Patents by Inventor Neil Fred Langille

Neil Fred Langille has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 11958809
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: April 16, 2024
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven M. Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20240101517
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: November 27, 2023
    Publication date: March 28, 2024
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI (DECEASED)
  • Synthesis of Sulfonamide Intermediates
    Publication number: 20230357137
    Abstract: Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
    Type: Application
    Filed: April 28, 2021
    Publication date: November 9, 2023
    Applicant: AMGEN INC.
    Inventors: Neil Fred LANGILLE, Jason S. TEDROW, Jonathan Vinh-Phu TRUONG, Robert Ronald MILBURN, Alessandro ARENA
  • Synthesis of Vinyl Cyclobutyl Intermediates
    Publication number: 20230183164
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
    Type: Application
    Filed: May 4, 2021
    Publication date: June 15, 2023
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Michael T. CORBETT, Neil Fred LANGILLE, Kyle D. BAUCOM, Peter K. DORNAN, Gabrielle ST- PIERRE, Philipp C. ROOSEN, Sheng CUI, Roberto PROFETA
  • METHYLATION OF MCL-1 COMPOUNDS
    Publication number: 20230117777
    Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).
    Type: Application
    Filed: March 30, 2021
    Publication date: April 20, 2023
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, Sheng CUI, Tsang-Lin HWANG, Neil Fred LANGILLE, Janine K. TOM, James E. HUCKLE, Markian STEC, Tian WU, Sean P. BROWN
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20230044617
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: September 8, 2022
    Publication date: February 9, 2023
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI
  • PROCESS FOR SYNTHESIZING APREMILAST
    Publication number: 20220348542
    Abstract: Provided herein are processes for synthesizing apremilast comprising reacting 3-acetamidophthalic anhydride and (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine or a salt thereof to form apremilast. Also provided are processes for isolating apremilast from the reaction mixture, as described herein.
    Type: Application
    Filed: April 25, 2022
    Publication date: November 3, 2022
    Inventors: Matthew G. Beaver, Carolyn Cohen, Neil Fred Langille, Simone Spada
  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 11472773
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: October 18, 2022
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20220153700
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: September 24, 2021
    Publication date: May 19, 2022
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven M. MENNEN, Jacqueline C.S WOO, Bradley Paul MORGAN, Alex MUCI
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20200399221
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: July 2, 2020
    Publication date: December 24, 2020
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20200331859
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: July 2, 2020
    Publication date: October 22, 2020
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20200079736
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 12, 2020
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20180312469
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: April 26, 2018
    Publication date: November 1, 2018
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline Woo, Bradley Paul Morgan, Alex Muci
  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 9988354
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 5, 2018
    Assignee: AMGEN INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline Woo
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20160016906
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Applicants: AMGEN INC., CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline Woo, Bradley Paul Morgan, Alex Muci