Patents by Inventor Neil Pravin Shah

Neil Pravin Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
    Publication number: 20190144946
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 16, 2019
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Patent number: 9994910
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bu-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: June 12, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
    Publication number: 20160130655
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bu-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 12, 2016
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Patent number: 9085644
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: July 21, 2015
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571
    Patent number: 9056924
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: June 16, 2015
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • FLT3 MUTATIONS ASSOCIATED WITH DRUG RESISTANCE IN AML PATIENTS HAVING ACTIVATING MUTATIONS IN FLT3
    Publication number: 20140242590
    Abstract: The invention provides methods and compositions for identifying acute myeloid leukemia (AML) patients that have an increased likelihood of a relapse following treatment with AC 220.
    Type: Application
    Filed: October 26, 2012
    Publication date: August 28, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Neil Pravin Shah, Catherine Choy Smith
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Patent number: 8697348
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: April 15, 2014
    Assignee: The Regent of the University of California
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to ST1-571
    Patent number: 8586291
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: November 19, 2013
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
    Publication number: 20120282622
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 8, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
    Publication number: 20120021425
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: September 29, 2011
    Publication date: January 26, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
    Publication number: 20100248241
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: March 24, 2010
    Publication date: September 30, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the BCR-ABL tyrosine kinase associated with resistance to ST1-571
    Publication number: 20100055687
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: March 11, 2009
    Publication date: March 4, 2010
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • T315A AND F317I MUTATIONS OF BCR-ABL KINASE DOMAIN
    Publication number: 20100029676
    Abstract: The present invention relates to mutant BCR-ABL kinase proteins, and to diagnostic and therapeutic methods and compositions useful in the management of disorders, for example cancers, involving cells that express such mutant BCR-ABL kinase proteins.
    Type: Application
    Filed: November 3, 2006
    Publication date: February 4, 2010
    Inventors: Charles L. Sawyers, Michael Burgess, Neil Pravin Shah, Francis Y. Lee, John S. Tokarski, Herbert E. Klei
  • Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571
    Publication number: 20090155787
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: April 4, 2008
    Publication date: June 18, 2009
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Patent number: 7521175
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: April 21, 2009
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Publication number: 20030158105
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: June 14, 2002
    Publication date: August 21, 2003
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll