Patents by Inventor Neil F. Duffy, Jr.
Neil F. Duffy, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240123449Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container.Type: ApplicationFiled: May 18, 2023Publication date: April 18, 2024Inventors: Andy H. Levine, John C. Meade, Neil Tischler, Jeffrey R. Chabot, Andrew McGillicuddy, Neil F. Duffy, JR.
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Patent number: 11660603Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a syringe and a syringe holder, the syringe having a proximal top with a luer port, a sidewall extending from the top forming a syringe tube, and a plunger slidably disposed inside the syringe tube, the plunger forming a sealing engagement with the sidewall, the syringe holder defining a cavity for receiving the syringe, wherein a distal end of the syringe tube is at least partially closed by the syringe holder after the plunger is placed inside the syringe tube.Type: GrantFiled: April 7, 2022Date of Patent: May 30, 2023Assignee: Cervos Medical LLCInventors: Andy H. Levine, John Meade, Neil S. Tischler, Jeffrey R. Chabot, Andrew McGillicuddy, Neil F. Duffy, Jr.
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Publication number: 20230072916Abstract: A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.Type: ApplicationFiled: October 25, 2022Publication date: March 9, 2023Inventors: Andrew McGillicuddy, Andy H. Levine, Neil F. Duffy, Jr.
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Patent number: 11497480Abstract: A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.Type: GrantFiled: February 15, 2019Date of Patent: November 15, 2022Assignee: Cervos Medical LLCInventors: Andrew McGillicuddy, Andy H. Levine, Neil F. Duffy, Jr.
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Publication number: 20220257220Abstract: A bone marrow aspiration device includes an outer cannula connected to an outer handle, and a first cannula that fits through the outer cannula and extends beyond a distal end of the outer cannula. The first cannula is connected to a first handle including a mating feature. A removable sharp stylet fits coaxially through the first cannula and is connected to a stylet handle including a mating feature to engage with the mating feature of the first handle, to couple the stylet handle to the first handle. A proximal end of stylet forms an adapter to couple to a drill, the first cannula and stylet rotating together when driven by the drill coupled to the adapter. A second cannula fits through the first cannula once the stylet is removed, a distal end of the second cannula closing off the distal end of the first cannula but leaving open one or more side apertures in the first cannula, to aspirate bone marrow through the open side apertures.Type: ApplicationFiled: February 11, 2022Publication date: August 18, 2022Inventors: Andrew McGillicuddy, Neil F. Duffy, JR.
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Publication number: 20220226812Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container.Type: ApplicationFiled: April 7, 2022Publication date: July 21, 2022Inventors: Andy H. Levine, John C. Meade, Neil Tischler, Jeffrey R. Chabot, Andrew McGillicuddy, Neil F. Duffy, JR.
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Publication number: 20200324285Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container.Type: ApplicationFiled: March 30, 2020Publication date: October 15, 2020Inventors: Andy H. Levine, John Meade, Neil S. Tischler, Jeffrey R. Chabot, Andrew McGillicuddy, Neil F. Duffy, JR.
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Patent number: 10603665Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container.Type: GrantFiled: January 29, 2014Date of Patent: March 31, 2020Assignee: EndoCellutions, Inc.Inventors: Andy H. Levine, John C. Meade, Neil Tischler, Jeffrey R. Chabot, Andrew McGillicuddy, Neil F. Duffy, Jr.
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Publication number: 20190314004Abstract: A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.Type: ApplicationFiled: February 15, 2019Publication date: October 17, 2019Inventors: Andrew McGillicuddy, Andy H. Levine, Neil F. Duffy, JR.
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Patent number: 10231716Abstract: A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.Type: GrantFiled: October 29, 2013Date of Patent: March 19, 2019Assignee: EndoCellutions, Inc.Inventors: Andrew McGillicuddy, Andy H. Levine, Neil F. Duffy, Jr.
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Patent number: 9763877Abstract: The anatomic and functional arrangement of the gastrointestinal tract suggests an important function of this organ is its ability to regulate the trafficking of metabolites as well as control the equilibrium between tolerance and immunity through gut-associated lymphoid tissue, the neuroendocrine network, and the intestinal epithelial barrier. Combining nucleated cells from various tissues and introducing them directly into the small intestine will have a positive effect on diabetes.Type: GrantFiled: August 10, 2015Date of Patent: September 19, 2017Assignee: EndoCellutions, Inc.Inventors: Neil F. Duffy, Jr., Andrew McGillicuddy
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Publication number: 20160101047Abstract: The anatomic and functional arrangement of the gastrointestinal tract suggests an important function of this organ is its ability to regulate the trafficking of metabolites as well as control the equilibrium between tolerance and immunity through gut-associated lymphoid tissue, the neuroendocrine network, and the intestinal epithelial barrier. Combining nucleated cells from various tissues and introducing them directly into the small intestine will have a positive effect on diabetes.Type: ApplicationFiled: August 10, 2015Publication date: April 14, 2016Inventors: Neil F. Duffy, JR., Andrew McGillicuddy
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Publication number: 20160008808Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container.Type: ApplicationFiled: January 29, 2014Publication date: January 14, 2016Inventors: Andy H. Levine, John C. Meade, Neil Tischler, Jeffrey R. Chabot, Andrew McGillicuddy, Neil F. Duffy, JR.
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Publication number: 20150289858Abstract: A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.Type: ApplicationFiled: October 29, 2013Publication date: October 15, 2015Inventors: Andrew McGillicuddy, Andy H. Levine, Neil F. Duffy, Jr.
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Patent number: 9101570Abstract: The anatomic and functional arrangement of the gastrointestinal tract suggests an important function of this organ is its ability to regulate the trafficking of metabolites as well as control the equilibrium between tolerance and immunity through gut-associated lymphoid tissue, the neuroendocrine network, and the intestinal epithelial barrier. Combining nucleated cells from various tissues and introducing them directly into the small intestine will have a positive effect on diabetes.Type: GrantFiled: February 1, 2010Date of Patent: August 11, 2015Assignee: EndoCellutions, Inc.Inventors: Neil F. Duffy, Jr., Andrew McGillicuddy
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Patent number: 8241592Abstract: Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample. A sample holder for isolating a fraction of interest from a physiological fluid sample includes a flexible compartment and a rigid exoskeleton that supports the flexible compartment. The flexible compartment may have at least one reservoir with a height to volume ratio of about 0.1 cm/mL to about 5 cm/mL. An automated device for extracting a fraction of interest from the sample includes a sample holder with a flexible compartment supported by a rigid exoskeleton, a support for the sample holder connected to one or more fluid extraction devices, and a motor for moving the extraction device relative to the sample holder. The automated device may include an optical sensor and may include a clamp for clamping the flexible compartment.Type: GrantFiled: September 29, 2011Date of Patent: August 14, 2012Assignee: Endocellutions, Inc.Inventors: Neil F. Duffy, Jr., Jeffrey R. Chabot, Edward H. Kislauskis
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Publication number: 20120021501Abstract: Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample. A sample holder for isolating a fraction of interest from a physiological fluid sample includes a flexible compartment and a rigid exoskeleton that supports the flexible compartment. The flexible compartment may have at least one reservoir with a height to volume ratio of about 0.1 cm/mL to about 5 cm/mL. An automated device for extracting a fraction of interest from the sample includes a sample holder with a flexible compartment supported by a rigid exoskeleton, a support for the sample holder connected to one or more fluid extraction devices, and a motor for moving the extraction device relative to the sample holder. The automated device may include an optical sensor and may include a clamp for clamping the flexible compartment.Type: ApplicationFiled: September 29, 2011Publication date: January 26, 2012Applicant: ECW Therapeutics, Inc.Inventors: Neil F. Duffy, JR., Jeffrey R. Chabot, Edward H. Kislauskis
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Patent number: 8048678Abstract: Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample. A sample holder for isolating a fraction of interest from a physiological fluid sample includes a flexible compartment and a rigid exoskeleton that supports the flexible compartment. The flexible compartment may have at least one reservoir with a height to volume ratio of about 0.1 cm/mL to about 5 cm/mL. An automated device for extracting a fraction of interest from the sample includes a sample holder with a flexible compartment supported by a rigid exoskeleton, a support for the sample holder connected to one or more fluid extraction devices, and a motor for moving the extraction device relative to the sample holder. The automated device may include an optical sensor and may include a clamp for clamping the flexible compartment.Type: GrantFiled: June 29, 2010Date of Patent: November 1, 2011Assignee: ECW Therapeutics, Inc.Inventors: Neil F. Duffy, Jr., Jeffrey R. Chabot, Edward H Kislauskis
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Publication number: 20110033925Abstract: Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample.Type: ApplicationFiled: June 29, 2010Publication date: February 10, 2011Inventors: Neil F. Duffy, JR., Jeffrey R. Chabot, Edward H. Kislauskis