Patents by Inventor Neil Kubica

Neil Kubica has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS OF MODIFIED TREMS AND USES THEREOF
    Publication number: 20240175020
    Abstract: The invention relates generally to tRNA-based effector molecules (TREMs) comprising an asialoglycoprotein receptor (ASGPR) binding moiety, as well as compositions and methods relating thereto.
    Type: Application
    Filed: December 23, 2021
    Publication date: May 30, 2024
    Inventors: Theonie Anastassiadis, David Charles Donnell Butler, Neil Kubica, Qingyi Li, Armand Gatien Ngounou Wetie, Guangliang Wang
  • Nucleic acid-binding photoprobes and uses thereof
    Patent number: 11807623
    Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 7, 2023
    Assignee: Arrakis Therapeutics, Inc.
    Inventors: Gnanasambandam Kumaravel, Jennifer C. Petter, Jonathan Craig Blain, Donovan Noel Chin, Chao Fang, Herschel Mukherjee, Neil Kubica
  • NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF
    Publication number: 20230312520
    Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
    Type: Application
    Filed: January 17, 2023
    Publication date: October 5, 2023
    Inventors: Gnanasambandam KUMARAVEL, Jennifer C. PETTER, Jonathan Craig BLAIN, Donovan Noel CHIN, Chao FANG, Herschel MUKHERJEE, Neil KUBICA
  • TREM COMPOSITIONS AND METHODS RELATING THERETO
    Publication number: 20230203510
    Abstract: The disclosure relates generally to methods of modulating a production parameter of an RNA corresponding to, or polypeptide encoded by, a nucleic acid sequence comprising an endogenous ORF having a premature termination codon, comprising administering a tRNA-based effector molecule having a non-naturally occurring modification.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 29, 2023
    Inventors: Theonie Anastassiadis, David Charles Donnell Butler, Neil Kubica, Qingyi Li
  • TREM COMPOSITIONS AND USES THEREOF
    Publication number: 20230054178
    Abstract: The invention relates generally to tRNA-based effector molecules having a non-naturally occurring modification and methods relating thereto.
    Type: Application
    Filed: November 4, 2021
    Publication date: February 23, 2023
    Inventors: Theonie Anastassiadis, David Charles Donnell Butler, Neil Kubica, Qingyi Li
  • NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF
    Publication number: 20190270723
    Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
    Type: Application
    Filed: November 30, 2018
    Publication date: September 5, 2019
    Inventors: Gnanasambandam Kumaravel, Jennifer C. Petter, Jonathan Craig Blain, Donovan Noel Chin, Chao Fang, Herschel Mukherjee, Neil Kubica