Patents by Inventor Neil I. Goldstein

Neil I. Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for indentifying anti-cancer agents
    Patent number: 6413717
    Abstract: Methods are provided for identifying agents that modulate the expression of genes, such as genes encoding tumor suppressor or tumor-promoting proteins. The methods generally comprise screening candidate agents for the ability to enhance expression of a tumor suppressor gene, such as mda-7, or for the ability to inhibit expression of a tumor-promoting gene within a cell. Modulating agents may be used, for example, within anti-cancer therapies.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: July 2, 2002
    Assignee: Corixa Corporation
    Inventors: Yilong Sun, Paul B. Fisher, Neil I. Goldstein
  • Monoclonal antibodies specific to VEGF receptors and uses thereof
    Patent number: 6365157
    Abstract: Monoclonal antibodies that specifically bind to an extracellular domain of a flt-1 receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: April 2, 2002
    Assignee: ImClone Systems, Inc.
    Inventors: Patricia Rockwell, Neil I. Goldstein
  • MONOCLONAL ANTIBODIES SPECIFIC TO VEGF RECEPTORS AND USES THEREOF
    Publication number: 20020009750
    Abstract: Monoclonal antibodies that specifically bind to an extracellular domain of flt-1 receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.
    Type: Application
    Filed: September 22, 1999
    Publication date: January 24, 2002
    Inventors: PATRICIA ROCKWELL, NEIL I. GOLDSTEIN
  • Monoclonal antibodies specific to VEGF receptors and uses thereof
    Patent number: 5955311
    Abstract: Monoclonal antibodies that specifically bind to an extracellular domain of a VEGF receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: September 21, 1999
    Assignee: ImClone Systems Incorporated
    Inventors: Patricia Rockwell, Neil I. Goldstein
  • Single chain antibodies specific to VEGF receptors
    Patent number: 5874542
    Abstract: Monoclonal antibodies that specifically bind to an extracellular domain of a VEGF receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: February 23, 1999
    Assignee: Imclone Systems Incorporated
    Inventors: Patricia Rockwell, Neil I. Goldstein
  • Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
    Patent number: 5861499
    Abstract: Nucleic acid molecules comprising a nucleic acid sequence that encodes an amino acid sequence wherein the amino acid sequence consists of the variable region or of the hypervariable region of a monoclonal antibody that specifically binds to an extracellular domain of a VEGF receptor and neutralizes activation of the receptor.
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: January 19, 1999
    Assignee: ImClone Systems Incorporated
    Inventors: Patricia Rockwell, Neil I. Goldstein
  • Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
    Patent number: 5840301
    Abstract: Monoclonal antibodies that specifically bind to an extracellular domain of a VEGF receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: November 24, 1998
    Assignee: ImClone Systems Incorporated
    Inventors: Patricia Rockwell, Neil I. Goldstein
  • Recombinant hybrid porin epitopes
    Patent number: 5547670
    Abstract: The present invention provides a polypeptide that is non-toxic in E. coli. The disclosed polypeptide comprises at least one antigenic sequence present in P.IA of N. gonorrhoeae and at least one antigenic sequence present in P.IB of N. gonorrhoeae. Further, the disclosed polypeptide of the invention is fused to a carrier peptide.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: August 20, 1996
    Assignee: Imclone Systems Incorporated
    Inventors: Neil I. Goldstein, Charles T. Tackney
  • Method of producing monoclonal anti-idiotype antibody
    Patent number: 4699880
    Abstract: A method for determining the presence of an antigen in a liquid sample. The method includes incubating the sample with an antibody which specifically binds an epitope on the antigen in the presence of a given quantity of an anti-idiotype antibody which specifically binds an epitope on the hypervariable region of the antibody. Also, a method of producing a monoclonal anti-idiotype antibody by fusing lymphocytes from an animal in which a tumor capable of secreting idiotype antibodies has been grown, with myeloma cells.
    Type: Grant
    Filed: September 25, 1984
    Date of Patent: October 13, 1987
    Assignee: Immunomedics, Inc.
    Inventor: Neil I. Goldstein