Abstract: Aspects of the disclosure provided herein relate to compositions and methods for providing a drug delivery through a transdermal patch. Some other embodiments relate to a transdermal drug delivery patch comprising a bottom layer comprising a skin side liner, a middle layer comprising a gel, a top layer comprising a release liner, wherein the adhesive or gel comprises at least one drug capable of modulating histamine in a subject. Some other embodiments provided herein relate to a transdermal drug delivery system for delivery of at least one drug into a tissue membrane of a subject. Some other embodiments relate to a transdermal drug delivery patch comprising a bottom layer comprising a skin side liner, a middle layer comprising a gel/adhesive, a top layer comprising a release liner, wherein the gel comprises at least one drug capable of modulating histamine receptors in a subject.

Abstract: The following contains a method and package for reducing pain medication taken by a patient.

Abstract: The present invention provides an improved package from the administration of active ingredients. The present invention provides a package comprising: a standard portion comprising one or more active ingredients in a plurality of different potencies, and a rescue portion comprising one or more same or different active ingredients. The package may be optionally be used with a patient assessment module. The present invention also provides a kit comprising: a package comprising a standard portion comprising one or more active ingredients in a plurality of different potencies, and a patient assessment module comprising instructions for administration of the standard portion. The package may optionally further comprise a rescue portion.