Abstract: Data reuse cache techniques are described. In one example, a load instruction is generated by an execution unit of a processor unit. In response to the load instruction, data is loaded by a load-store unit for processing by the execution unit and is also stored to a data reuse cache communicatively coupled between the load-store unit and the execution unit. Upon receipt of a subsequent load instruction for the data from the execution unit, the data is loaded from the data reuse cache for processing by the execution unit.

Abstract: Provided herein are compounds of Formula I and their salts, and compositions thereof that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) and/or acetylcholinesterase (AChE) in cells. Also disclosed herein are methods of using the disclosed compounds and compositions for inhibiting the spread of Tau seeds from donor cells to recipient cells. Further disclosed herein are methods of using the disclosed compounds and compositions for treating or preventing a neurodegenerative disorder, such as a tauopathy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).