Patents by Inventor Neil J. Butt

Neil J. Butt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
    Patent number: 6958392
    Abstract: A method for isolating nucleic acid which comprises: (a) applying a sample comprising cells containing nucleic acid to a filter, whereby the cells are retained as a retentate and contaminants are removed; (b) lysing the retentate from step (a) while the retentate is retained by the filter to form a cell lysate containing the nucleic acid; (c) filtering the cell lysate with the filter to retain the nucleic acid and remove remaining cell lysate; (d) optionally washing the nucleic acid retained by the filter; and (e) eluting the nucleic acid, wherein the filter composition and dimensions are selected so that the filter is capable of retaining the cells and the nucleic acid. Additionally, there is provided a substrate for lysing cells and purifying nucleic acid having a matrix and a coating and an integrity maintainer for maintaining the purified nucleic acid.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: October 25, 2005
    Assignee: Whatman, Inc.
    Inventors: Galina N. Fomovskaia, Martin A. Smith, Mikhail A. Fomovsky, Neil J. Butt
  • Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies
    Patent number: 6670128
    Abstract: The present invention provide methods for utilizing spent leukodepletion filter devices as a source of material for the isolation and analysis of genomic DNA (gDNA), including polymorphism, genotyping, and pharmacogenomic studies. Cellular retentate with the filter contains leukocytes, which are lysed to release the nuclei. The nuclei are lysed or ruptured to release genomic DNA, which is then isolated and used for subsequent analysis.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: December 30, 2003
    Assignee: Whatman, Inc.
    Inventors: Martin A. Smith, Galina N. Fomovskaia, Mikhail A. Fomovsky, Neil J. Butt, Matthew Baker
  • Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
    Publication number: 20020150907
    Abstract: A method for isolating nucleic acid which comprises:
    Type: Application
    Filed: July 18, 2001
    Publication date: October 17, 2002
    Inventors: Galina N. Fomovskaia, Martin A. Smith, Mikhail A. Fomovsky, Neil J. Butt
  • Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies
    Publication number: 20020090623
    Abstract: The present invention provide methods for utilizing spent leukodepletion filter devices as a source of material for the isolation and analysis of genomic DNA (gDNA), including polymorphism, genotyping, and pharmacogenomic studies. Cellular retentate with the filter contains leukocytes, which are lysed to release the nuclei. The nuclei are lysed or ruptured to release genomic DNA, which is then isolated and used for subsequent analysis.
    Type: Application
    Filed: August 15, 2001
    Publication date: July 11, 2002
    Inventors: Martin A. Smith, Galina N. Fomovskaia, Mikhail A. Fomovsky, Neil J. Butt, Matthew Baker