Abstract: A system of robotic surgery includes components capable of drilling a bore in the cranium of a patient in connection with craniotomy and other cranial surgeries. A perforator associated with such system is controlled by suitable computer-implemented instructions to maintain the perforator tip along a desired trajectory line while moving the perforator bit at locations proximal to such perforator tip in a circular motion, thereby imparting a conical oscillation to the perforator bit relative to the trajectory line. The angle at which the perforator bit is oscillated relative to such trajectory line results in the bore formed in the cranium having a diameter larger than the bit diameter, and the larger diameter and related conical oscillation is selected so as to reduce frictional force opposing withdrawal of the bit from the situs of the bore, thereby reducing the risk of jamming of the bit during its associated operations.

Abstract: Devices, systems, and methods for providing a degree of freedom to a guide tube associated with a robotic surgical system. The surgical robot system may be configured to have six degrees of freedom associated with a vertical lift, rotation about a shoulder, rotation about an elbow, roll of a forearm, pitch of the end-effector, and rotation of a guide tube independent from the end-effector. The robotic surgical system allows for the proper orientation of an instrument in the guide tube along a trajectory to the operational site of a patient.

Abstract: Techniques are disclosed for systems and methods for video based sensor fusion with respect to mobile structures. A mobile structure may include at least one imaging module and multiple navigational sensors and/or receive navigational data from various sources. A navigational database may be generated that includes data from the imaging module, navigational sensors, and/or other sources. Aspects of the navigational database may then be used to generate an integrated model, forecast weather conditions, warn of dangers, identify hard to spot items, and generally aid in the navigation of the mobile structure.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product aspects, and/or combinations and sub-combinations thereof, for locating a remote control. An example aspect operates by transmitting an encoded radio frequency to wake-up a proximate television remote and initiate a “find my remote” process. A passive circuit integrated within the television remote receives the transmitted encoded radio frequency signal. Once awake, the television remote may provide an indicator of location to a proximate user. Another example aspect operates by transmitting high frequency radar to a radar transponder circuit within the television remote so that it becomes visible to the radar. Once the transponder is activated, the radar may locate the television remote relative to the television and display the location of the television remote on-screen, on a mobile device screen, or other locator indicator constructs.

Abstract: System and method of registering a medical image of a patient in an imaging space to the patient in a physical space preferably without the use of any embedded radiopaque fiducials in medical images is provided. In one way, intra-op 2D medical images are used to register a pre-op unregistered 3D medical image. The 2D medical images are registered based on simultaneous tracking of the tracking markers on the imaging device and on the patient by a tracking device at the time of image capture. The 2D images are matched to corresponding simulated 2D images generated from the pre-op 3D image volume. Thus, registration of a pre-op 3D image to the patient is accomplished without performing another 3D scan of the patient.

Abstract: A surgical robot system includes a robot having a robot base and a robot arm coupled to the robot base, and a surgical retractor. The surgical retractor includes a retractor frame, a coupler, blades, a force and/or torque sensor, and a force and/or torque feedback determination unit. The retractor frame includes arms that are translatably and/or pivotably connected to the retractor frame. The coupler releasably attaches the retractor frame to the robot arm. The blades are each coupled to and extend away from a distal end of one of the arms. The force and/or torque sensor is connected to the blades and indicates an amount of force and/or torque being applied to the blades from contact with material of a surgical site. The force and/or torque feedback determination unit determines the amount of force and/or torque being applied to the blades based on the indication.

Abstract: Provided herein are KRAS modulating compounds, such as compounds of Formula (I), (II) (II*) (III) or pharmaceutically acceptable salts, solvates, stereoisomers, atom labelled, or tautomers of any of the foregoing, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: A surgical robot system includes a surgical robot, a robot arm connected to such surgical robot, and an end-effector connected to the robot arm. A registration fixture is used in conjunction with various registration systems in the surgical robot system. Such registration systems likewise include a detachable base in the form of a detachable dynamic reference base, along with an associated mount, the dynamic reference base and mount having certain features which permit the dynamic reference base to be selectively attached, detached, and reattached at different phases of an operation, whether pre-operative or intra-operative, and such successive attachments are done without the dynamic reference base, and tracking markers associated therewith, losing registration. Related methods allow for the more efficient and effective performance of operations by virtue of the dynamic reference base maintaining its registration during attachments and reattachments.

Abstract: Provided herein are compounds, such as compounds of Formula (I), Formula (I-A), Formula (I-B), or pharmaceutically acceptable salts of any one there, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: The present invention concerns an antimicrobial component for a wound dressing and wound dressing comprising the same. The antimicrobial component comprises a source of silver ions, a quaternary ammonium salt and an organic acid. The antimicrobial component demonstrates improved antimicrobial efficacy across a broad spectrum of microorganisms and can be utilised in wound dressings where increased antimicrobial efficacy and a broad spectrum of efficacy is required across multiple microorganisms. This will assist clinicians when treating infected chronic wounds or preventing surgical site infections.

Abstract: An exterior installable air valve for a tire rim using an exterior operated nut compressing a gasket against a wedge to expand the gasket for sealing to a wheel rim.

Abstract: Provided herein are compounds, such as compounds of Formula (I), Formula (I-A), Formula (I-B), or pharmaceutically acceptable salts of any one there, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: Provided herein are KRAS modulating compounds, such as compounds of Formula (I), (II), (II*), (III) or pharmaceutically acceptable salts, solvates, stereoisomers, atom labelled, or tautomers of any of the foregoing, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: A tracking system includes one or more wireless tags, a sensing device, and a processor. The sensing device is configured to generate sensing data representative of one or more people or objects in a scene. The processor is configured to detect the presence of the wireless tags within the scene. The processor is further configured to receive sensing data representative of objects in the scene and to identify tracks corresponding to the objects. The processor is further configured to process the received sensing data to generate a track descriptor associated with each of the identified objects, each track descriptor being representative of attributes of the corresponding object. The processor is also configured to analyze track descriptors associated with tracks when a wireless tag is present in the target scene. The processor is further configured to determine tracks associated the wireless tags based on the track descriptors present in the scene.

Abstract: Provided herein are KRAS modulating compounds, such as compounds of Formula (I), (II), (II*), (III) or pharmaceutically acceptable salts, solvates, stereoisomers, atom labelled, or tautomers of any of the foregoing, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: The present invention concerns extensible absorbent wound dressings. The wound dressing has a wound contact layer having a proximal surface facing toward the wound and a distal surface facing away from the wound, and a backing layer having a proximal surface facing toward the wound and a distal surface facing away from the wound, the backing layer having an absorbent region located on a proximal surface thereof, the absorbent region comprising a plurality of discrete absorbent members, wherein the backing layer is configured to be positioned over the wound contact layer, such that the absorbent region is located adjacent to the distal surface of the wound contact layer, and wherein the absorbent region and the wound contact layer are configured to be detached at least in an area inside a perimeter of the absorbent region. The absorbent wound dressings of the present invention can be used to dress so-called truly three-dimensional anatomical areas, such as for example a knee or an elbow.

Abstract: The present invention concerns extensible absorbent pads for wound dressings. The absorbent pad has a plurality of fenestrations therein, wherein the fenestrations are arranged in a pattern about a central point. The pattern comprises one or more fenestrations having symmetry about a cardinal axis and one or more fenestrations having symmetry about an intercardinal axis, wherein the cardinal and intercardinal axes cross at the central point. The absorbent pads of the present invention can be used in advanced wound care dressing applications where additional stretch and extensibility of the dressing will assist clinicians in applying the dressing to difficult to dress anatomical areas.

Abstract: A liquid electrode tip has a housing with a top, a bottom and at least one peripheral side wall. The housing has a liquid inlet and a liquid outlet. The liquid outlet is located at the top of the housing. A solution reservoir is positioned within the housing. The solution reservoir has a solution inlet in fluid communication with the liquid inlet and a solution outlet in fluid communication with the liquid outlet. A conductor is positioned within the housing with at least a portion of the conductor being submerged by a liquid in the solution reservoir. A staging area at the top of the housing is provided into which the liquid from the solution reservoir flows from the liquid outlet.

Abstract: A system for landing an unmanned aerial vehicle (UAV) at a destination includes a landing coordination control unit that is configured to switch the UAV from a normal operating mode to a landing mode in response to the UAV entering a regulated airspace in relation to the destination. The normal operating mode includes normal instructions for flying and navigating to the destination. The landing mode includes landing instructions for a landing sequence into a landing zone at the destination.