Patents by Inventor Neil Frankish

Neil Frankish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9586885
    Abstract: Described are compounds of the structural formula (I): Also provided are pharmacologically acceptable isomers and salts of the compound of (I). The compounds are useful in the treatment of inflammatory bowel disease.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: March 7, 2017
    Assignee: Venantius Limited
    Inventors: Neil Frankish, Helen Sheridan
  • Patent number: 9260376
    Abstract: Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the formula: wherein R is selected from one or more of the same or different of hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted aryl, alkoxy, aryloxy, thiol, and optionally substituted amino, and wherein R1 is selected from one or more of the same or different of hydrogen, acetyl, optionally substituted alkyl, optionally substituted aryl, and an amino acid selected from leucine, valine, isoleucine, and glycine.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 16, 2016
    Assignee: VENANTIUS LIMITED
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20150141506
    Abstract: Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the absolute stereochemistry and formula: In some cases R1 is leucine and R is selected from: OH, OCH3, OCH2CH3, OCH2CH2CH3, NH2, NHCH2CH2OH, NHCH3, N(CH3)2, NH(4-OH-3-benzoic acid).
    Type: Application
    Filed: May 23, 2013
    Publication date: May 21, 2015
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20150141523
    Abstract: A compound of the absolute stereochemical formula and salts thereof is useful in the prophylaxis or treatment of inflammatory bowel disease or other inflammatory autoimmune diseases with similar aetiology involving T-cell proliferation or or function.
    Type: Application
    Filed: May 23, 2013
    Publication date: May 21, 2015
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20140128466
    Abstract: Described are compounds of the structural formula (I): Also provided are pharmacologically acceptable isomers and salts of the compound of (I). The compounds are useful in the treatment of inflammatory bowel disease.
    Type: Application
    Filed: July 20, 2012
    Publication date: May 8, 2014
    Applicant: VENANTIUS LIMITED
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20140107194
    Abstract: Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the formula: wherein R is selected from one or more of the same or different of hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted aryl, alkoxy, aryloxy, thiol, and optionally substituted amino, and wherein R1 is selected from one or more of the same or different of hydrogen, acetyl, optionally substituted alkyl, optionally substituted aryl, and an amino acid selected from leucine, valine, isoleucine, and glycine.
    Type: Application
    Filed: July 20, 2012
    Publication date: April 17, 2014
    Applicant: Venantius Limited
    Inventors: Neil Frankish, Helen Sheridan
  • Patent number: 6433021
    Abstract: Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: August 13, 2002
    Assignee: Venantius Limited
    Inventors: Neil Frankish, Helen Sheridan, John Walsh, Michael Jordan
  • Patent number: 6423752
    Abstract: Indane dimer compounds of general formula 5 or 6 are pharmaceutically useful, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or inflammatory activity. In formula 5 R1, R2 and R3to R15 and in formula 6 R1, R2 and R4 to R15, are selected from one or more of the same of different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, sulphonic acid groups, sulphoxide groups, sulphone groups, C1-C10 alkyl or C3-C8 cycloalkyl groups. In formulae 5 and 6, X is O or NR, and the R in NR may be hydrogen, acyl, alkyl or sulphonate groups. In formulae 5 and 6 any one or more of R1, 1R1; R1, 1R2; R9, 1R9; R10, 1R10 and R14, 1R10 may together represent oxo.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: July 23, 2002
    Assignee: Venantius Limited
    Inventors: John Walsh, Neil Frankish, Helen Sheridan, William Byrne
  • Publication number: 20020052530
    Abstract: Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R1 and R3 to R15, and in formula 6, R1, R2 and R4 to R15, are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oximc, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 ca
    Type: Application
    Filed: June 8, 1998
    Publication date: May 2, 2002
    Inventors: JOHN WALSH, NEIL FRANKISH, HELEN SHERIDAN, WILLIAM BYRNE
  • Patent number: 6300376
    Abstract: Indane dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity are described.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: October 9, 2001
    Assignee: Venantius Limited
    Inventors: John Walsh, Neil Frankish, Helen Sheridan, Ronan Farrell, William Byrne
  • Patent number: 6297399
    Abstract: Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 to R13, in formula (8) R1 and R3 and R13 are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing heretro atoms containing one or more of N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may s
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: October 2, 2001
    Assignee: Venantius Limited
    Inventors: John Walsh, Neil Frankish, Helen Sheridan, William Byrne