Abstract: The present invention relates to compounds of Formula I as defined herein, and salts and solvates thereof. (I) The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to compounds of Formula (I) for use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which inhibition of a RAS-effector protein-protein interaction is implicated.

Abstract: A system and method is provided for assessing similarity between audio files, such as music files. The system converts test audio files and training audio files from a first format to a second format that includes audio metric identifiers. The system further generates training a graph database and a test graph database using associations between a first set of converted training or test files and a second set of training or test files. The training graph database is used to train a neural network. The neural network generates a set of associations between the first and second sets of the test audio files as part of creating a neural graph database. The system compares the test graph database to the neural graph database to assess a similarity that is used to update the neural network.

Abstract: The present invention relates to compounds of Formula I as defined herein, and salts and solvates thereof. (I) The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to compounds of Formula (I) for use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which inhibition of a RAS-effector protein-protein interaction is implicated.

Abstract: A magnetic self-latching device for a gate has a main body with handles on either side for operation or has an arrangement to be remotely actuated. A latching body has a high strength magnet usually provided at the bottom of a cavity which defines a latching shoulder. The latching body is adapted to be fixed to a gate post. The main body, with its housing, can be mounted on the gate frame and incorporates a latch pin which, in the door-closed position, is displaced by magnetic attraction to an extended latching position and against the biasing of a return spring. The gate cannot be opened until actuation of the mechanism occurs, for example by rotating a handle to retract the pin against the magnetic force; the gate can then be swung open. When the handle is released, the biasing spring retains the latch pin in a retracted position.

Abstract: A self-latching device is disclosed which is arranged to latch, in a predetermined position, two members which are otherwise movable relative to each other such as a hinged gate. The device comprises a latch arm having a latch element and a manual actuator mounted on one of the members and which is movable between a latched and a retracted position, by upward manual displacement of the actuator, and a retaining element incorporating a permanent magnet mounted on the other member. The latch arm is spring biased into the retracted position but, when in the predetermined position, is caused to move by the magnetic field generated by the magnetic into the latched position wherein any substantial relative movement of the two members is prevented by the latch arm engaging the retaining element.

Abstract: The present invention relates to engagemnent devices and coupling members for forming a structural frame work for hollow tubes. One form of engagement device comprises a hollow sleeve (1) through which a tube (31) may be passed. The hollow sleeve has a deformable flared portion (2). A further hollow sleeve member (12) is immovable on the outside of the first sleeve and has a surface (13) arranged to co-operate the flared portion to cause it to deform to grip the tube (31). A further engagement device comprises a hollow sleeve portion (100) which is distendable to grip a tube mounted on its surface. A trustoconical wedge (101) is movable within the hollow sleeve potion (100) to cause to distend. A number of engagement devices may be connected together to form coupling members for connecting tubes to form a structural frame work.

Abstract: The hinge comprises a first hinge member (11) and a second hinge member (12). The first hinge member comprises a cylindrical housing (16) having first and second open ends (17 and 18 respectively). The cylindrical housing (16) is located between flange members (26 and 27) of the second hinge member (12). A torsion spring (20) is provided inside the cylindrical housing (16) and one end (21) fits into a recess (22) at end (18) of the cylindrical housing (16) and the other end fits into a recess (36) in a coupling element (30) which is located at the other end (17) of the cylindrical housing (16). The coupling element (30) has a hexagonal engagement surface (39) which engages a matching engagement surface in flange (27).

Abstract: A self latching device is disclosed which is arranged to latch in a predetermined position, two members which are otherwise movable relative to each other. The device comprises a latch arm arranged to be mounted to one of the members and which is movable between a latched and a retracted position , and a retaining element incorporating a permanent magnet arranged to be mounted to the other member. The latch arm is spring biased into the retracted position but, when in the predetermined position, is caused to move by the magnetic field generated by the magnet into the latched position wherein any substantial relative movement of the two members is prevented by the latch arm engaging the retaining element.