Abstract: The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.

Abstract: The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.

Abstract: Disclosed are an apparatus and method for separately detecting and measuring specularly reflected light and diffusely reflected light following illumination of an eye by light. The apparatus and method of the present invention facilitates substantial separation of the diffusely reflected light from light specularly reflected from the eye after passing through one or more elements of the eye, for example, the cornea, lens, retinal vasculature, the nerve fibre layer and/or the photoreceptors. The collection of these separate streams of independent optical signals to appropriate detection systems provides specificity and accuracy in determination of optical properties of one or more elements of the eye.

Abstract: Disclosed are an apparatus and method for separately detecting and measuring specularly reflected light and diffusely reflected light following illumination of an eye by light. The apparatus and method of the present invention facilitates substantial separation of the diffusely reflected light from light specularly reflected from the eye after passing through one or more elements of the eye, for example, the cornea, lens, retinal vasculature, the nerve fibre layer and/or the photoreceptors. The collection of these separate streams of independent optical signals to appropriate detection systems provides specificity and accuracy in determination of optical properties of one or more elements of the eye.

Abstract: A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.

Abstract: A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.

Abstract: The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.

Abstract: Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

Abstract: Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

Abstract: Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

Abstract: Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

Abstract: Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

Abstract: Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.