Abstract: An apparatus and method for efficiently providing stability when updated graphics drivers are used in different hardware configurations. A client device includes one or more processors or another type of an integrated circuit that receives a given graphics driver package. When executed by the client device, the operating system stores the components of the authenticated graphics driver package in a protected system folder as part of a staging step. When the client device executes an application, the client device selects between a user mode driver (UMD) of the given graphics driver package and UMDs of the previously staged graphics driver packages. This selection is based on history information collected during past execution of the application. The client device executes the application using installations of the selected UMD and the kernel mode driver (KMD) of the given graphics driver package.

Abstract: Provided herein are vectors comprising a polycistronic expression casstte comprising a polynucleotide that encodes a CD 19 specific chimeric antigen receptor, a polynucleotide that encodes a cytokine, and a polynucleotide that encodes a marker protein, wherein the polynucleotide that encodes the CD 19-specific chimeric antigen receptor and the polynucleotide that encodes the cytokine coding sequence are separated by a polynucleotide sequence that comprises an F2A element, and wherein the polynucleotide sequence that encodes the cytokine and the polynucleotide sequence that encodes the marker protein are separated by a polynucleotide sequence that comprises a T2A element.

Abstract: Provided herein are vectors comprising a polycistronic expression casstte comprising a polynucleotide that encodes a TCR alpha chain, a polynucleotide that encodes a TCR beta chain, and a polynucleotide that encodes a cytokine, wherein the polynucleotides are separated by polynucleotide sequences that comprise 2A elements.

Abstract: A downhole tool interface is connected to a downhole tool at a surface location. The downhole tool interface retrieves downhole information and wirelessly transmits the downhole information to a remote computing device. The downhole tool interface remains connected to the downhole tool during storage and/or transportation. The downhole tool interface collects status information to transmit to a remote computing device, allowing a drilling operator to better understand the conditions during storage and/or transportation.

Abstract: The present invention provides methods of treating glioblastoma by administering an adenoviral vector that conditionally expresses IL-12 via gene switch under control of an oral activator ligand.

Abstract: A computing device for modifying a virtual environment based on a detected sound, the computing device comprising: a microphone; a display configured to display a virtual environment to a user; and a processor; wherein the processor is configured to: receive, via the microphone, audio data of audio in a monitored environment; use the audio data to determine the occurrence of a non-speech target sound in the monitored environment; determine a modification of the virtual environment associated with the non-speech target sound; and control the display to implement the determined modification.

Abstract: A device for modifying audio output based on a detected sound, the device comprising a processor configured to: determine the occurrence of a target sound in a monitored environment during the output of playback audio to a user via an audio output device; determine whether the target sound is included in a user-defined list of permitted sounds, or in a user-defined list of non-permitted sounds; and if the target sound is included in the list of permitted sounds, control the audio output device to perform at least one of: permit the target sound to be heard by the user during output of the playback audio, and notify the user that the target sound has been recognized; or if the target sound is included in the list of non-permitted sounds, control the audio output device to prevent the target sound being heard by the user during output of the playback audio.

Abstract: A downhole tool interface is connected to a downhole tool at a surface location. The downhole tool interface retrieves downhole information and wirelessly transmits the downhole information to a remote computing device. The downhole tool interface remains connected to the downhole tool during storage and/or transportation. The downhole tool interface collects status information to transmit to a remote computing device, allowing a drilling operator to better understand the conditions during storage and/or transportation.

Abstract: A computing device comprising a processor, the processor configured to: receive, from an image capture system, an image captured in an environment and image metadata associated with the image, the image metadata comprising an image capture time; receive a sound recognition message from a sound recognition module, the sound recognition message comprising (i) a sound recognition identifier indicating a target sound or scene that has been recognised based on captured audio data captured in the environment, and (ii) time information associated with the sound recognition identifier; detect that the target sound or scene occurred at a time that the image was captured based on the image metadata and the time information in the sound recognition message; and output a camera control command to said image capture system based on said detection.

Abstract: Verification of presence of a detected target is carried out following an initial presence determination on the basis of detected non-verbal sound.

Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for “off-the-shelf” treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negative T cells are generated using zinc finger nucleases, for example.

Abstract: Control of navigation of a content item is carried out by detection of non-verbal sound events. On the basis of receipt of one or more non-verbal sound event reports, a navigation tool is provided with a corresponding sequence of navigation commands. The correspondence between navigation command sequences and non-verbal sound events is established through analysis or markup of the content item.

Abstract: A device or system is provided which is configured to detect one or more sound events and/or scenes associated with a predetermined context, and to provide an assistive output on fulfilment of that context.

Abstract: A computing device, the computing device comprising: a location data processing module configured to receive location data from a location sensor of the computing device and output location information; a sound data processing module configured to receive audio data from a microphone of the computing device and output audio information relating to one or more non-verbal sounds of an environment of the computing device captured by the microphone; and an augmentation module configured to: receive the location information and the audio information; generate augmented location data, the augmented location data comprising the location information and the audio information; and output the augmented location data for storage in a data store.

Abstract: A computing device comprising a processor, the processor configured to: receive, from an image capture system, an image captured in an environment and image metadata associated with the image, the image metadata comprising an image capture time; receive a sound recognition message from a sound recognition module, the sound recognition message comprising (i) a sound recognition identifier indicating a target sound or scene that has been recognised based on captured audio data captured in the environment, and (ii) time information associated with the sound recognition identifier; detect that the target sound or scene occurred at a time that the image was captured based on the image metadata and the time information in the sound recognition message; and output a camera control command to said image capture system based on said detection.

Abstract: A computing device, the computing device comprising a processor configured to: receive audio information relating to one or more non-verbal sounds captured by a microphone in an environment of a user; receive motion information that is based on motion sensor data captured by a motion sensor, said motion information relating to motion of said user in the environment; process the audio information and the motion information to recognise an activity of said user; and output an activity recognition notification indicating said activity.

Abstract: A device or system is provided which is configured to detect one or more sound events and/or scenes associa ted with a predetermined context, and to provide an assistive output on fulfilment of that context.

Abstract: Sound detection and identification leads to responsiveness within an augmented reality environment. Information about an identified sound can be converted into a command for implementation by an augmented reality system, for display of a desired on-screen augmented reality effect.

Abstract: A camlock is for use in a flange assembly. The camlock comprises: a cam member for engaging a flange, the cam member arranged to be rotatable about its rotational axis; and a ratchet mechanism including first and second ratchet members, the first and second ratchet members arranged in a mutual engagement to permit relative movement between the first and second ratchet members in one direction and limit relative movement between the first and second ratchet members in the opposite direction, wherein the cam member and the ratchet mechanism are arranged so that the mutual engagement between the first and second ratchet members-permits rotation of the cam member about its rotational axis in one direction and limits rotation of the cam member about its rotational axis in the opposite direction.

Abstract: Control of navigation of a content item is carried out by detection of non-verbal sound events. On the basis of receipt of one or more non-verbal sound event reports, a navigation tool is provided with a corresponding sequence of navigation commands. The correspondence between navigation command sequences and non-verbal sound events is established through analysis or markup of the content item.