Abstract: A temporal-spectral multiplexing sensor for simultaneous or near simultaneous spatial-temporal-spectral analysis of an incoming optical radiation field. A spectral encoder produces a time series of spectrally encoded optical images at a high sampling rate. A series of full panchromatic spectrally encoded optical images are collected at a rate similar to the sampling rate. A detector records at least one spatial region of the spectrally encoded optical image. A processor is configured to process two series of spectrally encoded optical images to produce an artifact-free spectral image. The processing includes using the panchromatic images to normalize the spectrally encoded images, and decoding the normalized encoded images to produce high fidelity spectral signatures, free of temporal artifacts due to fluctuations at frequencies slower than the sampling rate for polychromatic images.

Abstract: A temporal-spectral multiplexing sensor for simultaneous or near simultaneous spatial-temporal-spectral analysis of an incoming optical radiation field. A spectral encoder produces a time series of spectrally encoded optical images at a high sampling rate. A series of full panchromatic spectrally encoded optical images are collected at a rate similar to the sampling rate. A detector records at least one spatial region of the spectrally encoded optical image. A processor is configured to process two series of spectrally encoded optical images to produce an artifact-free spectral image. The processing includes using the panchromatic images to normalize the spectrally encoded images, and decoding the normalized encoded images to produce high fidelity spectral signatures, free of temporal artifacts due to fluctuations at frequencies slower than the sampling rate for polychromatic images.

Abstract: A system for acquiring both the spatial and spectral dimensions of a spectral image cube either simultaneously with a single frame acquisition, or sequentially with a small number of frames, using a sensor that uses an array of pixel-size, narrow wavelength bandpass filters placed in close proximity to a focal plane array (FPA), and for processing the acquired data to retrieve spectral image cubes at the pixel resolution of the FPA.

Abstract: A phage display library is formed by a plurality of recombinant phages; each of the plurality of recombinant phages comprising an M13-derived expression vector; the M13-derived expression vector comprising a polynucleotide sequence encoding a randomized peptide, wherein the randomized peptide is a variable region of a human IgG1 heavy chain; the randomized peptide is expressed in absence of an immunoglobulin light chain protein on an outer surface of a recombinant phage of the phage display antibody library; and a protein product expressed by a recombinant phage of the phage display antibody library fuses with a human immunoglobulin constant region to form a full human IgG1 heavy chain molecule. The phage display library can be utilized to identify candidate antibodies that can bind to receptor Axl and other receptors.

Abstract: A tunable laser source that includes multiple gain elements and uses a spatial light modulator in an external cavity to produce spectrally tunable output is claimed. Several designs of the external cavity are described, targeting different performance characteristics and different manufacturing costs for the device. Compared to existing devices, the tunable laser source produces high output power, wide tuning range, fast tuning rate, and high spectral resolution.

Abstract: A system for controlling the uniformity of combustion over a range of operating conditions in a combustor with a plurality of fuel nozzles. The system includes a number of optical sensors, each sensor comprising an optical probe that collects naturally occurring optical radiation emanating from a segment of the combustor or combustor exhaust, and at least one transducer that receives the radiation collected by the probes, compares the intensity of collected radiation from each sensor in a plurality of spectral pass-bands that are indicative of the fuel/air ratio in the combustor segments, and produces output signals that are indicative of the state of combustion in the combustor segments. A control system receives the output signals from the transducers and in response controls the fuel flow to the fuel nozzles to achieve an output from each of the sensors that has been determined to be indicative of a predetermined state of combustion.

Abstract: A single-shot spectral imager or imaging system which acquires multiplexed spatial and spectral data in a single snapshot with high optical collection efficiency and with the speed limited only by the readout time of the detector circuitry. The imager uses dispersive optics together with spatial light modulators to encode a mathematical transform onto the acquired spatial-spectral data. A multitude of encoded images is recorded simultaneously on a focal plane array and subsequently decoded to produce a spectral/spatial hypercube.

Abstract: An adaptive spectral sensor, and methods of using the sensor. The sensor uses a programmable band pass transmission filter to produce both contrast signals, which discriminate specific target materials from background materials by comparing spectral signatures in hardware, and scene radiance spectra. The adaptive spectral sensor may measure one or more scene spectra and may form a spectral image. The sensor may automatically adjust to changing spectral, spatial and temporal conditions in the environment being monitored, by changing sensor resolution in those dimensions and by changing the detection band pass. The programmable band pass can be changed on-the-fly in real time to implement a variety of detection techniques in hardware or measure the spatial or spectral signatures of specific materials and scenes.

Abstract: A tunable laser source that includes multiple gain elements and uses a spatial light modulator in an external cavity to produce spectrally tunable output is claimed. Several designs of the external cavity are described, targeting different performance characteristics and different manufacturing costs for the device. Compared to existing devices, the tunable laser source produces high output power, wide tuning range, fast tuning rate, and high spectral resolution.

Abstract: A single-shot spectral imager or imaging system which acquires multiplexed spatial and spectral data in a single snapshot with high optical collection efficiency and with the speed limited only by the readout time of the detector circuitry. The imager uses dispersive optics together with spatial light modulators to encode a mathematical transform onto the acquired spatial-spectral data. A multitude of encoded images is recorded simultaneously on a focal plane array and subsequently decoded to produce a spectral/spatial hypercube.

Abstract: A spectral encoder for producing spectrally selected images of a radiation field containing multiple spectral components. An imaging spectrograph defines a first optical path that produces from the input radiation field a spectrally dispersed image comprising multiple spectral components displaced along a dispersion direction. Spectral pass bands are encoded on the dispersed image by a programmable spatial light modulator using one or more spatial masks. The imaging spectrograph further defines a second optical path that reverses the spectral dispersion of the first path and produces a spectrally-encoded polychromatic output image containing only those spectral components encoded by the spatial mask. The first and second optical paths share a common dispersing element. A detector records at least one spatial region of the spectrally encoded output image.

Abstract: A spectral encoder for producing spectrally selected images of a radiation field containing multiple spectral components. An imaging spectrograph defines a first optical path that produces from the input radiation field a spectrally dispersed image comprising multiple spectral components displaced along a dispersion direction. Spectral pass bands are encoded on the dispersed image by a programmable spatial light modulator using one or more spatial masks. The imaging spectrograph further defines a second optical path that reverses the spectral dispersion of the first path and produces a spectrally-encoded polychromatic output image containing only those spectral components encoded by the spatial mask. The first and second optical paths share a common dispersing element. A detector records at least one spatial region of the spectrally encoded output image.

Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.

Abstract: Methods for transmitting digitized x-ray radiographs are disclosed. Digitization may be carried out through use of a digital camera or through digital radiography. After digitization is complete, in certain embodiments of the present invention, the digitized x-ray radiograph is encrypted. In other embodiments, a virtual private network is established. In still other embodiments, either before or after generating a digitized x-ray image, written notice to a human subject concerning the identity of one or more authorized intended recipients may be provided. All embodiments include transmission of the digitized x-ray radiograph.

Abstract: Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.

Abstract: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.

Abstract: The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.

Abstract: Monoclonal antibodies that specifically bind to an extracellular domain of a flt-1 receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.

Abstract: A system and method for remotely determining at least one of the temperature of, and the relative concentrations of species making up, a hot fluid, based on the spectral structure of radiation emitted from the fluid. Thermal radiation over a field of view including the hot fluid is collected. At least a portion of the emission spectrum from the collected radiation is resolved. The resolved emission spectrum is resolved into spectra that are characteristic of specific emitting species and emitter temperatures. The temperature of, and the relative concentrations of species making up, the hot fluid, are determined from the relative amounts of at least two resolved spectra.

Abstract: The present invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages, one comprising a target or target library and the other comprising a target-binder library, and selecting to eliminate the non-paired targets and binders. Also related are complexes comprising target and target binders, as well as antibodies that bind to these complexes. Additionally, the present invention also relates to nucleic acids encoding target and target binders peptides. The invention also relates to the use of the sequence information inherent in the targets and target binders for target validation using in silico approaches. In addition, the invention also relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery.