Abstract: A method is disclosed for identifying a member of a peptide library that interacts with a target molecule in situ, the method including expressing immobilised nucleic acid molecules to produce the peptide library in a way that each member of the peptide library is immobilised on the nucleic acid molecule from which it was expressed; contacting the immobilised peptide library with the target molecule; and detecting an interaction between at least one member of the peptide library and the target molecule. The method further comprises sequencing the plurality of nucleic acid molecules in situ on the solid support, such that the at least one member of the peptide library that interacts with the target molecule can be immediately identified, at least by the sequence of the nucleic acid molecule from which it was expressed, without requiring additional or secondary analysis or characterising procedures in order to identify the useful members of the library.

Abstract: Catalyst compositions for preparing polyketones comprising(a) a Group VIII metal compound, containing at least one ligand capable of coordinating to the Group VIII metal, and(b) a boron hydrocarbyl compound are disclosed, in particular catalyst compositions wherein the boron hydrocarbyl compound is a Lewis acid of the formula BXYZ where at least one of X, Y and Z is a monovalent hydrocarbyl group. A preferred catalyst composition comprises a palladium complex and B(C.sub.6 F.sub.5).sub.3.

Abstract: A process for preparing polyketones by polymerizing a mixture of carbon monoxide and one or more olefins in the presence of a group VIII metal catalyst which is prepared by reacting together:(a) a source of a group VIII metal, and(b) an amine, phosphine, arsine or stibine, characterized in that the polymerization is carried out in the presence of a hydrocarbyl aluminoxane is disclosed.The group VIII metal is preferably palladium. The aluminoxane can be of the formula [(R.sup.3 R.sup.4 Al).sub.2 O].sub.n " or [R.sup.5 AlO].sub.n ".sub.+2, where n" is 2-40 and R.sup.3, R.sup.4 and R.sup.5 are independently a C.sub.1 -C.sub.20 hydrocarbyl group.

Abstract: Palladium complexes having the general formula Pd(R'CO.sub.2).sub.2 X where R' is C.sub.1 to C.sub.10 alkyl or C.sub.6 to C.sub.10 aryl and X is a chelating ligand of formula (R.sup.2).sub.2 PYP(R.sup.2).sub.2 where the R.sup.2 groups are independently selected from C.sub.1 to C.sub.4 alkyl, phenyl or alkoxy substituted phenyl, and Y is --(CH.sub.2).sub.n -- where n=2 to 4 are provided. The complexes may be prepared by reacting the compounds Pd(R'CO.sub.2).sub.2 and (R.sup.2).sub.2 PYP(R.sup.2).sub.2 together in an aromatic solvent at a temperature of less than 60.degree. C. in amounts such that the molar ratio of the two compounds is in the range 1.2:1 to 1:1.2.

Abstract: A process for preparing terpolymer polyketones comprises reacting at least two olefins with carbon monoxide at elevated temperature and pressure in the presence of a catalyst prepared from (a) a source of palladium, (b) a source of an anion which either does not coordinate with palladium or is less strongly coordinating to palladium than both carbon monoxide and the olefin(s) used and (c) a bisphosphine of formula (R.sup.1).sub.2 P--R--P(R.sup.1).sub.2 wherein R.sup.1 is an optionally polar substituted aromatic hydrocarbyl group and R is a divalent organic bridging group of formula --(CH.sub.2).sub.n --where n=2 to 8 and (d) a 1,4 quinone. The process is characterized by being carried out in a solvent comprising a mixture of an aprotic polar solvent and from 0.0001 to 0.5% by weight water. The particular solvent system used is especially useful for preparing terpolymer polyketones of high molecular weight.