Patents by Inventor Neil R. Ackerman

Neil R. Ackerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of organ transplantation rejection
    Patent number: 5204329
    Abstract: 4-Quinoline-carboxylic acid derivatives, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinoline carboxylic acid, in combination with other immunosuppressive agents are useful for the treatment and/or prevention of transplantation rejection, graft vs. host disease, autoimmune diseases, and chronic inflammatory disease.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: April 20, 1993
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Neil R. Ackerman, Bruce D. Jaffee
  • Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
    Patent number: 5102883
    Abstract: The pyrimidine biosynthesis inhibitors dichloroallyl lawsone, N-(phosphonoacetyl)-L-aspartic acid (PALA), pyrazofurin, and derivatives thereof, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing these compounds are useful for the treatment of autoimmune diseases, chronic inflammatory diseases, and of organ transplantation rejections.
    Type: Grant
    Filed: October 31, 1989
    Date of Patent: April 7, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Neil R. Ackerman, Bruce D. Jaffee
  • 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents
    Patent number: 5084462
    Abstract: 4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.
    Type: Grant
    Filed: June 28, 1990
    Date of Patent: January 28, 1992
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Neil R. Ackerman, Bruce D. Jaffee, Scott E. Loveless, Russell H. Neubauer
  • 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents
    Patent number: 4968701
    Abstract: 4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: November 6, 1990
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Neil R. Ackerman, Richard R. Harris, Scott E. Loveless, Russell H. Neubauer
  • 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases
    Patent number: 4861783
    Abstract: Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful for the treatment of skin and muco-epithelial diseases.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: August 29, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Neil R. Ackerman, Richard R. Harris, Scott E. Loveless, Russel H. Neubauer
  • Method of preventing, reducing or inhibiting inflammation
    Patent number: 4357322
    Abstract: Inflammation is prevented, reduced or inhibited by administering muramyl and desmethylmuramyl dipeptides of the general formula: ##STR1## wherein each of R.sup.1 through R.sup.5 can independently be hydrogen or a variety of substituted or unsubstituted acyl, alkyl, aryl, or arylalkyl substituents. Pharmaceutical compositions containing such compounds useful for reducing inflammation are described.
    Type: Grant
    Filed: July 29, 1980
    Date of Patent: November 2, 1982
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Wendell H. Rooks, II, Neil R. Ackerman, Albert J. Tomolonis