Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

Abstract: Methods and apparatus for processing an OFDM MIMO signal in a system having at least two transmitters arranged to transmit an output signal pair that includes operating a series of transformations on a pair of input signals so that each stream of the output signal pair contains decodable information from both streams of the input signal pair.

Abstract: Methods and apparatus for processing an OFDM MIMO signal in a system having at least two transmitters arranged to transmit an output signal pair that includes operating a series of transformations on a pair of input signals so that each stream of the output signal pair contains decodable information from both streams of the input signal pair.

Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

Abstract: A method of deriving a precoding matrix for a MIMO signal operates by maximising a function of channel capacity over values of precoding matrices so as to maximise the minimum channel capacity for the set of channel realisations. In this way, the least worst channel capacity may be achieved in broadcast arrangements in which the actual channel may be unknown.

Abstract: A coating is formed by chemical vapor deposition an electrically heated filament which is passed through an end plate into a deposition chamber and leaves the deposition chamber through a similar end plate. The filament slides through an entrance passage into the deposition chamber. The entrance passage is formed from misaligned portions which press the filament into direct electrical contact with their walls. A tube communicates with a chamber between the ends of the passage and acts as a sealing means to prevent gas escaping from the deposition chamber through the entrance passage. The end plate operates in exactly the same manner. As no mercury or a low-melting point eutectic alloy is used, no contaminants associated therewith are produced and the resultant coated filament is free of such contaminants.

Abstract: Disclosed are Serotonin 5-HT2B receptor inhibitors of the formula I. Also disclosed are methods of making and methods of using these compounds.

Abstract: A spline structure, in the form of an aeronautical brake drive bar, has wheel attachment points at its ends for engaging a wheel rim. Each wheel carries a regularly spaced series of these drive bars for engaging friction discs carried by the wheel hub. The main body of each brake drive bar is formed from titanium internally reinforced by composite blocks each comprising a bundle of silicon carbide fibers contained in a matrix that is diffusion bonded within the main body. Other spline structures can be formed in a similar manner.

Abstract: Derivatives of 6,7-dihydro-5H-imidazo[1,2-?]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract: Disclosed are Serotonin 5-HT2B receptor inhibitors of the formula I. Also disclosed are methods of making and methods of using these compounds.

Abstract: Derivatives of 6,7-dihydro-5H-imidazo[1,2-?]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract: The application relates to compounds of formula Ia and analogues thereof wherein R1 to R13 and X are as defined herein. The invention also relates to the use of the compounds of formula Ia as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.

Abstract: Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.

Abstract: A coating is formed by chemical vapour deposition an electrically heated filament which is passed through an end plate into a deposition chamber and leaves the deposition chamber through a similar end plate. The filament slides through an entrance passage into a first electrode chamber, around part of a wheel electrode into the deposition chamber. The passage of the filament around the wheel electrode provides adequate direct electrical contact. The end plate operates in exactly the same manner. As no mercury or a low-melting point eutectic alloy is used, no contaminants associated therewith are produced and the resultant coated filament is free of such contaminants.

Abstract: A coating is formed by chemical vapour deposition an electrically heated filament which is passed through an end plate into a deposition chamber and leaves the deposition chamber through a similar end plate. The filament slides through an entrance passage into the deposition chamber. The entrance passage is formed from misaligned portions which press the filament into direct electrical contact with their walls. A tube communicates with a chamber between the ends of the passage and acts as a sealing means to prevent gas escaping from the deposition chamber through the entrance passage. The end plate operates in exactly the same manner. As no mercury or a low-melting point eutectic alloy is used, no contaminants associated therewith are produced and the resultant coated filament is free of such contaminants.

Abstract: A spline structure, in the form of an aeronautical brake drive bar, has wheel attachment points at its ends for engaging a wheel rim. Each wheel carries a regularly spaced series of these drive bars for engaging friction discs carried by the wheel hub. The main body of each brake drive bar is formed from titanium internally reinforced by composite blocks each comprising a bundle of silicon carbide fibres contained in a matrix that is diffusion bonded within the main body. Other spline structures can be formed in a similar manner.

Abstract: An on-channel repeater has a receiving antenna for receiving an RF signal and a transmitting antenna for transmitting on the same frequency as the input signal. An amplification path between the antennas provides substantially linear processing and includes a combiner, a decorrelating delay and a power amplifier. A filter estimator receives a reference signal and the combiner output and generates a plurality of control coefficients which are applied to an adaptive filter which filters the reference signal accordingly and applies its output to the combiner. The reference signal is derived not from the output of the decorrelating delay but rather from the output antenna after the power amplifier. Where there is an adjacent transmitter generating potentially interfering signals, the transmitter output is coupled to the same transmitter antenna.