Abstract: Provided herein are compounds, such as compounds of Formula (I), Formula (I-A), Formula (I-B), or pharmaceutically acceptable salts of any one there, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: In one aspect, a defect detection system for detecting wallboard defects includes an imaging device, a board detection system, a machine-learned defect detection model, and a corrective action instruction system. The imaging device is configured to scan a wallboard and generate imaging data for respective pixels of the wallboard. The board detection system is configured to process the imaging data and to detect and localize individual board images within the imaging data. The machine-learned defect detection model is configured to process the individual board images, the machine-learned defect detection model having been trained to generate board classification data indicative of one or more classifications associated with the wallboard. The corrective action instruction system is configured to generate one or more corrective action instructions relative to the wallboard based on the board classification data generated by the machine-learned defect detection model.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product aspects, and/or combinations and sub-combinations thereof, for locating a remote control. An example aspect operates by transmitting an encoded radio frequency to wake-up a proximate television remote and initiate a “find my remote” process. A passive circuit integrated within the television remote receives the transmitted encoded radio frequency signal. Once awake, the television remote may provide an indicator of location to a proximate user. Another example aspect operates by transmitting high frequency radar to a radar transponder circuit within the television remote so that it becomes visible to the radar. Once the transponder is activated, the radar may locate the television remote relative to the television and display the location of the television remote on-screen, on a mobile device screen, or other locator indicator constructs.

Abstract: Provided herein are KRAS modulating compounds, such as compounds of Formula (I), (II) (II*) (III) or pharmaceutically acceptable salts, solvates, stereoisomers, atom labelled, or tautomers of any of the foregoing, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: Provided herein are compounds, such as compounds of Formula (I), Formula (I-A), Formula (I-B), or pharmaceutically acceptable salts of any one there, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: The present invention concerns an antimicrobial component for a wound dressing and wound dressing comprising the same. The antimicrobial component comprises a source of silver ions, a quaternary ammonium salt and an organic acid. The antimicrobial component demonstrates improved antimicrobial efficacy across a broad spectrum of microorganisms and can be utilised in wound dressings where increased antimicrobial efficacy and a broad spectrum of efficacy is required across multiple microorganisms. This will assist clinicians when treating infected chronic wounds or preventing surgical site infections.

Abstract: An exterior installable air valve for a tire rim using an exterior operated nut compressing a gasket against a wedge to expand the gasket for sealing to a wheel rim.

Abstract: Provided herein are compounds, such as compounds of Formula (I), Formula (I-A), Formula (I-B), or pharmaceutically acceptable salts of any one there, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: Provided herein are KRAS modulating compounds, such as compounds of Formula (I), (II), (II*), (III) or pharmaceutically acceptable salts, solvates, stereoisomers, atom labelled, or tautomers of any of the foregoing, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: A tracking system includes one or more wireless tags, a sensing device, and a processor. The sensing device is configured to generate sensing data representative of one or more people or objects in a scene. The processor is configured to detect the presence of the wireless tags within the scene. The processor is further configured to receive sensing data representative of objects in the scene and to identify tracks corresponding to the objects. The processor is further configured to process the received sensing data to generate a track descriptor associated with each of the identified objects, each track descriptor being representative of attributes of the corresponding object. The processor is also configured to analyze track descriptors associated with tracks when a wireless tag is present in the target scene. The processor is further configured to determine tracks associated the wireless tags based on the track descriptors present in the scene.

Abstract: Provided herein are KRAS modulating compounds, such as compounds of Formula (I), (II), (II*), (III) or pharmaceutically acceptable salts, solvates, stereoisomers, atom labelled, or tautomers of any of the foregoing, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: The present invention concerns extensible absorbent wound dressings. The wound dressing has a wound contact layer having a proximal surface facing toward the wound and a distal surface facing away from the wound, and a backing layer having a proximal surface facing toward the wound and a distal surface facing away from the wound, the backing layer having an absorbent region located on a proximal surface thereof, the absorbent region comprising a plurality of discrete absorbent members, wherein the backing layer is configured to be positioned over the wound contact layer, such that the absorbent region is located adjacent to the distal surface of the wound contact layer, and wherein the absorbent region and the wound contact layer are configured to be detached at least in an area inside a perimeter of the absorbent region. The absorbent wound dressings of the present invention can be used to dress so-called truly three-dimensional anatomical areas, such as for example a knee or an elbow.

Abstract: The present invention concerns extensible absorbent pads for wound dressings. The absorbent pad has a plurality of fenestrations therein, wherein the fenestrations are arranged in a pattern about a central point. The pattern comprises one or more fenestrations having symmetry about a cardinal axis and one or more fenestrations having symmetry about an intercardinal axis, wherein the cardinal and intercardinal axes cross at the central point. The absorbent pads of the present invention can be used in advanced wound care dressing applications where additional stretch and extensibility of the dressing will assist clinicians in applying the dressing to difficult to dress anatomical areas.

Abstract: A liquid electrode tip has a housing with a top, a bottom and at least one peripheral side wall. The housing has a liquid inlet and a liquid outlet. The liquid outlet is located at the top of the housing. A solution reservoir is positioned within the housing. The solution reservoir has a solution inlet in fluid communication with the liquid inlet and a solution outlet in fluid communication with the liquid outlet. A conductor is positioned within the housing with at least a portion of the conductor being submerged by a liquid in the solution reservoir. A staging area at the top of the housing is provided into which the liquid from the solution reservoir flows from the liquid outlet.

Abstract: A system for landing an unmanned aerial vehicle (UAV) at a destination includes a landing coordination control unit that is configured to switch the UAV from a normal operating mode to a landing mode in response to the UAV entering a regulated airspace in relation to the destination. The normal operating mode includes normal instructions for flying and navigating to the destination. The landing mode includes landing instructions for a landing sequence into a landing zone at the destination.

Abstract: A solution electrode glow discharge apparatus has a housing that contains a solid electrode. The solid electrode has a head and a tip. The tip of the solid electrode extends outwards from the housing. At least a portion of the head of the solid electrode is positioned with an electrical and thermal conducting block. An adjustable-polarity power supply is provided in communication with the solid electrode. A cooling mechanism is provided for cooling the electrical and thermal conducting block.

Abstract: Some systems include an illuminator configured to illuminate a scene, a detector configured to receive electromagnetic radiation from the scene, one or more retroreflective tags, and an image processor. Each of the one or more retroreflective tags is attached to or positioned near a corresponding target and is configured to reflect electromagnetic radiation from the illuminator toward the detector. The image processor can identify electromagnetic radiation reflected by one or more retroreflective tags to determine the presence of one or more retroreflective tags and corresponding targets in the scene. Retroreflective tags can include retroreflective portions and non-retroreflective portions such that, when electromagnetic radiation is incident upon the retroreflective tag, the retroreflective tag reflects the electromagnetic radiation in a pattern that corresponds to a code uniquely corresponding to the target.

Abstract: A liquid electrode tip has a housing with a top, a bottom and at least one peripheral side wall. The housing has a liquid inlet and a liquid outlet. The liquid outlet is located at the top of the housing. A solution reservoir is positioned within the housing. The solution reservoir has a solution inlet in fluid communication with the liquid inlet and a solution outlet in fluid communication with the liquid outlet. A conductor is positioned within the housing with at least a portion of the conductor being submerged by a liquid in the solution reservoir. A staging area at the top of the housing is provided into which the liquid from the solution reservoir flows from the liquid outlet.

Abstract: Systems for detecting occupancy of an area comprising one or more zones can include one or more sensors and one or more processors configured to receive sensor data from the one or more sensors over time. The one or more processors can be further configured to receive or store data about an arrangement of the zones in the area. The one or more processors can apply a probabilistic model considering the sensor data received over time to determine the number of subjects in each zone by determining a most likely current state of occupancy of the area among a plurality of possible scenarios.