Abstract: In one aspect, therapeutic use, methods of treatment and kits comprising 177Lu-PSMA I&T are provided for subjects exhibiting prostate cancer progression following administration with one or more androgen receptor inhibitor agents.

Abstract: An evaporative cooling system that can be used to cool fluid and to cool an air supply to a building. The air supply to a cooling tower in a first evaporative system also having a fluid pump and a heat exchange element is cooled by the heat exchange element of a second evaporative cooling system. As a result, the inlet air wet bulb temperature of the primary cooling tower will be reduced, enhancing the cooling capacity of the primary cooling tower.

Abstract: There is provided a radiotherapy system comprising a linear accelerator, beam control circuitry for the linear accelerator, an electronic control apparatus for the control circuitry arranged to adjust properties thereof, and a monitor for detecting properties of the radiation beam produced by the linear accelerator, wherein the control apparatus is adapted to retain a set of beam properties and periodically activate the accelerator, measure the current beam properties via the monitor, compare the measured beam properties to the retained beam properties, and potentially adjust the control circuitry properties to align the beam properties towards the retained beam properties. The beam properties that are measured may include beam flatness and beam width. The retained beam properties can be the properties of the beam produced by the linear accelerator when new, or the properties of a standard beam. There is also provided a method for operating the system.

Abstract: We propose that during the factory testing of the linac, rather than simply confirming that the beam falls within the permissible ranges set out in the standard, the beam is in fact adjusted towards a standard signature. A new (or existing) linac could then be paired to a new linac, or to an existing linac, such as one that it is to operate alongside or one that it is to replace. Treatment plans would then be transferable between such pairs of linacs. In addition, the standard signature to which the linacs were approximated could be placed towards the centre of the permitted ranges, to produce linacs that were more reliable over the very long term. This requires a linac that has automatically adjustable parameters, so that a suitable programmed computer is able to monitor the output of the linac and adjust its operating parameters.

Abstract: An evaporative cooling system that can be used to cool fluid and to cool an air supply to a building. The air supply to a cooling tower in a first evaporative system also having a fluid pump and a heat exchange element is cooled by the heat exchange element of a second evaporative cooling system. As a result, the inlet air wet bulb temperature of the primary cooling tower will be reduced, enhancing the cooling capacity of the primary cooling tower.

Abstract: A cooling system that can be used to cool water and to cool an air supply to a building. The system employs a stand alone cooling tower and a night sky cooler. As a result, the water can be cooled below the ambient wet bulb temperature.