Abstract: This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.

Abstract: An antiperspirant aerosol composition comprising a three-component mixture of propellant, ethanol and a lipid mixture consisting of glycerol monolaurate and isostearyl alcohol at a ratio of from 25:75 to 45:55, wherein the propellant content of the three-component mixture is from 40 to 87.5%; the ethanol content of the three-component mixture is from 10 to 57.5% and the lipid content of the three-component mixture is from 2.5% up to a maximum equal to the sum of 4.805 and the ethanol content multiplied by 0.115.

Abstract: A method and system for adjusting properties of another system based on a risk score associated with an entity, using a framework comprising a server having a risk determinator, an API, and storage for storing a risk profile associated with the entity and a risk property associated the risk profile. The method is performed by the server, and comprises obtaining, from the storage, the risk profile associated with the entity, where the risk profile is generated by a risk determinator, and based on at least one risk property. The risk determinator generates the risk score associated with the entity based on the risk profile, and the server determines an adjustment to the properties of the system based on at least the risk score. The adjustment is output, through the API to the other system.

Abstract: A pharmacy container comprising a bottle and a closure. The bottle includes a body, a neck, stops on the neck defining a lug retention area. The body defines a storage chamber therein. The neck extends away from the body and defines an opening to the chamber of the body. The neck includes threads extending around an outside surface of the neck. The stops extend from a bottom of a first thread toward the body, the stops defining the lug retention area. The closure is secured over the opening and around the neck. The closure includes a lug configured to interface with the thread and engage with the lug retention area to retain the closure in place over the opening.

Abstract: The disclosure relates to a composition comprising adrenocorticotropic hormone (ACTH) or a synthetic ACTH analogue for use in a diagnostic test for adrenal insufficiency. A method to conduct said diagnostic test; a combined diagnostic and method of treatment; and kits comprising the components for said test are also disclosed.

Abstract: Embodiments of the present disclosure pertain to network based machine learning generated simulations. In one embodiment, the present disclosure includes a computer implemented method comprising sending first code comprising a programmable calculator from a server system to a client system across a network. A data request is sent to a database, the data request configured to retrieve data from the database comprising a plurality of fields and a target field. The retrieved data is processed using a machine learning algorithm to produce a weight for each field of the plurality of fields and a scoring data structure. The fields and the scoring data structure are sent to the client system across the network. A user selects values for the plurality of fields and the programmable calculator is configured based on the scoring data structure to generate a simulated value for the target field based on the user selected values.

Abstract: A system, method, and computer-readable medium to receive a request to render a visualization, the visualization to include a plurality of data point representations; determine an optimal number of data point representations to include on a first page of the visualization; render an active range of the plurality of data point representations on the first page of the visualization; apply at least one post-rendering optimization to the rendered first page; determine an estimation of an application of the at least one post-rendering optimization to a next page of the visualization; store the estimation of the application of at the least one post-rendering optimization to the next page of the visualization in a buffer memory; and display the rendered first page having the at least one post-rendering optimization applied thereto.

Abstract: A pharmacy container comprising a bottle and a closure is disclosed herein. The bottle includes a body, a neck, stops on the neck defining a lug retention area. The body defines a storage chamber therein. The neck extends away from the body and defines an opening to the chamber of the body. The neck includes threads extending around an outside surface of the neck. The stops extend from a bottom of a first thread toward the body, the stops defining the lug retention area. The closure is secured over the opening and around the neck. The closure includes a lug configured to interface with the thread and engage with the lug retention area to retain the closure in place over the opening. Other labels, bottles, associated combinations, and associated methods are also disclosed.

Abstract: A pharmacy container comprising a bottle and a closure is described herein. The bottle includes a body, a neck, stops on the neck defining a lug retention area. The body defines a storage chamber therein. The neck extends away from the body and defines an opening to the chamber of the body. The neck includes threads extending around an outside surface of the neck. The stops extend from a bottom of a first thread toward the body, the stops defining the lug retention area. The closure is secured over the opening and around the neck. The closure includes a lug configured to interface with the thread and engage with the lug retention area to retain the closure in place over the opening. Other labels, bottles, associated combinations, and associated methods are also described.

Abstract: Embodiments of the present disclosure pertain to network based machine learning generated simulations. In one embodiment, the present disclosure includes a computer implemented method comprising sending first code comprising a programmable calculator from a server system to a client system across a network. A data request is sent to a database, the data request configured to retrieve data from the database comprising a plurality of fields and a target field. The retrieved data is processed using a machine learning algorithm to produce a weight for each field of the plurality of fields and a scoring data structure. The fields and the scoring data structure are sent to the client system across the network. A user selects values for the plurality of fields and the programmable calculator is configured based on the scoring data structure to generate a simulated value for the target field based on the user selected values.

Abstract: Embodiments automatically create an axis break in a bar chart or waterfall chart to promote data visualization. For a bar chart with positive bars, a maximum axis break point is determined relative to a lowest datapoint (D1) in the selected bar(s). A minimum axis break point is found from a value (D2) outside selection which is between D1 and zero, and which is closest to D1. The inclusion of padding on either side of a break prevents the break from lying at zero or a bar end. A different procedure creates axis breaks in a waterfall chart. Certain embodiments store only bar selection metadata with a chart. The location of the axis break then is recalculated each time the chart is rendered (e.g., with updated data). Embodiments may retain axis break data for reference in various stages of a user interaction (e.g., filtering/expanding, drilling-down/up, etc.) with a rendered chart.

Abstract: A bottle that includes a body, a neck, stops on the neck defining a lug retention area. The body defines a storage chamber therein. The neck extends away from the body and defines an opening to the chamber of the body. The neck includes threads extending around an outside surface of the neck. The stops extend from a bottom of a first thread toward the body, the stops defining the lug retention area. The closure is secured over the opening and around the neck. The closure includes a lug configured to interface with the thread and engage with the lug retention area to retain the closure in place over the opening.

Abstract: A system, method, and computer-readable medium to receive a request to render a visualization, the visualization to include a plurality of data point representations; determine an optimal number of data point representations to include on a first page of the visualization; render an active range of the plurality of data point representations on the first page of the visualization; apply at least one post-rendering optimization to the rendered first page; determine an estimation of an application of the at least one post-rendering optimization to a next page of the visualization; store the estimation of the application of at the least one post-rendering optimization to the next page of the visualization in a buffer memory; and display the rendered first page having the at least one post-rendering optimization applied thereto.