Abstract: The present invention relates to a method for determining one or more intrinsic properties of a DNA component from a plurality of measurements obtained over a time period from a cell culture, with each cell comprising the DNA component, wherein the DNA component is involved in transcription of one or more target signals, wherein the plurality of measurements comprises measurements relating to the density of the cell culture over the time period and measurements relating to the amount of the one or more target signals in the cell culture over the time period.

Abstract: The present invention relates to a method for determining one or more intrinsic properties of a DNA component from a plurality of measurements obtained over a time period from a cell culture, with each cell comprising the DNA component, wherein the DNA component is involved in transcription of one or more target signals, wherein the plurality of measurements comprises measurements relating to the density of the cell culture over the time period and measurements relating to the amount of the one or more target signals in the cell culture over the time period.

Abstract: A computer-implemented method comprising: from each of multiple trials, obtaining a respective series of observations y(t) of a subject over time t; using a variational auto encoder to model an ordinary differential equation, ODE, wherein the variational auto encoder comprises an encoder for encoding the observations into a latent vector z and a decoder for decoding the latent vector, the encoder comprising a first neural network and the decoder comprising one or more second neural networks, wherein the ODE as modelled by the decoder has a state x(t) representing one or more physical properties of the subject which result in the observations y, and the decoder models a rate of change of x with respect to time t as a function f of at least x and z: dx/dt=f(x, z); and operating the variational auto encoder to learn the function f based on the obtained observations y.

Abstract: A computer-implemented method comprising: from each of multiple trials, obtaining a respective series of observations y(t) of a subject over time t; using a variational auto encoder to model an ordinary differential equation, ODE, wherein the variational auto encoder comprises an encoder for encoding the observations into a latent vector z and a decoder for decoding the latent vector, the encoder comprising a first neural network and the decoder comprising one or more second neural networks, wherein the ODE as modelled by the decoder has a state x(t) representing one or more physical properties of the subject which result in the observations y, and the decoder models a rate of change of x with respect to time t as a function f of at least x and z: dx/dt=f(x, z); and operating the variational auto encoder to learn the function f based on the obtained observations y.

Abstract: The present invention relates to a method for determining one or more intrinsic properties of a DNA component from a plurality of measurements obtained over a time period from a cell culture, with each cell comprising the DNA component, wherein the DNA component is involved in transcription of one or more target signals, wherein the plurality of measurements comprises measurements relating to the density of the cell culture over the time period and measurements relating to the amount of the one or more target signals in the cell culture over the time period.