Patents by Inventor Neil Michael Smith

Neil Michael Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Processes
    Publication number: 20120220779
    Abstract: The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.
    Type: Application
    Filed: November 2, 2010
    Publication date: August 30, 2012
    Inventors: Claire Frances Crawford, Sandrine Garcia, Jonathan Paul Graham, Sandra Jane Harling, Nicholas Paul Henley, Stephen Andrew Hermitage, John Howard Hutchinson, Trevor Raymond Keel, Andrew Kennedy, Andrew McMurtrie Mason, Mark Simon Scott, Neil Michael Smith, Nicholas Simon Stock, Yuichi Tateno, Leontine Saskia Trouw, Peter Graham Turner, Christopher John Wallis, Robert David Willacy
  • Process for the production of purine derivatives and intermediates therefor
    Patent number: 6806375
    Abstract: Intermediates such as methyl 2,2-dimethyl-5-ethenyl-1,3-dioxane-5-carbonate useful to prepare antiviral compounds such as penciclovir and famciclovir are disclosed.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: October 19, 2004
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: Richard Freer, Graham Richard Geen, Thomas Weir Ramsay, Andrew Colin Share, Neil Michael Smith
  • Process for the production of purine derivatives and intermediates therefor
    Publication number: 20030130512
    Abstract: A process for preparing purine derivatives, such as famciclovir and penciclovir, by reacting two intermediates and using a palladium(0) catalyst and a ligand. Intermediates useful in the process are also claimed.
    Type: Application
    Filed: February 19, 2003
    Publication date: July 10, 2003
    Inventors: Richard Freer, Graham Richard Geen, Thomas Weir Ramsay, Andrew Colin Share, Neil Michael Smith
  • Process for the production of purine derivatives and intermediates therefor
    Patent number: 6555685
    Abstract: A process for preparing purine derivatives, such as famiciclovir and penciclovir, by reacting, in the presence of a palladium (0) catalyst and a ligand, a compound of the formula with a compound of the formula wherein X is H, OH or halo; Y is a leaving group; and R1 and R2 are selected independently from C1-12alkyl, aryl, C1-12alkylaryl, C1-12alkylsilyl, arylsilyl and C1-12alkyldiarylsilyl or are joined together to form a moiety of the formula wherein R3 and R4 are selected independently from H, C1-12alkyl and aryl.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: April 29, 2003
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: Richard Freer, Graham Richard Geen, Thomas Weir Ramsay, Andrew Colin Share, Neil Michael Smith