Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.

Abstract: A container (20) includes a base surface (25) having walls (21, 22, 23 and 24) extending therefrom which together form an opening for the container (20). A door (26) is attached to one wall (24) by a hinge (27) to close the opening. A thermoelectric power module (43) is removably mounted in a recess (66) formed in one wall (21) and selectively heats and cools the interior of the container (20). The container (20) may thus be selectively positioned on either the base surface (25) or on one of two walls (22, 23). A power cord (57) is attached to the module (43) and carries a plug (58) so that the module (43) may be connected to a source of electric power. A switch (61) on the plug (58) directs the module (43) to selectively cool or heat the interior of the container (20). The cord (57) may be routed in channels (70, 72, 73, 74) formed in the base surface (25) from module (43) to any of the walls (22, 23, 24) and may be stored in a recess (77) formed in the base surface (25) and wall (24).