Patents by Inventor Neil E. Jaffe

Neil E. Jaffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF ALKALINE WASHES DURING CHROMATOGRAPHY TO REMOVE IMPURITIES
    Publication number: 20200282332
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 10, 2020
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel
  • Use of alkaline washes during chromatography to remove impurities
    Patent number: 10695693
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, said method comprising: a) subjecting the mixture to a first chromatography matrix, wherein the protein of interest binds to the first chromatography matrix; b) contacting the first chromatography matrix with a first wash solution which has a pH of at least 9.0, and does not comprise arginine or an arginine derivative; and c) eluting the protein of interest from the first chromatography matrix into an elution solution.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: June 30, 2020
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel
  • USE OF ALKALINE WASHES DURING CHROMATOGRAPHY TO REMOVE IMPURITIES
    Publication number: 20180078876
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, said method comprising: a) subjecting the mixture to a first chromatography matrix, wherein the protein of interest binds to the first chromatography matrix; b) contacting the first chromatography matrix with a first wash solution which has a pH of at least 9.0, and does not comprise arginine or an arginine derivative; and c) eluting the protein of interest from the first chromatography matrix into an elution solution.
    Type: Application
    Filed: March 11, 2016
    Publication date: March 22, 2018
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel