Patents by Inventor Neil Mathews

Neil Mathews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10835700
    Abstract: Various improvements are provided to breathing training, monitoring and/or assistance devices. A portable device is provided which optionally includes a gas canister, a feedback system for implementing pressure control, and a visual output for indicating adherence to a breathing exercise to the user. The pressure control may provide regulation of different pressures for inhalation and exhalation.
    Type: Grant
    Filed: September 18, 2016
    Date of Patent: November 17, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Manuela Lunz, Teunis Johannes Vink, Leendert Van Der Tempel, Mareike Klee, Lenneke Van Genugten, Neil Francis Joye, Franciscus Hendrikus Van Heesch, Edwin Van Rutten, Jeroen Herman Lammers, Gabriele Spina, Albertus Cornelis Den Brinker, Kevin Paul Warmerdam, Sander Kruitwagen, Andrew Mitchell, Denny Mathew, Achim Gerhard Rolf Koerber, Frank Bies
  • Patent number: 10106539
    Abstract: Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C1-3 alkylene, C2-3 alkenylene or C2-3 alkynylene; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, C1-6 haloalkyl, nitro, —CN, —N(R2)2, —OR2, —SR2, —S(=0)R2, or —S(=0)2R2; each R2 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: October 23, 2018
    Assignee: REVIRAL LIMITED
    Inventors: Stuart Cockerill, Neil Mathews, Simon Ward, Graham Lunn, Michael Paradowski, Jose Miguel Gascon Simorte
  • Patent number: 9809575
    Abstract: Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, —(CH2)p—, —X—, —CH2—X—, or —X—CH2—; X is —O—, —S—, —N(R2)—, >C?O, >S(?O), >S(?O)2, —O—C(?O)—, —C(?O)—O—, N(R2)—C(?O)—, or —C(?O)—N(R2)—; each L is independently a single bond, C1-3alkylene, C2-3alkenylene or C2-3alkynylene; R1 is C1-6alkyl, C2-6alkenyl or C2-6alkynyl, each of which is unsubstituted or substituted; each Z is independently —N(R2)2, —OR2, —SR2, —S(?O)R2, —S(?O)2R2; each R2 is independently hydrogen, C1-6alkyl, C2-6alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: November 7, 2017
    Assignee: ReViral Limited
    Inventors: Stuart Cockerill, Christopher Pilkington, James Lumley, Richard Angell, Neil Mathews
  • Publication number: 20170305908
    Abstract: Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C1-3 alkylene, C2-3 alkenylene or C2-3 alkynylene; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12- membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, C1-6 haloalkyl, nitro, —CN, —N(R2)2, —OR2, —SR2, —S(?0)R2, or —S(?0)2R2; each R2 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
    Type: Application
    Filed: October 6, 2015
    Publication date: October 26, 2017
    Applicant: REVIRAL LIMITED
    Inventors: Stuart Cockerill, Neil Mathews, Simon Ward, Graham Lunn, Michael Paradowski, Jose Miguel Gascon Simorte
  • Publication number: 20140308282
    Abstract: Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, —(CH2)p—, —X—, —CH2—X—, or —X—CH2—; X is —O—, —S—, —N(R2)—, >C?O, >S(?O), >S(?O)2, —O—C(?O)—, —C(?O)—O—, N(R2)—C(?O)—, or —C(?O)—N(R2)—; each L is independently a single bond, C1-3alkylene, C2-3alkenylene or C2-3alkynylene; R1 is C1-6alkyl, C2-6alkenyl or C2-6alkynyl, each of which is unsubstituted or substituted; each Z is independently —N(R2)2, —OR2, —SR2, —S(?O)R2, —S(?O)2R2; each R2 is independently hydrogen, C1-6alkyl, C2-6alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
    Type: Application
    Filed: November 12, 2012
    Publication date: October 16, 2014
    Applicant: re: Viral Ltd
    Inventors: Stuart Cockerill, Christopher Pilkington, James Lumley, Richard Angell, Neil Mathews
  • Patent number: 8008303
    Abstract: Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: August 30, 2011
    Assignee: AstraZeneca AB
    Inventors: Christopher James Wheelhouse, Alexander James Floyd Thomas, David John Bushnell, James Lumley, James Iain Salter, Malcolm Clive Carter, Neil Mathews, Christopher John Pilkington, Richard Martyn Angell
  • Publication number: 20100215618
    Abstract: The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6 and L are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of hepatitis C virus.
    Type: Application
    Filed: February 23, 2010
    Publication date: August 26, 2010
    Applicant: Arrow Therapeutics Limited
    Inventors: Malcolm Clive Carter, Neil Mathews
  • Publication number: 20100158863
    Abstract: A quinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof: formula (I) for use in treatment of prevention of a flaviviridae infection.
    Type: Application
    Filed: January 11, 2007
    Publication date: June 24, 2010
    Applicant: ARROW THERAPEUTICS LIMITED
    Inventors: Neil Mathews, Alexander James Floyd Thomas, Keith Charles Spencer, Nathalie Tiberghien, Christopher John Pilkington, Lyn Jennens, Surinder Chana, Ian John Fraser
  • Publication number: 20080311076
    Abstract: Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.
    Type: Application
    Filed: April 28, 2005
    Publication date: December 18, 2008
    Applicant: ARROW THERAPEUTICS LIMITED
    Inventors: Keith Charles Spencer, Helena Dennison, Neil Mathews, Michael Christopher Barnes, Surinder Singh Chana
  • Publication number: 20080267914
    Abstract: Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses (Ia), wherein R1 and R2 are the same or different and represent hydrogen, halogen, -L-O—R3, -L-O-L-A or -L-O-L?-A?, wherein each L is the same or different and represents a direct bond or a C1-C4 alkylene group; L? represents a direct bond or a C2-C4 alkylene group; R3 represents hydrogen, C1-C4 alkyl or C1-C4 haloalkyl; A represents a 5- to 10-membered heterocyclyl group; and A? represents a C6-C1 aryl group; wherein at least one of R1 and R2 is -L-O—R3, -L-O-L-A or -L-O-L?-A?.
    Type: Application
    Filed: October 9, 2006
    Publication date: October 30, 2008
    Inventors: Michael Christopher Barnes, Surinder Singh Chana, Helena Dennison, Lyn Jennens, Neil Mathews, Christopher John Pilkington, Keith Charles Spencer, Alexander James Floyd Thomas
  • Publication number: 20080255105
    Abstract: A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R1 is a C1-C6 alkyl group or a moiety -A1, -L1-A1, -A1-A1?, -L1-A1-A1?, -A1-L1-A1?, -A1-Y1-A1?, -A1-Het1-A1?, -L1-A1-Y1-A1?, -L1-A1-Het1-A1?, -L1-Het1-A1, -L1-Y1-A1, -L1-Y1-Het1-A1, -L1-Het1-Y1-A1, -L1-Y1-Het1-L1?, -A1-Y1-Het1-A1?, -A1-Het1-Y1-A1?, -A1-Het1-L1-A1?, -A1-L1-Het1-A1? or -L1-Het1-L1?; -A and B are the same or different and each represent a direct bond or a —CO—NR?—, —NR?—CO—, —NR?—CO2—, —CO—, —NR?—CO—NR?—, —NR?—S(O)2—, —S(O)2—NR?—, —SO2—, —NR?—, —NR?—CO—CO—, —CO—O—, —O—CO—, —(C1-C2 alkylene)-NR?— or —(C1-C2 hydroxyalkylene)-NR?-moiety, wherein R? and R? are the same or different and each represent hydrogen or C1-C4 alkyl; —R2 and R3 are the same or different and each represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or halogen; n and m are the same or different and each represent 0 or 1; R4 is a C1-C6 alkyl group or a moiety -A4, -L4-A4, -A4-A4?, -L4-A4-A4?, -A4-L4
    Type: Application
    Filed: September 18, 2006
    Publication date: October 16, 2008
    Inventors: Christopher James Wheelhouse, Alexander James Floyd Thomas, David John Bushnell, James Lumley, James Iain Salter, Malcolm Clive Carter, Neil Mathews, Christopher John Pilkington, Richard Martyn Angell
  • Publication number: 20080114008
    Abstract: Compounds of formula (I) are found to be active in inhibiting replication of flaviviridac Formula (I) wherein: X represents a direct bond or a moiety -L-NR—, wherein R is hydrogen or C1-C4 alkyl, and L represents a C1-C4alkylene, C6-C10 aryl or 5- to 10-membered heteroaryl moiety; either R1 and R2, together with the N atom to which they are attached, form a 5- to 10-membered heterocyclyl group or a 5- to 10-membered heteroaryl group, or R1 represents hydrogen, C6-C10 aryl, C1-C4 alkyl or C1-C4 hydroxyalkyl and R2 represents C6-C10 aryl, C1-C4 alkyl or C1-C4 hydroxyalkyl; and R3 represents a C6-C10 aryl, C3-C6 carbocyclyl, 5- to 10-membered heteroaryl or 5- to 10-membered heterocyclyl moiety, said aryl, carbocyclyl, heteroaryl and heterocyclyl groups being unsubstituted or substituted by 1, 2 or 3 substituents selected from halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, hydroxy, thiol, —NH2, C1-C4 hydroxyalkyl, C1-C4 thioalkyl and C1-C4aminoalkyl substituents.
    Type: Application
    Filed: January 30, 2006
    Publication date: May 15, 2008
    Applicant: ARROW THERAPEUTICS LIMITED
    Inventors: George Stuart Cockerill, Stephen Sean Flack, Neil Mathews, James Iain Salter
  • Publication number: 20050113377
    Abstract: The invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester or salt or solvate of such ester, of a compound of formula (I) in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H and C1-6alkyl or, together with the
    Type: Application
    Filed: October 27, 2004
    Publication date: May 26, 2005
    Inventors: Paul Beswick, Charanjit Bountra, Ian Campbell, Neil Mathews, Alan Naylor
  • Patent number: 6831097
    Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and n is 1-
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: December 14, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul John Beswick, Ian Baxter Campbell, Neil Mathews, Alan Naylor
  • Patent number: 6803463
    Abstract: A process for the preparation of a compound of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: October 12, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Neil Mathews, Richard Anthony Ward, Andrew Jonathan Whitehead
  • Publication number: 20040063949
    Abstract: Therapeutically active pyrazole derivatives of formula (I) wherein R1-R3 are as defined in the specification, processes for the preparation thereof, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterised by overexpression of transforming growth factor (TGF-), and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: July 31, 2003
    Publication date: April 1, 2004
    Inventors: Francoise Jeanne Gellibert, Charles David Hartley, Neil Mathews, James Michael Woolven
  • Publication number: 20040063745
    Abstract: Therapeutically active thiazole derivatives of formula (I) wherein R1, R2, X and X′ are as defined in the specification, processes for the preparation thereof, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterized by overexpression of transforming growth factor &bgr;(TAG-&bgr;), and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: July 31, 2003
    Publication date: April 1, 2004
    Inventors: Francoise Jeanne Gellibert, Charles David Hartley, Neil Mathews, James Michael Woolven
  • Publication number: 20030078267
    Abstract: 1
    Type: Application
    Filed: June 14, 2002
    Publication date: April 24, 2003
    Inventors: Neil Mathews, Richard Anthony Ward, Andrew Jonathan Whitehead
  • Publication number: 20030040517
    Abstract: The invention provides the compounds of formula (I) 1
    Type: Application
    Filed: August 5, 2002
    Publication date: February 27, 2003
    Inventors: Paul John Beswick, Charanjit Bountra, Ian Baxter Campbell, Neil Mathews, Alan Naylor
  • Publication number: 20030008872
    Abstract: The invention provides the compounds of formula (I) 1
    Type: Application
    Filed: August 5, 2002
    Publication date: January 9, 2003
    Inventors: Paul John Beswick, Ian Baxter Campbell, Neil Mathews, Alan Naylor