Patents by Inventor Neil Russell Foster
Neil Russell Foster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140086994Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.Type: ApplicationFiled: December 4, 2013Publication date: March 27, 2014Applicant: MAP Pharmaceuticals, Inc.Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani
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Patent number: 8609611Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.Type: GrantFiled: December 14, 2011Date of Patent: December 17, 2013Assignee: MAP Pharmaceuticals, Inc.Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani
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Patent number: 8475845Abstract: A method of co-formulating two or more pharmaceutically active compounds into a particulate product including contacting a dense, supercritical or near-critical fluid With a suspension of a first active compound in a medium that is miscible with the dense fluid and a solution of a second active compound in a solvent that is miscible with the dense fluid. The product may be the first active agent coated with the second active agent. The method may use coaxial nozzles for the fluid, media or solvents. The method may be applied to production of dry powders for inhalation including beta-agonists and corticosteroids. Apparatus for use in the method comprising means for streams of solvents, media and dense fluids to enter a precipitation chamber at substantially the same point and means for collection of particles under gravity in one or more collection chambers.Type: GrantFiled: July 14, 2006Date of Patent: July 2, 2013Assignee: MAP Pharmaceuticals, Inc.Inventors: Linda Sze Tu, Hubert Leonardus Regtop, Neil Russell Foster, Pascal Hickey
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Patent number: 8389013Abstract: A process for producing particles of a substance is described wherein a solution of the substance in a solvent is delivered in at least one shot into a supercritical fluid. The supercritical fluid is a non-solvent for the substance and is miscible with the solvent. Particles of the substance distributed in a mixture of the solvent and the supercritical fluid are formed.Type: GrantFiled: October 5, 2007Date of Patent: March 5, 2013Assignee: Newsouth Innovations PTY LimitedInventors: Neil Russell Foster, Roderick Peng Tze Sih
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Publication number: 20120090604Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.Type: ApplicationFiled: December 14, 2011Publication date: April 19, 2012Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani
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Patent number: 8147730Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.Type: GrantFiled: December 23, 2009Date of Patent: April 3, 2012Assignee: MAP Pharmaceuticals, Inc.Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani
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Publication number: 20110104291Abstract: The invention provides a method for manipulating or formulating a solid substance which melts under pressure of a gas without degrading at a temperature lower than the melting point of the substance at atmospheric pressure including: applying to the substance a liquefied gas or dense gas to melt the substance without degrading the substance; then contacting the molten substance with a carrier fluid, which is at substantially the same pressure as the liquefied gas or dense gas, to form a solution or mixture of at least a part of the molten substance and the carrier fluid; and passing the solution or mixture into a vessel of lower pressure than the pressure of the liquefied gas or dense gas and carrier fluid to form particles of the substance; and particles formed by the method.Type: ApplicationFiled: December 21, 2010Publication date: May 5, 2011Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani, Andrian Tandya
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Patent number: 7862751Abstract: The invention provides a method for manipulating or formulating a solid substance which melts under pressure of a gas without degrading at a temperature lower than the melting point of the substance at atmospheric pressure including: applying to the substance a liquefied gas or dense gas to melt the substance without degrading the substance; then contacting the molten substance with a carrier fluid, which is at substantially the same pressure as the liquefied gas or dense gas, to form a solution or mixture of at least a part of the molten substance and the carrier fluid; and passing the solution or mixture into a vessel of lower pressure than the pressure of the liquefied gas or dense gas and carrier fluid to form particles of the substance; and particles formed by the method.Type: GrantFiled: April 15, 2003Date of Patent: January 4, 2011Assignee: MAP Pharmaceuticals, Inc.Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani, Andrian Tandya
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Publication number: 20100247655Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.Type: ApplicationFiled: December 23, 2009Publication date: September 30, 2010Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani
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Publication number: 20100144670Abstract: A process for producing particles of a substance is described wherein a solution of the substance in a solvent is delivered in at least one shot into a supercritical fluid. The supercritical fluid is a non-solvent for the substance and is miscible with the solvent. Particles of the substance distributed in a mixture of the solvent and the supercritical fluid are formed.Type: ApplicationFiled: October 5, 2007Publication date: June 10, 2010Inventors: Neil Russell Foster, Roderick Peng Tze Sih
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Patent number: 7641823Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.Type: GrantFiled: December 6, 2002Date of Patent: January 5, 2010Assignee: MAP Pharmaceuticals, Inc.Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani
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Publication number: 20090004282Abstract: A method of co-formulating two or more pharmaceutically active compounds into a particulate product including contacting a dense, supercritical or near-critical fluid With a suspension of a first active compound in a medium that is miscible with the dense fluid and a solution of a second active compound in a solvent that is miscible with the dense fluid. The product may be the first active agent coated with the second active agent. The method may use coaxial nozzles for the fluid, media or solvents. The method may be applied to production of dry powders for inhalation including beta-agonists and corticosteroids. Apparatus for use in the method comprising means for streams of solvents, media and dense fluids to enter a precipitation chamber at substantially the same point and means for collection of particles under gravity in one or more collection chambers.Type: ApplicationFiled: July 14, 2006Publication date: January 1, 2009Inventors: Linda Sze Tu, Hubert Leonardus Regtop, Neil Russell Foster, Pascal Hickey
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Publication number: 20060151900Abstract: The invention provides a method for manipulating or formulating a solid substance which melts under pressure of a gas without degrading at a temperature lower than the melting point of the substance at atmospheric pressure including: applying to the substance a liquefied gas or dense gas to melt the substance without degrading the substance; then contacting the molten substance with a carrier fluid, which is at substantially the same pressure as the liquefied gas or dense gas, to form a solution or mixture of at least a part of the molten substance and the carrier fluid; and passing the solution or mixture into a vessel of lower pressure than the pressure of the liquefied gas or dense gas and carrier fluid to form particles of the substance; and particles formed by the method.Type: ApplicationFiled: April 15, 2003Publication date: July 13, 2006Inventors: Neil Russell Foster, Hubert Regtop, Fariba Dehghani, Andrian Tandya
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Publication number: 20030013634Abstract: The invention provides a method for forming fine particles of a substance, the method including contacting a non-gaseous fluid containing the substance with a dense gas to expand the fluid, the dense gas including (a) an anti-solvent and (b) a modifying agent which modifies the polarity of the anti-solvent, and particles formed by the method.Type: ApplicationFiled: December 7, 2001Publication date: January 16, 2003Inventors: Neil Russell Foster, Hubert Leonardus Regtop, Fariba Dehghani, Rana Taysir Bastami, Hak-Kim Chan