Patents by Inventor Neil G. Almstead

Neil G. Almstead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-YL]-benzoic acid
    Patent number: 7863456
    Abstract: The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: January 4, 2011
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon
  • Use of Acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease
    Patent number: 7763656
    Abstract: Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: July 27, 2010
    Assignees: PTC Therapeutics, Inc., Amgen Inc.
    Inventors: Richard G. Wilde, Ellen M. Welch, James Jan Takasugi, Neil G. Almstead, Steven Marc Rubenstein, Holger Beckmann
  • Processes for the preparation of 1,2,4-oxadiazole benzoic acids
    Patent number: 7678922
    Abstract: Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: March 16, 2010
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Seemon Pines, Young-Choon Moon, James J. Takasugi
  • PROCESSES FOR THE PREPARATION OF 1,2,4-OXADIAZOLE BENZOIC ACIDS
    Publication number: 20100063297
    Abstract: Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 11, 2010
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Seemon Pines, Young-Choon Moon, James J. Takasugi
  • Compounds for Nonsense Suppression, and Methods for Their Use
    Publication number: 20090253699
    Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
    Type: Application
    Filed: October 13, 2005
    Publication date: October 8, 2009
    Applicant: PCT Therapeutics, Inc.
    Inventors: Neil G. Almstead, Guangming Chen, Gary M. Karp, Ellen Welch, Richard Wilde, Jeffrey A. Campbell
  • Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
    Patent number: 7449570
    Abstract: The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: November 11, 2008
    Assignees: PTC Therapeutics, Inc., Amgen Inc.
    Inventors: Richard G. Wilde, Neil G. Almstead, Ellen M. Welch, Holger Beckmann
  • Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-YL]-benzoic acid
    Publication number: 20080171377
    Abstract: The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
    Type: Application
    Filed: September 24, 2007
    Publication date: July 17, 2008
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon
  • Processes for the preparation of 1,2,4-oxadiazole benzoic acids
    Publication number: 20080139818
    Abstract: Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
    Type: Application
    Filed: September 6, 2007
    Publication date: June 12, 2008
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Seemon Pines, Young-Choon Moon, James J. Takasugi
  • Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression
    Publication number: 20080139632
    Abstract: Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Application
    Filed: September 24, 2007
    Publication date: June 12, 2008
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon, Ellen M. Welch
  • Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
    Patent number: 7291603
    Abstract: The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: November 6, 2007
    Assignee: PTC Therapeutics, Inc.
    Inventors: Richard G. Wilde, Paul D. Kennedy, Neil G. Almstead, Ellen M. Welch, James J. Takasugi, Westley J. Friesen
  • Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
    Patent number: 7247741
    Abstract: Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: July 24, 2007
    Assignees: PTC Therapeutics, Inc., Amgen Inc.
    Inventors: Richard G. Wilde, Ellen M. Welch, James Jan Takasugi, Neil G. Almstead, Steven Marc Rubenstein, Holger Beckmann
  • Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
    Publication number: 20040067900
    Abstract: The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
    Type: Application
    Filed: July 22, 2003
    Publication date: April 8, 2004
    Inventors: Richard G. Wilde, Paul D. Kennedy, Neil G. Almstead, Ellen M. Welch, James J. Takasugi, Westley J. Friesen