Abstract: The invention described herein provides for a portable autonomic nerve system stimulation device that may operate as an “open-loop” or “closed-loop” stimulation system and includes in some embodiments a paired therapy for a disease or condition. Embodiments of the inventive device include at least one stimulation circuit for the generation and delivery of a stimulation, at least one biological signal monitoring apparatus for monitoring a biological state of a user wearing the device, at least one controller in electrical communication with the stimulation circuit and at least one power supply for providing power to the controller and stimulation circuit. Aspects of the invention provides for a portable autonomic nerve system stimulation device which may be worn in the ear, or about the head, of a subject, patient or user.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag haying an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: System and method for ingestion event detection and monitoring are disclosed. The system comprises: an ingestible microsensor configured to generate a signal representing an ingestion event upon ingestion and contact with stomach fluid of a patient; and a reader device positioned external to the patient and configured to detect the signal representing the ingestion event with at least 95% accuracy.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: System and method for ingestion event detection and monitoring are disclosed. The system comprises: an ingestible microsensor configured to generate a signal representing an ingestion event upon ingestion and contact with stomach fluid of a patient; and a reader device positioned external to the patient and configured to detect the signal representing the ingestion event with at least 95% accuracy.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: An aspect of the invention is a liquid sensor having a galvanically energizable power source capable of activating a remotely detectable signal in response to liquid. In a preferred embodiment, a liquid sensor includes a plurality of electrodes, a circuit, and a transmitter thereon. The electrodes are coupled to generate electrical power when in contact with liquid. The circuit is electrically connected to the electrodes so as to be activated by the electrical power, detect an electrical parameter of the electrical power, and generate a plurality of data packets indicating a degree of wetness corresponding to the detected electrical parameter. The transmitter is electrically coupled to the circuit to receive the plurality of data packets and transmit representations of the plurality of data packets as electromagnetic signals. Other aspects include a liquid absorbent wetness sensor and a computer-based wetness monitoring system, and method of detecting liquid.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: System and method for ingestion event detection and monitoring are disclosed. The system comprises: an ingestible microsensor configured to generate a signal representing an ingestion event upon ingestion and contact with stomach fluid of a patient; and a reader device positioned external to the patient and configured to detect the signal representing the ingestion event with at least 95% accuracy.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag having an antenna and a receiver/transmitter positioned with a medication capsule, and a reader positioned externally for detecting the presence and location of the tag in the patient.

Abstract: The present invention describes a method and apparatus for detecting and quantifying intrinsic positive end-expiratory pressure (PEEPi) of a respiratory patient breathing with the assistance of a ventilator. A processing device receives respiratory airway data from one or more sensors adapted to non-invasively monitor a respiratory patient, calculates from the respiratory airway data two or more parameters that are indicative of or quantify intrinsic positive end-expiratory pressure of the patient, and generates an indication intrinsic positive end-expiratory pressure (PEEPi).

Abstract: Provided according to embodiments of the invention are methods for monitoring the application of positive end expiratory pressure (PEEP) to an individual. Such methods include isolating a pulsatile arterial component (PAC) signal and a venous impedance component (VIC) signal of a PPG signal obtained from a central source site of the individual; monitoring the PAC signal, the VIC signal, or both, over time; and adjusting the level of PEEP based on the PAC signal, the VIC signal, or both.

Abstract: A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Abstract: Provided according to embodiments of the invention are methods for monitoring the application of positive end expiratory pressure (PEEP) to an individual. Such methods include isolating a pulsatile arterial component (PAC) signal and a venous impedance component (VIC) signal of a PPG signal obtained from a central source site of the individual; monitoring the PAC signal, the VIC signal, or both, over time; and adjusting the level of PEEP based on the PAC signal, the VIC signal, or both.

Abstract: Disclosed herein are apparatuses and methods to monitor respiration and abnormal respiration events utilizing plethysmography. The apparatuses and methods provide an alternative to conventional respiration monitoring methods while enabling accurate yet minimally interruptive and invasive monitoring of respiration. The methods and apparatuses may be employed in the context of sleep studies to determine respiratory related sleep disorders.

Abstract: The present invention describes a method and apparatus for detecting and quantifying intrinsic positive end-expiratory pressure (PEEPi) of a respiratory patient breathing with the assistance of a ventilator. A processing device receives respiratory airway data from one or more sensors adapted to non-invasively monitor a respiratory patient, calculates from the respiratory airway data two or more parameters that are indicative of or quantify intrinsic positive end-expiratory pressure of the patient, and generates an indication intrinsic positive end-expiratory pressure (PEEPi).

Abstract: Disclosed herein are methods and devices of obtaining plethysmograph readings and utilizing plethysomography to identify when pilots are about to experience GLOC. Furthermore, in other embodiments, the invention pertains to methods and devices designed to warn a pilot that he/she is about to enter GLOC and/or automatically averting catastrophic damage or injuries by directing a plane being piloted to take predetermined corrective actions. Specifically disclosed is a system embodiment for assisting in the prevention of gravity induced loss of consciousness.

Abstract: A method of creating a noninvasive predictor of both physiologic and imposed patient effort of breathing from airway pressure and flow sensors attached to the patient using an adaptive mathematical model. The patient effort is commonly measured via work of breathing, power of breathing, or pressure-time product of esophageal pressure and is important for properly adjusting ventilatory support for spontaneously breathing patients. The method of calculating this noninvasive predictor is based on linear or non-linear calculations using multiple parameters derived from the above-mentioned sensors.

Abstract: Disclosed herein are methods and devices for delivering gas to a subject and obtaining plethysmograph readings from a subject. Specifically disclosed herein are masks and helmets which comprise one or more pulse oximeter probes associated therewith. The masks and helmets may be used in particular contexts, including, but not limited to, emergency responder personnel, pilots or subjects of medical attention.