Patents by Inventor Neil Sheppard

Neil Sheppard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTOR (CAR)-T SIGNALING OPTIMIZATION FOR TUNING ANTIGEN ACTIVATION THRESHOLD
    Publication number: 20240325534
    Abstract: The present invention provides compositions and methods comprising chimeric antigen receptors (CARs) wherein the ‘Signal 1’ has been optimized, for example wherein the CAR comprises an intracellular domain comprising a truncated version of CD3?, a FcR? or portion thereof, or a hybrid of CD3? and CD3?. Compositions and methods of treatment are also provided.
    Type: Application
    Filed: July 19, 2022
    Publication date: October 3, 2024
    Inventors: Neil Sheppard, Yi Wen
  • ADJUVANT
    Publication number: 20090297551
    Abstract: This invention relates to a novel adjuvant comprising a transfection reagent, and to uses of this adjuvant. In particular, the adjuvant may be used in compositions for eliciting an immune response and in vaccines.
    Type: Application
    Filed: March 19, 2007
    Publication date: December 3, 2009
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Quentin Sattentau, Neil Sheppard