Patents by Inventor Neil S Cutshall

Neil S Cutshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20250197349
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20250129020
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Application
    Filed: September 18, 2024
    Publication date: April 24, 2025
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20250122225
    Abstract: The disclosure provides synthetic compositions useful as inhibitors of mannan-binding lectin-associated serine protease-2 (MASP-2), including inhibitors that selectively inhibit MASP-2 over thrombin, as well as methods for the manufacture and use thereof.
    Type: Application
    Filed: October 4, 2024
    Publication date: April 17, 2025
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Melinda Renee Davis, Jennifer Lynn Gage, Sara Rebecca Goldstein, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Sudheer Babu Vaddela, Connor Weidle
  • MASP-2 inhibitors and methods of use
    Patent number: 12195427
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: January 14, 2025
    Assignee: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20250011323
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: July 18, 2024
    Publication date: January 9, 2025
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung, Jeremiah H. Nguyen, Melinda Davis, Robert Huerta Lemus, Santosh Kumar Keshipeddy, Sara Rebecca Goldstein
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20240391917
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: July 18, 2024
    Publication date: November 28, 2024
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung, Jeremiah H. Nguyen, Melinda Davis, Robert Huerta, Santosh Kumar Keshipeddy, Sara Rebecca Goldstein
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20240351980
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: May 31, 2024
    Publication date: October 24, 2024
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung
  • MASP-2 inhibitors and methods of use
    Patent number: 12110288
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: October 8, 2024
    Assignee: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Do Yeon Kwon, Thomas L Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung, Jeremiah H. Nguyen, Melinda Davis, Robert Huerta Lemus, Santosh Kumar Keshipeddy, Sara Rebecca Goldstein
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20240317682
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: May 31, 2024
    Publication date: September 26, 2024
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung
  • Methods and Compositions for Treating Cancer
    Publication number: 20240307537
    Abstract: This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).
    Type: Application
    Filed: August 17, 2023
    Publication date: September 19, 2024
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Marc A. Gavin, Alexander Gragerov, Thomas L. Little, Rene Onrust
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20240228499
    Abstract: The disclosure provides synthetic compositions useful as inhibitors of mannan-binding lectin-associated serine protease-2 (MASP-2), including compositions that selectively inhibit MASP-2 over thrombin, as well as methods for the manufacture and use thereof.
    Type: Application
    Filed: November 29, 2023
    Publication date: July 11, 2024
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert von Specht, Jennifer Tsoung, Sudheer Babu Vaddela, Connor Weidle
  • MASP-2 inhibitors and methods of use
    Patent number: 12030853
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: July 9, 2024
    Assignee: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Do Yeon Kwon, Thomas L. Little, Markus Metz, Peter Kurt Nollert Von Specht, Jennifer Tsoung
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20240092788
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: September 6, 2023
    Publication date: March 21, 2024
    Applicant: Omeros Corporation
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert Von Specht, Loren Michael Price, Jennifer Tsoung, Sudheer Babu Vaddela
  • MASP-2 inhibitors and methods of use
    Patent number: 11807641
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: November 7, 2023
    Assignee: Omeros Corporation
    Inventors: Michael Cicirelli, Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Loren Michael Price, Jennifer Tsoung, Sudheer Babu Vaddela
  • Inhibitors of GPR174 and Uses Thereof
    Publication number: 20230321083
    Abstract: GPR174 is an orphan receptor that has been implicated in cancer, nervous system diseases and disorders and neuroregeneration. We have identified inhibitors of GPR174 and have identified the G-protein signaling pathways that GPR174 modulates. Based on this discovery, the present invention features methods for inhibiting GPR174 activity and thereby stimulating an immune response in a subject in need thereof, particularly in the use of treatment of non-malignant neoplasms, malignant neoplasms (i.e., cancer), nervous system diseases and disorders and neuroregeneration, as well as related compositions.
    Type: Application
    Filed: October 11, 2022
    Publication date: October 12, 2023
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Alexander Gragerov, Thomas L. Little, Rene Onrust
  • MASP-2 inhibitors and methods of use
    Patent number: 11661418
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 30, 2023
    Assignee: OMEROS CORPORATION
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Thomas L. Little, Markus Metz, Peter Kurt Nollert Von Specht, Loren Michael Price, Jennifer Tsoung
  • MASP-2 INHIBITORS AND METHODS OF USE
    Publication number: 20230145071
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Application
    Filed: November 30, 2022
    Publication date: May 11, 2023
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • MASP-2 inhibitors and methods of use
    Patent number: 11584714
    Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: February 21, 2023
    Assignee: OMEROS CORPORATION
    Inventors: Neil S. Cutshall, Jennifer Lynn Gage, Franz A. Gruswitz, Juhienah Khalaf, Thomas L. Little, Markus Metz, Jeremiah H. Nguyen, Peter Kurt Nollert von Specht, Jennifer Tsoung, Michael Cicirelli, Sara Rebecca Goldstein, Santosh Kumar Keshipeddy, Do Yeon Kwon, Robert Huerta Lemus, Sudheer Babu Vaddela
  • Methods and Compositions for Treating Cancer
    Publication number: 20200345725
    Abstract: This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).
    Type: Application
    Filed: January 10, 2020
    Publication date: November 5, 2020
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Marc A. Gavin, Alexander Gragerov, Thomas L. Little, Rene Onrust
  • Inhibitors of GPR174 and Uses Thereof
    Publication number: 20200276190
    Abstract: GPR174 is an orphan receptor that has been implicated in cancer, nervous system diseases and disorders and neuroregeneration. We have identified inhibitors of GPR174 and have identified the G-protein signaling pathways that GPR174 modulates. Based on this discovery, the present invention features methods for inhibiting GPR174 activity and thereby stimulating an immune response in a subject in need thereof, particularly in the use of treatment of non-malignant neoplasms, malignant neoplasms (i.e., cancer), nervous system diseases and disorders and neuroregeneration, as well as related compositions.
    Type: Application
    Filed: November 13, 2019
    Publication date: September 3, 2020
    Inventors: Michael Cicirelli, Neil S. Cutshall, Gregory A. Demopulos, George A. Gaitanaris, Alexander Gragerov, Thomas L. Little, Rene Onrust