Patents by Inventor Neil Christensen
Neil Christensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10077309Abstract: Provided are compositions and methods for use in prophylaxis, therapy and diagnosis of conditions which involve surfactant protein receptors (SPR) including the SPR for surfactant proteins A (SPA). Specific binding partners, including mono-clonal antibodies, for the SP-R210L and SP-R210S isoforms, and methods of using such binding partners are included. Fragments of the monoclonal antibodies, and fusion proteins that contain them are also included. Also provided are methods for prophylaxis and/or therapy for an individual in need thereof by administering to the individual an effective amount of monoclonal antibody or antigen binding fragment thereof. The monoclonal antibodies are bind with specificity to epitopes in one or both of the SP-R2100L and SP-R210S isoforms.Type: GrantFiled: July 14, 2015Date of Patent: September 18, 2018Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Zissis Chroneos, Neil Christensen
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Publication number: 20170158768Abstract: Provided are compositions and methods for use in prophylaxis, therapy and diagnosis of conditions which involve surfactant protein receptors (SPR) including the SPR for surfactant proteins A (SPA). Specific binding partners, including mono-clonal antibodies, for the SP-R210L and SP-R210S isoforms, and methods of using such binding partners are included. Fragments of the monoclonal antibodies, and fusion proteins that contain them are also included. Also provided are methods for prophylaxis and/or therapy for an individual in need thereof by administering to the individual an effective amount of monoclonal antibody or antigen binding fragment thereof. The monoclonal antibodies are bind with specificity to epitopes in one or both of the SP-R2100L and SP-R210S isoforms.Type: ApplicationFiled: July 14, 2015Publication date: June 8, 2017Inventors: Zissis CHRONEOS, Neil CHRISTENSEN
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Patent number: 8435534Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: GrantFiled: December 22, 2010Date of Patent: May 7, 2013Assignee: The Penn State Research FoundationInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Publication number: 20110280885Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: ApplicationFiled: December 22, 2010Publication date: November 17, 2011Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Patent number: 7960361Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: GrantFiled: January 25, 2008Date of Patent: June 14, 2011Assignee: The Penn State Research FoundationInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Publication number: 20110110955Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: ApplicationFiled: September 20, 2010Publication date: May 12, 2011Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Patent number: 7704965Abstract: The invention provides methods and materials related to treating HPV infections (e.g., HPV infections of cutaneous and mucosal epithelial cells) and HPV-associated conditions (e.g., cervical dysplasia, HPV-associated cervical carcinomas, oral mucosal papilloma cancers, laryngeal papilloma cancers).Type: GrantFiled: June 26, 2003Date of Patent: April 27, 2010Assignee: The Penn State Research FoundationInventors: Gary A. Clawson, Wei-Hua Pan, Diane Thiboutot, Neil Christensen
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Publication number: 20090061412Abstract: This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification of individuals at risk for, or having, cervical dysplasia, cervical intraepithelial neoplasia, or cervical cancer.Type: ApplicationFiled: February 20, 2007Publication date: March 5, 2009Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Christopher D. Gocke, Neil Christensen
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Publication number: 20080206255Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: ApplicationFiled: January 25, 2008Publication date: August 28, 2008Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Publication number: 20080166374Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: ApplicationFiled: January 25, 2008Publication date: July 10, 2008Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Publication number: 20080131448Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: ApplicationFiled: January 7, 2008Publication date: June 5, 2008Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Patent number: 7338929Abstract: A method for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R?2 in the subject. A composition for stimulating a immune response against IL-13R?2 in a subject having or at risk for developing a disease having cells expressing IL-13R?2 includes an isolated agent that can stimulate immune response against IL-13?2.Type: GrantFiled: March 22, 2002Date of Patent: March 4, 2008Assignee: The Penn State Research FoundationInventors: Waldemar Debinski, Neil Christensen, Akiva Mintz
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Patent number: 7183053Abstract: This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification of individuals at risk for, or having, cervical dysplasia, cervical intraepithelial neoplasia, or cervical cancer.Type: GrantFiled: December 24, 2002Date of Patent: February 27, 2007Assignee: The Penn State Research FoundationInventors: Christopher D. Gocke, Neil Christensen
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Publication number: 20060058252Abstract: The invention provides methods and materials related to treating HPV infections (e.g., HPV infections of cutaneous and mucosal epithelial cells) and HPV-associated conditions (e.g., cervical dysplasia, HPV-associated cervical carcinomas, oral mucosal papilloma cancers, laryngeal papilloma cancers).Type: ApplicationFiled: June 26, 2003Publication date: March 16, 2006Inventors: Gary Clawson, Wei-Hua Pan, Diane Thiboutot, Neil Christensen
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Publication number: 20030175770Abstract: This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification of individuals at risk for, or having, cervical dysplasia, cervical intraepithelial neoplasia, or cervical cancer.Type: ApplicationFiled: December 24, 2002Publication date: September 18, 2003Inventors: Christopher D. Gocke, Neil Christensen
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Patent number: 6511805Abstract: This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification of individuals at risk for, or having, cervical dysplasia, cervical intraepithelial neoplasia, or cervical cancer.Type: GrantFiled: August 31, 2000Date of Patent: January 28, 2003Assignee: The Penn State Research FoundationInventors: Christopher D. Gocke, Neil Christensen
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Publication number: 20020182219Abstract: A method for stimulating a immune response against IL-13R&agr;2 in a subject having or at risk for developing a disease having cells expressing IL-13R&agr;2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R&agr;2 in the subject. A composition for stimulating a immune response against IL-13R&agr;2 in a subject having or at risk for developing a disease having cells expressing IL-13R&agr;2 includes an isolated agent that can stimulate immune response against IL-13&agr;2.Type: ApplicationFiled: March 22, 2002Publication date: December 5, 2002Inventors: Waldemar Debinski, Neil Christensen, Akiva Mintz