Abstract: Generating a product layout includes obtaining attributes of a retail location; correlating the attributes of the retail location to information relating to a product in order to determine whether the product is appropriate for the retail location; and if the product is appropriate for the retail location, generating a layout of the product within the retail location relative to like products according to one or more predefined rules.

Abstract: A machine includes a processor and a memory connected to the processor. The memory stores instructions executed by the processor to preserve a second level domain, track requests for subdomains of the second level domain, determine the size of encoded subdomain data and determine the size of response data for subdomain requests. When the ratio of the number of unique subdomains versus the number of subdomain requests is over a first threshold a first satisfied condition is established. It is determined, in response to the first satisfied condition, when the size of the subdomain data exceeds a second threshold and the size of response data exceeds a third threshold to establish a second satisfied condition corresponding to deemed domain name system tunnel activity. It is determined, in response to the first satisfied condition, when the size of the subdomain data exceeds the second threshold to establish a third satisfied condition corresponding to deemed domain name system data exfiltration activity.

Abstract: A machine includes a processor and a memory connected to the processor. The memory stores instructions executed by the processor to identify a resource attack in response to spikes in the number of unique subdomains being queried and spikes in the number of timeouts or delayed responses from a specified name server.

Abstract: A machine includes a processor and a memory connected to the processor. The memory stores instructions executed by the processor to preserve a second level domain, track requests for subdomains of the second level domain, determine the size of encoded subdomain data and determine the size of response data for subdomain requests. When the ratio of the number of unique subdomains versus the number of subdomain requests is over a first threshold a first satisfied condition is established. It is determined, in response to the first satisfied condition, when the size of the subdomain data exceeds a second threshold and the size of response data exceeds a third threshold to establish a second satisfied condition corresponding to deemed domain name system tunnel activity. It is determined, in response to the first satisfied condition, when the size of the subdomain data exceeds the second threshold to establish a third satisfied condition corresponding to deemed domain name system data exfiltration activity.

Abstract: A machine includes a processor and a memory connected to the processor. The memory stores instructions executed by the processor to identify a resource attack in response to spikes in the number of unique subdomains being queried and spikes in the number of timeouts or delayed responses from a specified name server.

Abstract: The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

Abstract: Generating a product layout includes obtaining attributes of a retail location; correlating the attributes of the retail location to information relating to a product in order to determine whether the product is appropriate for the retail location; and if the product is appropriate for the retail location, generating a layout of the product within the retail location relative to like products according to one or more predefined rules.

Abstract: An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR imaging. The assay reagent may contain an artificially high concentration of an NMR active nucleus.

Abstract: The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarisation methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionaly employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

Abstract: Disclosed is a peptide chain containing one or more dye molecules covalently bonded thereto, characterised in that at least one dye molecule is interposed in the amino sequence forming the peptide chain such that there is at least one amino acid covalently linked to and on each side of the said at least one dye molecule. Also disclosed is an assay method employing the dye-labelled compounds of the invention.