides a method of plant growing in which method one or more plants are grown in a growing medium comprising hydrogel particles charge with aqueous nutrient solution for the plant or plants, the growing medium being housed in a substantially water-impermeable container and the plants extending out of container, and, when the water content within the hydrogel particles falls below a predetermined level, introducing further nutrient solution into the container.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: December 28, 1993
    Inventors: Neil B. Graham, Donald S. Ross
  • Patent number: 5236966
    Abstract: Linear chain extended poly(alkylene oxides) having at least a portion of hydrophobic hydrogen bonding chain extending groups are soluble in at least one solvent and swellable in water. The chain extending groups preferably comprise a urea linkage and can be produced by the reaction of an amine with an isocyanate. The extended polymers and their solutions may readily be fabricated into controlled release compositions, e.g. for the release of pharmaceuticals.
    Type: Grant
    Filed: February 6, 1992
    Date of Patent: August 17, 1993
    Assignee: British Technology Group Limited
    Inventors: Neil B. Graham, Christopher R. Moran
  • Patent number: 5147646
    Abstract: An envelope having flexible water-permeable or porous walls contains a quantity of particulate water-insoluble hydrogel. The quantity of hydrogel in the envelope is such that, when the hydrogel is fully swollen at 20.degree. C., its volume is at least 66%, preferably at least 100%, of the maximum non-stretched internal volume of the envelope. Thus, the envelope according to the invention is limp and floppy under dry conditions but in a wet environment the hydrogel absorbs water and swells accordingly causing the envelope to swell and take on a more rigid configuration. The envelope is particularly useful for the administration of sustained release pharmaceutically or veterinarily active ingredients. Thus the limp dry envelope may for example be rolled up for introduction through the throat but will swell up and therefore be retained in the stomach for sustained release of the active ingredient therein.
    Type: Grant
    Filed: September 16, 1991
    Date of Patent: September 15, 1992
    Assignee: National Research Development Corporation
    Inventor: Neil B. Graham
  • Patent number: 5096896
    Abstract: A non-crosslinked derivative formable by reacting at least one substituted or unsubstituted, saturated or unsaturated, mono-, di- or poly-carboxy, hydroxy or mercapto hydrocarbon with at least one cyclic unsaturated (thio)ether.
    Type: Grant
    Filed: January 10, 1989
    Date of Patent: March 17, 1992
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Robert E. Howells, David A. Wood, Koritala P. Rao
  • Patent number: 5079009
    Abstract: A controlled release composition comprising an active substance other than a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1000 which comprises polyethylene oxide and are cross-linked through urethane groups.
    Type: Grant
    Filed: January 2, 1990
    Date of Patent: January 7, 1992
    Assignee: National Research Development Corporation
    Inventors: Mostyn P. Embrey, Neil B. Graham
  • Patent number: 5017382
    Abstract: A process for the preparation of a controlled release composition comprising a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1,000 which comprise polyethylene oxide and are cross-linked through urethane groups.
    Type: Grant
    Filed: January 23, 1990
    Date of Patent: May 21, 1991
    Assignee: National Research Development Corporation
    Inventors: Mostyn P. Embrey, Neil B. Graham
  • Patent number: 4973304
    Abstract: A device for the sustained release of active substance comprises a wall defining a cavity for the reception of active substance, the wall being of impermeable material and having one or more ports therethrough. Sections of hydrogel material are within the cavity, the hydrogel, in use, being swollen to cover the ports in the cavity wall. Active ingredient is released from the container only through the hydrogel covering the ports. In this way sustained and controlled release of the active substance from the device is obtained.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: November 27, 1990
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Ernst R. Huehns, Marion E. McNeill
  • Patent number: 4931288
    Abstract: A controlled release composition comprising a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1,000 which comprise polyethylene oxide and are cross-linked through urethane groups.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: June 5, 1990
    Assignee: Lloyds Bank PLC
    Inventors: Mostyn Embrey, Neil B. Graham
  • Patent number: 4894238
    Abstract: A controlled release composition comprising an active substance other than a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1000 which comprises polyethylene oxide and are cross-linked through urethane groups.
    Type: Grant
    Filed: June 14, 1988
    Date of Patent: January 16, 1990
    Assignee: National Research Development Corporation
    Inventors: Mostyn P. Embry, Neil B. Graham
  • Patent number: 4882166
    Abstract: A composition which comprises at least one solid or liquid particle comprising at least one active substance, the or a plurality of such particles being encapsulated by the in situ cationic (co)polymerization there on of at least on cationically polymerizable monomer or prepolymer.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: November 21, 1989
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Abdul Rashid, Koritala P. Rao
  • Patent number: 4814182
    Abstract: A controlled release device which comprises:(i) a hydrogel; and incorporated therewith(ii) an active substance,at least part of at least one surface of the device comprising(iii) a layer which is impermeable to aqueous media.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: March 21, 1989
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Marion E. McNeill, David A. Wood
  • Patent number: 4584188
    Abstract: A hydrogel which comprises polymerized moieties derivable from (i) at least one polymerizable cyclic (thio)ether and (ii) at least one hydrophilic homo- or copolymer.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: April 22, 1986
    Assignee: Nationale Research Development Corporation
    Inventor: Neil B. Graham
  • Patent number: 4542176
    Abstract: A process for the preparation of a particulate gel, which process comprises (i) contacting the gel with a swelling agent and (ii) subjecting the swollen gel to shear stress such that the swollen gel is comminuted to particles.
    Type: Grant
    Filed: November 5, 1984
    Date of Patent: September 17, 1985
    Assignee: National Research Development Corporation
    Inventor: Neil B. Graham
  • Patent number: 4528365
    Abstract: A hydrogel which comprises polymerized moieties derivable from (i) at least one polymerizable cyclic (thio)ether and (ii) at least one hydrophilic homo- or copolymer.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: July 9, 1985
    Assignee: National Research Development Corporation
    Inventor: Neil B. Graham
  • Patent number: 4438258
    Abstract: A hydrogel which comprises polymerized moieties derivable from (i) at least one polymerizable cyclic (thio)ether and (ii) at least one hydrophilic homo- or copolymer.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: March 20, 1984
    Assignee: National Research Development Corporation
    Inventor: Neil B. Graham
  • Patent number: 4235686
    Abstract: A polymeric composition which is capable of being shaped and which preferably is in the form of a sheet, the composition being formed by partially reacting a mixture of(a) the precursors of a polyurethane comprising at least one polyfunctional compound capable of reacting with isocyanate groups and at least one polyisocyanate, and,(b) the precursors of a cured polyester resin comprising at least one ethylenically unsaturated polyester and at least one ethylenically unsaturated monomer copolymerizable therewith,and the composition containing at least one alpha, alpha diketone as a photosensitive catalyst.
    Type: Grant
    Filed: November 4, 1977
    Date of Patent: November 25, 1980
    Assignee: Imperial Chemical Industries Limited
    Inventors: Edward C. Dart, Roger C. Roberts, Antony R. Perry, Jozef Nemcek, Neil B. Graham
  • Patent number: 4221779
    Abstract: A pharmaceutical composition of prolonged effect in the treating of Tropical Diseases comprises an organic nitrogen base drug which is effective against diseases such as malaria, dispersed in a polymeric matrix of a copolymer of the compound ##STR1## and a comonomer which contains more than one functional group selected from hydroxy and carboxy groups.
    Type: Grant
    Filed: June 28, 1978
    Date of Patent: September 9, 1980
    Inventor: Neil B. Graham
  • Patent number: 4150108
    Abstract: A medicinal composition comprising a steroid compound entrapped within a polymeric matrix composed of a copolymer of a compound containing two or more groups selected from the group consisting of OH and --COOH groups and a bisdihydropyron of the general ##STR1## wherein R is an organic bridging group which is unreactive to the OH or --COOH groups.The most preferred bridging group is one which contains one or more ester groups. Any bridge which is non-reactive to the comonomer containing the --OH or --COOH groups can be used. Another preferred compound is the product of the added condensation of 2-formyl-3, 4-dihydro-2H-pyron.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: April 17, 1979
    Inventor: Neil B. Graham