Patents by Inventor Neil DALTON
Neil DALTON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170115310Abstract: Methods of predicting rapid decline in renal function in diabetes employing panels of biomarkers. The methods are useful for predicting risk of decline of renal function in individual subject and also for selecting subjects for clinical trials.Type: ApplicationFiled: March 18, 2015Publication date: April 27, 2017Inventors: Helen COLHOUN, Helen LOOKER, Paul MCKEIGUE, Marco COLUMBO, David DUNGER, Neil DALTON, Mary Julia BROSNAN, Everson NOGOCEKE, Felix AGAKOV, Sibylle HESS
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Patent number: 9347084Abstract: A method for screening for variant peptides uses mass spectrometry (MS). A system and a kit may be used for performing the method. Proteins in a sample are digested to form a defined series of peptides. The defined series of peptides are ionized. The ionized species are subjected to collision induced dissociation. Species of known mass/charge ratio are detected to confirm the presence of the protein variant in the original sample.Type: GrantFiled: February 24, 2014Date of Patent: May 24, 2016Assignees: King's College London, Guy's St. Thomas' NHS Foundation TrustInventors: Charles Turner, Raymond Neil Dalton, Yvonne Anne Daniel
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Publication number: 20140212906Abstract: A method for screening for variant peptides uses mass spectrometry (MS). A system and a kit may be used for performing the method. Proteins in a sample are digested to form a defined series of peptides. The defined series of peptides are ionized. The ionized species are subjected to collision induced dissociation. Species of known mass/charge ratio are detected to confirm the presence of the protein variant in the original sample.Type: ApplicationFiled: February 24, 2014Publication date: July 31, 2014Applicants: Guy's & St. Thomas' NHS Foundation Trust, King's College LondonInventors: Charles Turner, Raymond Neil Dalton, Yvonne Anne Daniel
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Patent number: 8658396Abstract: A method for screening for variant peptides uses mass spectrometry (MS). A system and a kit may be used for performing the method. Proteins in a sample are digested to form a defined series of peptides. The defined series of peptides are ionized. The ionized species are subjected to collision induced dissociation. Species of known mass/charge ratio are detected to confirm the presence of the protein variant in the original sample.Type: GrantFiled: February 1, 2006Date of Patent: February 25, 2014Assignee: King's College LondonInventors: Charles Turner, Raymond Neil Dalton, Yvonne Anne Daniel
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Patent number: 8628936Abstract: The invention relates to a method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: the structural composition of a polypeptide comprised by said sample; a metabolite comprised by said sample; and a catalytic activity comprised by said sample, wherein each of said at least two characteristics is determined from a multiplexed analysis of the same sample. The invention also relates to certain compositions.Type: GrantFiled: December 5, 2008Date of Patent: January 14, 2014Assignees: King's College London, Guy's and St. Thomas' NHS Foundation TrustInventors: Charles Turner, Raymond Neil Dalton
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Patent number: 8361740Abstract: The invention relates to methods for making a peptide standard for mass spectrometry said method comprising (a) identifying endopeptidase cleavage sites in a parent polypeptide sequence of interest; (b) selecting peptide sequences from said parent polypeptide which are defined by endopeptidase cleavage sites of step (a); (c) adding a C-terminal extension to each selected sequence; wherein if the endopeptidase cleavage site is C-terminal to its recognition sequence then the C-terminal extension comprises 1 to 6 amino acids, wherein if the endopeptidase cleavage site is N-terminal to its recognition sequence then the C-terminal extension comprises said recognition sequence, wherein if the endopeptidase cleavage site is within its recognition sequence then the C-terminal extension comprises the remainder of said recognition sequence C-terminal to the cleavage site; and (d) synthesizing a peptide having the extended amino acid sequence of step (c).Type: GrantFiled: May 2, 2008Date of Patent: January 29, 2013Assignees: King's College London, Guy's and St. Thomas' NHS Foundation TrustInventors: Charles Turner, Raymond Neil Dalton
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Publication number: 20100273199Abstract: The invention relates to a method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: the structural composition of a polypeptide comprised by said sample; a metabolite comprised by said sample; and a catalytic activity comprised by said sample, wherein each of said at least two characteristics is determined from a multiplexed analysis of the same sample. The invention also relates to certain compositions.Type: ApplicationFiled: December 5, 2008Publication date: October 28, 2010Applicants: KING'S COLLEGE LONDON, GUY'S AND ST. THOMAS' NHS FOUNDATION TRUSTInventors: Charles Turner, Raymond Neil Dalton
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Publication number: 20100159473Abstract: The invention relates to methods for making a peptide standard for mass spectrometry said method comprising (a) identifying endopeptidase cleavage sites in a parent polypeptide sequence of interest; (b) selecting peptide sequences from said parent polypeptide which are defined by endopeptidase cleavage sites of step (a); (c) adding a C-terminal extension to each selected sequence; wherein if the endopeptidase cleavage site is C-terminal to its recognition sequence then the C-terminal extension comprises 1 to 6 amino acids, wherein if the endopeptidase cleavage site is N-terminal to its recognition sequence then the C-terminal extension comprises said recognition sequence, wherein if the endopeptidase cleavage site is within its recognition sequence then the C-terminal extension comprises the remainder of said recognition sequence C-terminal to the cleavage site; and (d) synthesising a peptide having the extended amino acid sequence of step (c).Type: ApplicationFiled: May 2, 2008Publication date: June 24, 2010Applicants: KING'S COLLEGE LONDON, GUY'S AND ST. THOMAS' NHS FOUNDATION TRUSTInventors: Charles Turner, Raymond Neil Dalton
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Publication number: 20080280345Abstract: The present invention relates to a method for screening for variant peptides using mass spectrometry (MS). The present invention also relates to a system and a kit for performing the method.Type: ApplicationFiled: February 1, 2006Publication date: November 13, 2008Applicants: King's College London, Guy's & St. Thomas' NHS Foundation TrustInventors: Charles Turner, Raymond Neil Dalton, Yvonne Anne Daniel